Plasma proteomics reveals markers of metabolic stress in HIV infected children with severe acute malnutrition

Abstract HIV infection affects up to 30% of children presenting with severe acute malnutrition (SAM) in Africa and is associated with increased mortality. Children with SAM are treated similarly regardless of HIV status, although mechanisms of nutritional recovery in HIV and/or SAM are not well unde...

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Autores principales:	Gerard Bryan Gonzales, James M. Njunge, Bonface M. Gichuki, Bijun Wen, Isabel Potani, Wieger Voskuijl, Robert H. J. Bandsma, James A. Berkley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/30b70b931331474cb60178c3f2da80ff
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spelling	oai:doaj.org-article:30b70b931331474cb60178c3f2da80ff2021-12-02T15:39:58ZPlasma proteomics reveals markers of metabolic stress in HIV infected children with severe acute malnutrition10.1038/s41598-020-68143-72045-2322https://doaj.org/article/30b70b931331474cb60178c3f2da80ff2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-68143-7https://doaj.org/toc/2045-2322Abstract HIV infection affects up to 30% of children presenting with severe acute malnutrition (SAM) in Africa and is associated with increased mortality. Children with SAM are treated similarly regardless of HIV status, although mechanisms of nutritional recovery in HIV and/or SAM are not well understood. We performed a secondary analysis of a clinical trial and plasma proteomics data among children with complicated SAM in Kenya and Malawi. Compared to children with SAM without HIV (n = 113), HIV-infected children (n = 54) had evidence (false discovery rate (FDR) corrected p < 0.05) of metabolic stress, including enriched pathways related to inflammation and lipid metabolism. Moreover, we observed reduced plasma levels of zinc-α-2-glycoprotein, butyrylcholinesterase, and increased levels of complement C2 resembling findings in metabolic syndrome, diabetes and other non-communicable diseases. HIV was also associated (FDR corrected p < 0.05) with higher plasma levels of inflammatory chemokines. Considering evidence of biomarkers of metabolic stress, it is of potential concern that our current treatment strategy for SAM regardless of HIV status involves a high-fat therapeutic diet. The results of this study suggest a need for clinical trials of therapeutic foods that meet the specific metabolic needs of children with HIV and SAM.Gerard Bryan GonzalesJames M. NjungeBonface M. GichukiBijun WenIsabel PotaniWieger VoskuijlRobert H. J. BandsmaJames A. BerkleyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gerard Bryan Gonzales James M. Njunge Bonface M. Gichuki Bijun Wen Isabel Potani Wieger Voskuijl Robert H. J. Bandsma James A. Berkley Plasma proteomics reveals markers of metabolic stress in HIV infected children with severe acute malnutrition
description	Abstract HIV infection affects up to 30% of children presenting with severe acute malnutrition (SAM) in Africa and is associated with increased mortality. Children with SAM are treated similarly regardless of HIV status, although mechanisms of nutritional recovery in HIV and/or SAM are not well understood. We performed a secondary analysis of a clinical trial and plasma proteomics data among children with complicated SAM in Kenya and Malawi. Compared to children with SAM without HIV (n = 113), HIV-infected children (n = 54) had evidence (false discovery rate (FDR) corrected p < 0.05) of metabolic stress, including enriched pathways related to inflammation and lipid metabolism. Moreover, we observed reduced plasma levels of zinc-α-2-glycoprotein, butyrylcholinesterase, and increased levels of complement C2 resembling findings in metabolic syndrome, diabetes and other non-communicable diseases. HIV was also associated (FDR corrected p < 0.05) with higher plasma levels of inflammatory chemokines. Considering evidence of biomarkers of metabolic stress, it is of potential concern that our current treatment strategy for SAM regardless of HIV status involves a high-fat therapeutic diet. The results of this study suggest a need for clinical trials of therapeutic foods that meet the specific metabolic needs of children with HIV and SAM.
format	article
author	Gerard Bryan Gonzales James M. Njunge Bonface M. Gichuki Bijun Wen Isabel Potani Wieger Voskuijl Robert H. J. Bandsma James A. Berkley
author_facet	Gerard Bryan Gonzales James M. Njunge Bonface M. Gichuki Bijun Wen Isabel Potani Wieger Voskuijl Robert H. J. Bandsma James A. Berkley
author_sort	Gerard Bryan Gonzales
title	Plasma proteomics reveals markers of metabolic stress in HIV infected children with severe acute malnutrition
title_short	Plasma proteomics reveals markers of metabolic stress in HIV infected children with severe acute malnutrition
title_full	Plasma proteomics reveals markers of metabolic stress in HIV infected children with severe acute malnutrition
title_fullStr	Plasma proteomics reveals markers of metabolic stress in HIV infected children with severe acute malnutrition
title_full_unstemmed	Plasma proteomics reveals markers of metabolic stress in HIV infected children with severe acute malnutrition
title_sort	plasma proteomics reveals markers of metabolic stress in hiv infected children with severe acute malnutrition
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/30b70b931331474cb60178c3f2da80ff
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Plasma proteomics reveals markers of metabolic stress in HIV infected children with severe acute malnutrition

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