Metal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp3)–H bonds

Direct remote C–H functionalization of aliphatic alcohols via alkoxy radicals is largely unexplored. Here, the authors report the C(sp3)-heteroaryl bond formation in aliphatic alcohols mediated by alkoxy radicals formed with a hypervalent iodine reagent.

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Autores principales:	Xinxin Wu, Hong Zhang, Nana Tang, Zhen Wu, Dongping Wang, Meishan Ji, Yan Xu, Min Wang, Chen Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/30bbd4ff5f03484f95eace791194e101
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spelling	oai:doaj.org-article:30bbd4ff5f03484f95eace791194e1012021-12-02T14:38:53ZMetal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp3)–H bonds10.1038/s41467-018-05522-92041-1723https://doaj.org/article/30bbd4ff5f03484f95eace791194e1012018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05522-9https://doaj.org/toc/2041-1723Direct remote C–H functionalization of aliphatic alcohols via alkoxy radicals is largely unexplored. Here, the authors report the C(sp3)-heteroaryl bond formation in aliphatic alcohols mediated by alkoxy radicals formed with a hypervalent iodine reagent.Xinxin WuHong ZhangNana TangZhen WuDongping WangMeishan JiYan XuMin WangChen ZhuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xinxin Wu Hong Zhang Nana Tang Zhen Wu Dongping Wang Meishan Ji Yan Xu Min Wang Chen Zhu Metal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp3)–H bonds
description	Direct remote C–H functionalization of aliphatic alcohols via alkoxy radicals is largely unexplored. Here, the authors report the C(sp3)-heteroaryl bond formation in aliphatic alcohols mediated by alkoxy radicals formed with a hypervalent iodine reagent.
format	article
author	Xinxin Wu Hong Zhang Nana Tang Zhen Wu Dongping Wang Meishan Ji Yan Xu Min Wang Chen Zhu
author_facet	Xinxin Wu Hong Zhang Nana Tang Zhen Wu Dongping Wang Meishan Ji Yan Xu Min Wang Chen Zhu
author_sort	Xinxin Wu
title	Metal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp3)–H bonds
title_short	Metal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp3)–H bonds
title_full	Metal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp3)–H bonds
title_fullStr	Metal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp3)–H bonds
title_full_unstemmed	Metal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp3)–H bonds
title_sort	metal-free alcohol-directed regioselective heteroarylation of remote unactivated c(sp3)–h bonds
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/30bbd4ff5f03484f95eace791194e101
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Metal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp3)–H bonds

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