Nascent chains can form co-translational folding intermediates that promote post-translational folding outcomes in a disease-causing protein

Nascent chains can form co-translational folding intermediates that promote post-translational folding outcomes in a disease-causing protein

Alpha-1-antitrypsin (AAT) deficiency results from misfolding-prone AAT variants. Here the authors show that AAT forms co-translational folding intermediates on the ribosome that persist upon release and determine its folding fate. They show too that the ribosome can also modulate misfolding-prone AA...

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Autores principales: Elena Plessa, Lien P. Chu, Sammy H. S. Chan, Oliver L. Thomas, Anaïs M. E. Cassaignau, Christopher A. Waudby, John Christodoulou, Lisa D. Cabrita
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
Q
Acceso en línea:https://doaj.org/article/30b1313e15054f30a9de5b5032f07b04
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