Survey of Molecular Mechanisms of Hyperbaric Oxygen in Tissue Repair

For more than six decades, hyperbaric oxygen (HBO) has been used for a variety of indications involving tissue repair. These indications comprise a wide range of diseases ranging from intoxications to ischemia-reperfusion injury, crush syndrome, central nervous injury, radiation-induced tissue damag...

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Autores principales:	Joerg Lindenmann, Christian Smolle, Lars-Peter Kamolz, Freyja Maria Smolle-Juettner, Wolfgang F. Graier
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hyperbaric oxygenation (HBO) reactive oxygen species (ROS) oxidative stress tissue repair molecular mechanism transcription Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/30b9c637161f44ac8b3ba989e7ccbae3
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spelling	oai:doaj.org-article:30b9c637161f44ac8b3ba989e7ccbae32021-11-11T17:12:32ZSurvey of Molecular Mechanisms of Hyperbaric Oxygen in Tissue Repair10.3390/ijms2221117541422-00671661-6596https://doaj.org/article/30b9c637161f44ac8b3ba989e7ccbae32021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11754https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067For more than six decades, hyperbaric oxygen (HBO) has been used for a variety of indications involving tissue repair. These indications comprise a wide range of diseases ranging from intoxications to ischemia-reperfusion injury, crush syndrome, central nervous injury, radiation-induced tissue damage, burn injury and chronic wounds. In a systematic review, the molecular mechanisms triggered by HBO described within the last two decades were compiled. They cover a wide range of pathways, including transcription, cell-to-cell contacts, structure, adhesion and transmigration, vascular signaling and response to oxidative stress, apoptosis, autophagy and cell death, as well as inflammatory processes. By analyzing 71 predominantly experimental publications, we established an overview of the current concepts regarding the molecular mechanisms underlying the effects of HBO. We considered both the abovementioned pathways and their role in various applications and indications.Joerg LindenmannChristian SmolleLars-Peter KamolzFreyja Maria Smolle-JuettnerWolfgang F. GraierMDPI AGarticlehyperbaric oxygenation (HBO)reactive oxygen species (ROS)oxidative stresstissue repairmolecular mechanismtranscriptionBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11754, p 11754 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hyperbaric oxygenation (HBO) reactive oxygen species (ROS) oxidative stress tissue repair molecular mechanism transcription Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	hyperbaric oxygenation (HBO) reactive oxygen species (ROS) oxidative stress tissue repair molecular mechanism transcription Biology (General) QH301-705.5 Chemistry QD1-999 Joerg Lindenmann Christian Smolle Lars-Peter Kamolz Freyja Maria Smolle-Juettner Wolfgang F. Graier Survey of Molecular Mechanisms of Hyperbaric Oxygen in Tissue Repair
description	For more than six decades, hyperbaric oxygen (HBO) has been used for a variety of indications involving tissue repair. These indications comprise a wide range of diseases ranging from intoxications to ischemia-reperfusion injury, crush syndrome, central nervous injury, radiation-induced tissue damage, burn injury and chronic wounds. In a systematic review, the molecular mechanisms triggered by HBO described within the last two decades were compiled. They cover a wide range of pathways, including transcription, cell-to-cell contacts, structure, adhesion and transmigration, vascular signaling and response to oxidative stress, apoptosis, autophagy and cell death, as well as inflammatory processes. By analyzing 71 predominantly experimental publications, we established an overview of the current concepts regarding the molecular mechanisms underlying the effects of HBO. We considered both the abovementioned pathways and their role in various applications and indications.
format	article
author	Joerg Lindenmann Christian Smolle Lars-Peter Kamolz Freyja Maria Smolle-Juettner Wolfgang F. Graier
author_facet	Joerg Lindenmann Christian Smolle Lars-Peter Kamolz Freyja Maria Smolle-Juettner Wolfgang F. Graier
author_sort	Joerg Lindenmann
title	Survey of Molecular Mechanisms of Hyperbaric Oxygen in Tissue Repair
title_short	Survey of Molecular Mechanisms of Hyperbaric Oxygen in Tissue Repair
title_full	Survey of Molecular Mechanisms of Hyperbaric Oxygen in Tissue Repair
title_fullStr	Survey of Molecular Mechanisms of Hyperbaric Oxygen in Tissue Repair
title_full_unstemmed	Survey of Molecular Mechanisms of Hyperbaric Oxygen in Tissue Repair
title_sort	survey of molecular mechanisms of hyperbaric oxygen in tissue repair
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/30b9c637161f44ac8b3ba989e7ccbae3
work_keys_str_mv	AT joerglindenmann surveyofmolecularmechanismsofhyperbaricoxygenintissuerepair AT christiansmolle surveyofmolecularmechanismsofhyperbaricoxygenintissuerepair AT larspeterkamolz surveyofmolecularmechanismsofhyperbaricoxygenintissuerepair AT freyjamariasmollejuettner surveyofmolecularmechanismsofhyperbaricoxygenintissuerepair AT wolfgangfgraier surveyofmolecularmechanismsofhyperbaricoxygenintissuerepair
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Survey of Molecular Mechanisms of Hyperbaric Oxygen in Tissue Repair

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