Practical considerations for Ultraviolet-C radiation mediated decontamination of N95 respirator against SARS-CoV-2 virus.

Decontaminating N95 respirators for reuse could mitigate shortages during the COVID-19 pandemic. Although the United States Center for Disease Control has identified Ultraviolet-C irradiation as one of the most promising methods for N95 decontamination, very few studies have evaluated the efficacy o...

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Autores principales:	Guillaume R Golovkine, Allison W Roberts, Chase Cooper, Sebastian Riano, Angela M DiCiccio, Daniel L Worthington, Jeffrey P Clarkson, Michael Krames, Jianping Zhang, Ying Gao, Ling Zhou, Scott B Biering, Sarah A Stanley
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/30b972ca089242bc8a9dde6d2e24f3e9
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spelling	oai:doaj.org-article:30b972ca089242bc8a9dde6d2e24f3e92021-11-25T06:18:58ZPractical considerations for Ultraviolet-C radiation mediated decontamination of N95 respirator against SARS-CoV-2 virus.1932-620310.1371/journal.pone.0258336https://doaj.org/article/30b972ca089242bc8a9dde6d2e24f3e92021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258336https://doaj.org/toc/1932-6203Decontaminating N95 respirators for reuse could mitigate shortages during the COVID-19 pandemic. Although the United States Center for Disease Control has identified Ultraviolet-C irradiation as one of the most promising methods for N95 decontamination, very few studies have evaluated the efficacy of Ultraviolet-C for SARS-CoV-2 inactivation. In addition, most decontamination studies are performed using mask coupons that do not recapitulate the complexity of whole masks. We sought to directly evaluate the efficacy of Ultraviolet-C mediated inactivation of SARS-CoV-2 on N95 respirators. To that end we created a portable UV-C light-emitting diode disinfection chamber and tested decontamination of SARS-CoV-2 at different sites on two models of N95 respirator. We found that decontamination efficacy depends on mask model, material and location of the contamination on the mask. Our results emphasize the need for caution when interpreting efficacy data of UV-C decontamination methods.Guillaume R GolovkineAllison W RobertsChase CooperSebastian RianoAngela M DiCiccioDaniel L WorthingtonJeffrey P ClarksonMichael KramesJianping ZhangYing GaoLing ZhouScott B BieringSarah A StanleyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258336 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Guillaume R Golovkine Allison W Roberts Chase Cooper Sebastian Riano Angela M DiCiccio Daniel L Worthington Jeffrey P Clarkson Michael Krames Jianping Zhang Ying Gao Ling Zhou Scott B Biering Sarah A Stanley Practical considerations for Ultraviolet-C radiation mediated decontamination of N95 respirator against SARS-CoV-2 virus.
description	Decontaminating N95 respirators for reuse could mitigate shortages during the COVID-19 pandemic. Although the United States Center for Disease Control has identified Ultraviolet-C irradiation as one of the most promising methods for N95 decontamination, very few studies have evaluated the efficacy of Ultraviolet-C for SARS-CoV-2 inactivation. In addition, most decontamination studies are performed using mask coupons that do not recapitulate the complexity of whole masks. We sought to directly evaluate the efficacy of Ultraviolet-C mediated inactivation of SARS-CoV-2 on N95 respirators. To that end we created a portable UV-C light-emitting diode disinfection chamber and tested decontamination of SARS-CoV-2 at different sites on two models of N95 respirator. We found that decontamination efficacy depends on mask model, material and location of the contamination on the mask. Our results emphasize the need for caution when interpreting efficacy data of UV-C decontamination methods.
format	article
author	Guillaume R Golovkine Allison W Roberts Chase Cooper Sebastian Riano Angela M DiCiccio Daniel L Worthington Jeffrey P Clarkson Michael Krames Jianping Zhang Ying Gao Ling Zhou Scott B Biering Sarah A Stanley
author_facet	Guillaume R Golovkine Allison W Roberts Chase Cooper Sebastian Riano Angela M DiCiccio Daniel L Worthington Jeffrey P Clarkson Michael Krames Jianping Zhang Ying Gao Ling Zhou Scott B Biering Sarah A Stanley
author_sort	Guillaume R Golovkine
title	Practical considerations for Ultraviolet-C radiation mediated decontamination of N95 respirator against SARS-CoV-2 virus.
title_short	Practical considerations for Ultraviolet-C radiation mediated decontamination of N95 respirator against SARS-CoV-2 virus.
title_full	Practical considerations for Ultraviolet-C radiation mediated decontamination of N95 respirator against SARS-CoV-2 virus.
title_fullStr	Practical considerations for Ultraviolet-C radiation mediated decontamination of N95 respirator against SARS-CoV-2 virus.
title_full_unstemmed	Practical considerations for Ultraviolet-C radiation mediated decontamination of N95 respirator against SARS-CoV-2 virus.
title_sort	practical considerations for ultraviolet-c radiation mediated decontamination of n95 respirator against sars-cov-2 virus.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/30b972ca089242bc8a9dde6d2e24f3e9
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Practical considerations for Ultraviolet-C radiation mediated decontamination of N95 respirator against SARS-CoV-2 virus.

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