Metal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp3)–H bonds
Direct remote C–H functionalization of aliphatic alcohols via alkoxy radicals is largely unexplored. Here, the authors report the C(sp3)-heteroaryl bond formation in aliphatic alcohols mediated by alkoxy radicals formed with a hypervalent iodine reagent.
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Nature Portfolio
2018
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oai:doaj.org-article:30bbd4ff5f03484f95eace791194e1012021-12-02T14:38:53ZMetal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp3)–H bonds10.1038/s41467-018-05522-92041-1723https://doaj.org/article/30bbd4ff5f03484f95eace791194e1012018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05522-9https://doaj.org/toc/2041-1723Direct remote C–H functionalization of aliphatic alcohols via alkoxy radicals is largely unexplored. Here, the authors report the C(sp3)-heteroaryl bond formation in aliphatic alcohols mediated by alkoxy radicals formed with a hypervalent iodine reagent.Xinxin WuHong ZhangNana TangZhen WuDongping WangMeishan JiYan XuMin WangChen ZhuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018) |
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Science Q Xinxin Wu Hong Zhang Nana Tang Zhen Wu Dongping Wang Meishan Ji Yan Xu Min Wang Chen Zhu Metal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp3)–H bonds |
description |
Direct remote C–H functionalization of aliphatic alcohols via alkoxy radicals is largely unexplored. Here, the authors report the C(sp3)-heteroaryl bond formation in aliphatic alcohols mediated by alkoxy radicals formed with a hypervalent iodine reagent. |
format |
article |
author |
Xinxin Wu Hong Zhang Nana Tang Zhen Wu Dongping Wang Meishan Ji Yan Xu Min Wang Chen Zhu |
author_facet |
Xinxin Wu Hong Zhang Nana Tang Zhen Wu Dongping Wang Meishan Ji Yan Xu Min Wang Chen Zhu |
author_sort |
Xinxin Wu |
title |
Metal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp3)–H bonds |
title_short |
Metal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp3)–H bonds |
title_full |
Metal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp3)–H bonds |
title_fullStr |
Metal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp3)–H bonds |
title_full_unstemmed |
Metal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp3)–H bonds |
title_sort |
metal-free alcohol-directed regioselective heteroarylation of remote unactivated c(sp3)–h bonds |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/30bbd4ff5f03484f95eace791194e101 |
work_keys_str_mv |
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_version_ |
1718390824009465856 |