Dynamic clonal equilibrium and predetermined cancer risk in Barrett’s oesophagus

Barrett’s oesophagus is thought to be a precursor lesion for oesophageal cancer, and predicting the benign lesions that progress to cancer is clinically important. Here, the authors use FISH to study the clonal evolution of Barrett’s oesophagus and show that genetic diversity and somatic mutations a...

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Autores principales:	Pierre Martinez, Margriet R. Timmer, Chiu T. Lau, Silvia Calpe, Maria del Carmen Sancho-Serra, Danielle Straub, Ann-Marie Baker, Sybren L. Meijer, Fiebo J. W. ten Kate, Rosalie C. Mallant-Hent, Anton H. J. Naber, Arnoud H. A. M. van Oijen, Lubbertus C. Baak, Pieter Scholten, Clarisse J. M. Böhmer, Paul Fockens, Jacques J. G. H. M. Bergman, Carlo C. Maley, Trevor A. Graham, Kausilia K Krishnadath
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/30abe593d39a4da4b5f584456b184821
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spelling	oai:doaj.org-article:30abe593d39a4da4b5f584456b1848212021-12-02T14:38:54ZDynamic clonal equilibrium and predetermined cancer risk in Barrett’s oesophagus10.1038/ncomms121582041-1723https://doaj.org/article/30abe593d39a4da4b5f584456b1848212016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12158https://doaj.org/toc/2041-1723Barrett’s oesophagus is thought to be a precursor lesion for oesophageal cancer, and predicting the benign lesions that progress to cancer is clinically important. Here, the authors use FISH to study the clonal evolution of Barrett’s oesophagus and show that genetic diversity and somatic mutations are present early in the benign disease.Pierre MartinezMargriet R. TimmerChiu T. LauSilvia CalpeMaria del Carmen Sancho-SerraDanielle StraubAnn-Marie BakerSybren L. MeijerFiebo J. W. ten KateRosalie C. Mallant-HentAnton H. J. NaberArnoud H. A. M. van OijenLubbertus C. BaakPieter ScholtenClarisse J. M. BöhmerPaul FockensJacques J. G. H. M. BergmanCarlo C. MaleyTrevor A. GrahamKausilia K KrishnadathNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pierre Martinez Margriet R. Timmer Chiu T. Lau Silvia Calpe Maria del Carmen Sancho-Serra Danielle Straub Ann-Marie Baker Sybren L. Meijer Fiebo J. W. ten Kate Rosalie C. Mallant-Hent Anton H. J. Naber Arnoud H. A. M. van Oijen Lubbertus C. Baak Pieter Scholten Clarisse J. M. Böhmer Paul Fockens Jacques J. G. H. M. Bergman Carlo C. Maley Trevor A. Graham Kausilia K Krishnadath Dynamic clonal equilibrium and predetermined cancer risk in Barrett’s oesophagus
description	Barrett’s oesophagus is thought to be a precursor lesion for oesophageal cancer, and predicting the benign lesions that progress to cancer is clinically important. Here, the authors use FISH to study the clonal evolution of Barrett’s oesophagus and show that genetic diversity and somatic mutations are present early in the benign disease.
format	article
author	Pierre Martinez Margriet R. Timmer Chiu T. Lau Silvia Calpe Maria del Carmen Sancho-Serra Danielle Straub Ann-Marie Baker Sybren L. Meijer Fiebo J. W. ten Kate Rosalie C. Mallant-Hent Anton H. J. Naber Arnoud H. A. M. van Oijen Lubbertus C. Baak Pieter Scholten Clarisse J. M. Böhmer Paul Fockens Jacques J. G. H. M. Bergman Carlo C. Maley Trevor A. Graham Kausilia K Krishnadath
author_facet	Pierre Martinez Margriet R. Timmer Chiu T. Lau Silvia Calpe Maria del Carmen Sancho-Serra Danielle Straub Ann-Marie Baker Sybren L. Meijer Fiebo J. W. ten Kate Rosalie C. Mallant-Hent Anton H. J. Naber Arnoud H. A. M. van Oijen Lubbertus C. Baak Pieter Scholten Clarisse J. M. Böhmer Paul Fockens Jacques J. G. H. M. Bergman Carlo C. Maley Trevor A. Graham Kausilia K Krishnadath
author_sort	Pierre Martinez
title	Dynamic clonal equilibrium and predetermined cancer risk in Barrett’s oesophagus
title_short	Dynamic clonal equilibrium and predetermined cancer risk in Barrett’s oesophagus
title_full	Dynamic clonal equilibrium and predetermined cancer risk in Barrett’s oesophagus
title_fullStr	Dynamic clonal equilibrium and predetermined cancer risk in Barrett’s oesophagus
title_full_unstemmed	Dynamic clonal equilibrium and predetermined cancer risk in Barrett’s oesophagus
title_sort	dynamic clonal equilibrium and predetermined cancer risk in barrett’s oesophagus
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/30abe593d39a4da4b5f584456b184821
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Dynamic clonal equilibrium and predetermined cancer risk in Barrett’s oesophagus

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