Metal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp3)–H bonds

Direct remote C–H functionalization of aliphatic alcohols via alkoxy radicals is largely unexplored. Here, the authors report the C(sp3)-heteroaryl bond formation in aliphatic alcohols mediated by alkoxy radicals formed with a hypervalent iodine reagent.

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Autores principales: Xinxin Wu, Hong Zhang, Nana Tang, Zhen Wu, Dongping Wang, Meishan Ji, Yan Xu, Min Wang, Chen Zhu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/30bbd4ff5f03484f95eace791194e101
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spelling oai:doaj.org-article:30bbd4ff5f03484f95eace791194e1012021-12-02T14:38:53ZMetal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp3)–H bonds10.1038/s41467-018-05522-92041-1723https://doaj.org/article/30bbd4ff5f03484f95eace791194e1012018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05522-9https://doaj.org/toc/2041-1723Direct remote C–H functionalization of aliphatic alcohols via alkoxy radicals is largely unexplored. Here, the authors report the C(sp3)-heteroaryl bond formation in aliphatic alcohols mediated by alkoxy radicals formed with a hypervalent iodine reagent.Xinxin WuHong ZhangNana TangZhen WuDongping WangMeishan JiYan XuMin WangChen ZhuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xinxin Wu
Hong Zhang
Nana Tang
Zhen Wu
Dongping Wang
Meishan Ji
Yan Xu
Min Wang
Chen Zhu
Metal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp3)–H bonds
description Direct remote C–H functionalization of aliphatic alcohols via alkoxy radicals is largely unexplored. Here, the authors report the C(sp3)-heteroaryl bond formation in aliphatic alcohols mediated by alkoxy radicals formed with a hypervalent iodine reagent.
format article
author Xinxin Wu
Hong Zhang
Nana Tang
Zhen Wu
Dongping Wang
Meishan Ji
Yan Xu
Min Wang
Chen Zhu
author_facet Xinxin Wu
Hong Zhang
Nana Tang
Zhen Wu
Dongping Wang
Meishan Ji
Yan Xu
Min Wang
Chen Zhu
author_sort Xinxin Wu
title Metal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp3)–H bonds
title_short Metal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp3)–H bonds
title_full Metal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp3)–H bonds
title_fullStr Metal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp3)–H bonds
title_full_unstemmed Metal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp3)–H bonds
title_sort metal-free alcohol-directed regioselective heteroarylation of remote unactivated c(sp3)–h bonds
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/30bbd4ff5f03484f95eace791194e101
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