Smartphone-integrated colorimetric sensor array-based reader system and fluorometric detection of dopamine in male and female geriatric plasma by bluish-green fluorescent carbon quantum dots

A simple, cost-effective system was developed for dopamine (DA) detection using green synthesized 1–6 nm honey-based carbon quantum dots (H-CQDs) exhibiting bluish green fluorescence. The H-CQDs exhibited emission at 445 nm, with a quantum yield of ∼44%. The H-CQDs were used as a probe for electro...

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Autores principales:	Gayathri Chellasamy, Seshadri Reddy Ankireddy, Kook-Nyung Lee, Saravanan Govindaraju, Kyusik Yun
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Bluish green carbon quantum dots Naked eye detection Smartphone platform Fluorometric sensing Dopamine Geriatric plasma Medicine (General) R5-920 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/30ac5afb80e54b6dbf46744977f0bb28
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spelling	oai:doaj.org-article:30ac5afb80e54b6dbf46744977f0bb282021-11-28T04:37:32ZSmartphone-integrated colorimetric sensor array-based reader system and fluorometric detection of dopamine in male and female geriatric plasma by bluish-green fluorescent carbon quantum dots2590-006410.1016/j.mtbio.2021.100168https://doaj.org/article/30ac5afb80e54b6dbf46744977f0bb282021-09-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2590006421000764https://doaj.org/toc/2590-0064A simple, cost-effective system was developed for dopamine (DA) detection using green synthesized 1–6 nm honey-based carbon quantum dots (H-CQDs) exhibiting bluish green fluorescence. The H-CQDs exhibited emission at 445 nm, with a quantum yield of ∼44%. The H-CQDs were used as a probe for electron transfer based DA detection and changes in H-CQD color in the presence of DA. The H-CQDs were formed with polar functional groups and were highly soluble in aqueous media. In the fluorometric mode, the proposed system demonstrated high specificity toward DA and effective limit of detection (LOD) values of 6, 8.5, and 8 nM in deionized (DI) water, male geriatric plasma, and female geriatric plasma, respectively, in the linear range 100 nM–1000 μM. In the colorimetric mode, the color changed within 5 min, and the LOD was 163 μM. A colorimetric sensor array system was used to precisely detect DA with a smartphone-integrated platform using an in house built imaging application and an analyzer app. Additionally, no additives were required, and the H-CQDs were not functionalized. More importantly, the H-CQDs were morphologically and analytically characterized before and after DA detection. Because the sensor array-based system allows high specificity DA detection in both DI water and geriatric plasma, it will play an important role in biomedical applications.Gayathri ChellasamySeshadri Reddy AnkireddyKook-Nyung LeeSaravanan GovindarajuKyusik YunElsevierarticleBluish green carbon quantum dotsNaked eye detectionSmartphone platformFluorometric sensingDopamineGeriatric plasmaMedicine (General)R5-920Biology (General)QH301-705.5ENMaterials Today Bio, Vol 12, Iss , Pp 100168- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bluish green carbon quantum dots Naked eye detection Smartphone platform Fluorometric sensing Dopamine Geriatric plasma Medicine (General) R5-920 Biology (General) QH301-705.5
spellingShingle	Bluish green carbon quantum dots Naked eye detection Smartphone platform Fluorometric sensing Dopamine Geriatric plasma Medicine (General) R5-920 Biology (General) QH301-705.5 Gayathri Chellasamy Seshadri Reddy Ankireddy Kook-Nyung Lee Saravanan Govindaraju Kyusik Yun Smartphone-integrated colorimetric sensor array-based reader system and fluorometric detection of dopamine in male and female geriatric plasma by bluish-green fluorescent carbon quantum dots
description	A simple, cost-effective system was developed for dopamine (DA) detection using green synthesized 1–6 nm honey-based carbon quantum dots (H-CQDs) exhibiting bluish green fluorescence. The H-CQDs exhibited emission at 445 nm, with a quantum yield of ∼44%. The H-CQDs were used as a probe for electron transfer based DA detection and changes in H-CQD color in the presence of DA. The H-CQDs were formed with polar functional groups and were highly soluble in aqueous media. In the fluorometric mode, the proposed system demonstrated high specificity toward DA and effective limit of detection (LOD) values of 6, 8.5, and 8 nM in deionized (DI) water, male geriatric plasma, and female geriatric plasma, respectively, in the linear range 100 nM–1000 μM. In the colorimetric mode, the color changed within 5 min, and the LOD was 163 μM. A colorimetric sensor array system was used to precisely detect DA with a smartphone-integrated platform using an in house built imaging application and an analyzer app. Additionally, no additives were required, and the H-CQDs were not functionalized. More importantly, the H-CQDs were morphologically and analytically characterized before and after DA detection. Because the sensor array-based system allows high specificity DA detection in both DI water and geriatric plasma, it will play an important role in biomedical applications.
format	article
author	Gayathri Chellasamy Seshadri Reddy Ankireddy Kook-Nyung Lee Saravanan Govindaraju Kyusik Yun
author_facet	Gayathri Chellasamy Seshadri Reddy Ankireddy Kook-Nyung Lee Saravanan Govindaraju Kyusik Yun
author_sort	Gayathri Chellasamy
title	Smartphone-integrated colorimetric sensor array-based reader system and fluorometric detection of dopamine in male and female geriatric plasma by bluish-green fluorescent carbon quantum dots
title_short	Smartphone-integrated colorimetric sensor array-based reader system and fluorometric detection of dopamine in male and female geriatric plasma by bluish-green fluorescent carbon quantum dots
title_full	Smartphone-integrated colorimetric sensor array-based reader system and fluorometric detection of dopamine in male and female geriatric plasma by bluish-green fluorescent carbon quantum dots
title_fullStr	Smartphone-integrated colorimetric sensor array-based reader system and fluorometric detection of dopamine in male and female geriatric plasma by bluish-green fluorescent carbon quantum dots
title_full_unstemmed	Smartphone-integrated colorimetric sensor array-based reader system and fluorometric detection of dopamine in male and female geriatric plasma by bluish-green fluorescent carbon quantum dots
title_sort	smartphone-integrated colorimetric sensor array-based reader system and fluorometric detection of dopamine in male and female geriatric plasma by bluish-green fluorescent carbon quantum dots
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/30ac5afb80e54b6dbf46744977f0bb28
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Smartphone-integrated colorimetric sensor array-based reader system and fluorometric detection of dopamine in male and female geriatric plasma by bluish-green fluorescent carbon quantum dots

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