Relationship between nutritional status and frailty in hospitalized older patients

Xiufang Hong,1,2 Jing Yan,1 Liyu Xu,1 Shanshan Shen,1 Xingkun Zeng,1 Lingyan Chen1 1Department of Geriatrics, Zhejiang Hospital, Hangzhou 310013, People’s Republic of China; 2The Second School of Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, People’s Republic o...

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Autores principales:	Hong X, Yan J, Xu L, Shen S, Zeng X, Chen L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	frailty nutrition malnutrition frailty phenotype Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/30b56e8fc7e5414799ad7ce9f7bbc989
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spelling	oai:doaj.org-article:30b56e8fc7e5414799ad7ce9f7bbc9892021-12-02T02:36:58ZRelationship between nutritional status and frailty in hospitalized older patients1178-1998https://doaj.org/article/30b56e8fc7e5414799ad7ce9f7bbc9892019-01-01T00:00:00Zhttps://www.dovepress.com/relationship-between-nutritional-status-and-frailty-in-hospitalized-ol-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Xiufang Hong,1,2 Jing Yan,1 Liyu Xu,1 Shanshan Shen,1 Xingkun Zeng,1 Lingyan Chen1 1Department of Geriatrics, Zhejiang Hospital, Hangzhou 310013, People’s Republic of China; 2The Second School of Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, People’s Republic of China Objective: The definition of frailty still lacks quantitative biomarkers. This study aimed to investigate the relationship between nutrition-related biomarkers and frailty in hospitalized older patients.Materials and methods: This is a cross-sectional study including 380 hospitalized older patients. The patients were categorized as nonfrail (n=140), prefrail (n=81), and frail (n=159) by the criteria of frailty phenotype. The nutritional status was assessed using the mini nutritional assessment-short form (MNA-SF), levels of serum transferrin (TNF), prealbumin (PA), total protein (TP), albumin (ALB), retinol-binding protein (RBP), and hemoglobin (Hb).Results: The grip strength, levels of serum TFN, TP, ALB, Hb, and MNA-SF scores all decreased significantly in the order of nonfrail, prefrail, and frail groups (P<0.01). Older ages, more fall incidents, and higher polypharmacy ratio were observed in the frail and prefrail groups than in the nonfrail group (P<0.05). Univariate logistic regression analysis showed that frailty was positively related to age, polypharmacy, fall history, nutritional status, levels of TFN, PA, TP, ALB, RBP, and Hb, but was negatively related to grip strength. Ordinal logistic regression analysis showed that older patients who were well nourished, with higher levels of TFN, TP, and ALB were less likely to develop into frailty.Conclusion: Hospitalized older patients with better nutritional status and higher levels of TFN, TP, and ALB were less likely to develop into frailty. These nutrition-related biomarkers may be used for the evaluation of nutritional status and frailty in older patients. Keywords: frailty, nutrition, malnutrition, frailty phenotype, elderlyHong XYan JXu LShen SZeng XChen LDove Medical Pressarticlefrailtynutritionmalnutritionfrailty phenotypeGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 14, Pp 105-111 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	frailty nutrition malnutrition frailty phenotype Geriatrics RC952-954.6
spellingShingle	frailty nutrition malnutrition frailty phenotype Geriatrics RC952-954.6 Hong X Yan J Xu L Shen S Zeng X Chen L Relationship between nutritional status and frailty in hospitalized older patients
description	Xiufang Hong,1,2 Jing Yan,1 Liyu Xu,1 Shanshan Shen,1 Xingkun Zeng,1 Lingyan Chen1 1Department of Geriatrics, Zhejiang Hospital, Hangzhou 310013, People’s Republic of China; 2The Second School of Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, People’s Republic of China Objective: The definition of frailty still lacks quantitative biomarkers. This study aimed to investigate the relationship between nutrition-related biomarkers and frailty in hospitalized older patients.Materials and methods: This is a cross-sectional study including 380 hospitalized older patients. The patients were categorized as nonfrail (n=140), prefrail (n=81), and frail (n=159) by the criteria of frailty phenotype. The nutritional status was assessed using the mini nutritional assessment-short form (MNA-SF), levels of serum transferrin (TNF), prealbumin (PA), total protein (TP), albumin (ALB), retinol-binding protein (RBP), and hemoglobin (Hb).Results: The grip strength, levels of serum TFN, TP, ALB, Hb, and MNA-SF scores all decreased significantly in the order of nonfrail, prefrail, and frail groups (P<0.01). Older ages, more fall incidents, and higher polypharmacy ratio were observed in the frail and prefrail groups than in the nonfrail group (P<0.05). Univariate logistic regression analysis showed that frailty was positively related to age, polypharmacy, fall history, nutritional status, levels of TFN, PA, TP, ALB, RBP, and Hb, but was negatively related to grip strength. Ordinal logistic regression analysis showed that older patients who were well nourished, with higher levels of TFN, TP, and ALB were less likely to develop into frailty.Conclusion: Hospitalized older patients with better nutritional status and higher levels of TFN, TP, and ALB were less likely to develop into frailty. These nutrition-related biomarkers may be used for the evaluation of nutritional status and frailty in older patients. Keywords: frailty, nutrition, malnutrition, frailty phenotype, elderly
format	article
author	Hong X Yan J Xu L Shen S Zeng X Chen L
author_facet	Hong X Yan J Xu L Shen S Zeng X Chen L
author_sort	Hong X
title	Relationship between nutritional status and frailty in hospitalized older patients
title_short	Relationship between nutritional status and frailty in hospitalized older patients
title_full	Relationship between nutritional status and frailty in hospitalized older patients
title_fullStr	Relationship between nutritional status and frailty in hospitalized older patients
title_full_unstemmed	Relationship between nutritional status and frailty in hospitalized older patients
title_sort	relationship between nutritional status and frailty in hospitalized older patients
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/30b56e8fc7e5414799ad7ce9f7bbc989
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Relationship between nutritional status and frailty in hospitalized older patients

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