Genomic landscape of high-grade meningiomas

Brain tumors: uncovering genomic disruption in meningiomas Meningiomas, which arise from the tissue surrounding the brain and spinal cord, are the most common primary brain tumor in adults. The majority of these are slow-growing and amenable to surgical resection, if treatment is indicated. However,...

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Autores principales:	Wenya Linda Bi, Noah F. Greenwald, Malak Abedalthagafi, Jeremiah Wala, Will J. Gibson, Pankaj K. Agarwalla, Peleg Horowitz, Steven E. Schumacher, Ekaterina Esaulova, Yu Mei, Aaron Chevalier, Matthew A. Ducar, Aaron R. Thorner, Paul van Hummelen, Anat O. Stemmer-Rachamimov, Maksym Artyomov, Ossama Al-Mefty, Gavin P. Dunn, Sandro Santagata, Ian F. Dunn, Rameen Beroukhim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Genetics QH426-470
Acceso en línea:	https://doaj.org/article/30b733f570624d2fb8c0cba27d4db819
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spelling	oai:doaj.org-article:30b733f570624d2fb8c0cba27d4db8192021-12-02T16:08:59ZGenomic landscape of high-grade meningiomas10.1038/s41525-017-0014-72056-7944https://doaj.org/article/30b733f570624d2fb8c0cba27d4db8192017-04-01T00:00:00Zhttps://doi.org/10.1038/s41525-017-0014-7https://doaj.org/toc/2056-7944Brain tumors: uncovering genomic disruption in meningiomas Meningiomas, which arise from the tissue surrounding the brain and spinal cord, are the most common primary brain tumor in adults. The majority of these are slow-growing and amenable to surgical resection, if treatment is indicated. However, a subset of aggressive meningiomas are considered high-grade, producing significantly worse mortality. In a first study of its kind, Drs. Wenya Linda Bi, Ian Dunn, Sandro Santagata, Rameen Beroukhim, and colleagues at Harvard Medical School sequenced the genomes of 134 high-grade meningiomas and compared their makeup with lower-grade meningiomas. They found that aggressive tumors were more likely to harbor mutations in the NF2 gene and exhibit widespread genomic disruption. They also harbored an elevated rate of predicted immunogenic mutations, with implications for the use of immuno-modulatory therapies.Wenya Linda BiNoah F. GreenwaldMalak AbedalthagafiJeremiah WalaWill J. GibsonPankaj K. AgarwallaPeleg HorowitzSteven E. SchumacherEkaterina EsaulovaYu MeiAaron ChevalierMatthew A. DucarAaron R. ThornerPaul van HummelenAnat O. Stemmer-RachamimovMaksym ArtyomovOssama Al-MeftyGavin P. DunnSandro SantagataIan F. DunnRameen BeroukhimNature PortfolioarticleMedicineRGeneticsQH426-470ENnpj Genomic Medicine, Vol 2, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Genetics QH426-470
spellingShingle	Medicine R Genetics QH426-470 Wenya Linda Bi Noah F. Greenwald Malak Abedalthagafi Jeremiah Wala Will J. Gibson Pankaj K. Agarwalla Peleg Horowitz Steven E. Schumacher Ekaterina Esaulova Yu Mei Aaron Chevalier Matthew A. Ducar Aaron R. Thorner Paul van Hummelen Anat O. Stemmer-Rachamimov Maksym Artyomov Ossama Al-Mefty Gavin P. Dunn Sandro Santagata Ian F. Dunn Rameen Beroukhim Genomic landscape of high-grade meningiomas
description	Brain tumors: uncovering genomic disruption in meningiomas Meningiomas, which arise from the tissue surrounding the brain and spinal cord, are the most common primary brain tumor in adults. The majority of these are slow-growing and amenable to surgical resection, if treatment is indicated. However, a subset of aggressive meningiomas are considered high-grade, producing significantly worse mortality. In a first study of its kind, Drs. Wenya Linda Bi, Ian Dunn, Sandro Santagata, Rameen Beroukhim, and colleagues at Harvard Medical School sequenced the genomes of 134 high-grade meningiomas and compared their makeup with lower-grade meningiomas. They found that aggressive tumors were more likely to harbor mutations in the NF2 gene and exhibit widespread genomic disruption. They also harbored an elevated rate of predicted immunogenic mutations, with implications for the use of immuno-modulatory therapies.
format	article
author	Wenya Linda Bi Noah F. Greenwald Malak Abedalthagafi Jeremiah Wala Will J. Gibson Pankaj K. Agarwalla Peleg Horowitz Steven E. Schumacher Ekaterina Esaulova Yu Mei Aaron Chevalier Matthew A. Ducar Aaron R. Thorner Paul van Hummelen Anat O. Stemmer-Rachamimov Maksym Artyomov Ossama Al-Mefty Gavin P. Dunn Sandro Santagata Ian F. Dunn Rameen Beroukhim
author_facet	Wenya Linda Bi Noah F. Greenwald Malak Abedalthagafi Jeremiah Wala Will J. Gibson Pankaj K. Agarwalla Peleg Horowitz Steven E. Schumacher Ekaterina Esaulova Yu Mei Aaron Chevalier Matthew A. Ducar Aaron R. Thorner Paul van Hummelen Anat O. Stemmer-Rachamimov Maksym Artyomov Ossama Al-Mefty Gavin P. Dunn Sandro Santagata Ian F. Dunn Rameen Beroukhim
author_sort	Wenya Linda Bi
title	Genomic landscape of high-grade meningiomas
title_short	Genomic landscape of high-grade meningiomas
title_full	Genomic landscape of high-grade meningiomas
title_fullStr	Genomic landscape of high-grade meningiomas
title_full_unstemmed	Genomic landscape of high-grade meningiomas
title_sort	genomic landscape of high-grade meningiomas
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/30b733f570624d2fb8c0cba27d4db819
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Genomic landscape of high-grade meningiomas

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