Epidemiologic profile of hepatitis C virus infection and genotype distribution in Burkina Faso: a systematic review with meta-analysis

Abstract Background Detailed characteristics of Hepatitis C virus (HCV) infection in Burkina Faso are scarce. The main aim of this study was to assess HCV seroprevalence in various settings and populations at risk in Burkina Faso between 1990 and 2020. Secondary objectives included the prevalence of...

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Autores principales:	Serge Ouoba, Jean Claude Romaric Pingdwinde Ouedraogo, Moussa Lingani, Bunthen E, Md Razeen Ashraf Hussain, Ko Ko, Shintaro Nagashima, Aya Sugiyama, Tomoyuki Akita, Halidou Tinto, Junko Tanaka
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Hepatitis C Seroprevalence Prevalence Genotype Systematic review Burkina Faso Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/30bc2647cab440b3965557b205803c6e
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spelling	oai:doaj.org-article:30bc2647cab440b3965557b205803c6e2021-11-08T11:18:37ZEpidemiologic profile of hepatitis C virus infection and genotype distribution in Burkina Faso: a systematic review with meta-analysis10.1186/s12879-021-06817-x1471-2334https://doaj.org/article/30bc2647cab440b3965557b205803c6e2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12879-021-06817-xhttps://doaj.org/toc/1471-2334Abstract Background Detailed characteristics of Hepatitis C virus (HCV) infection in Burkina Faso are scarce. The main aim of this study was to assess HCV seroprevalence in various settings and populations at risk in Burkina Faso between 1990 and 2020. Secondary objectives included the prevalence of HCV Ribonucleic acid (RNA) and the distribution of HCV genotypes. Methods A systematic database search, supplemented by a manual search, was conducted in PubMed, Web of Science, Scopus, and African Index Medicus. Studies reporting HCV seroprevalence data in low and high-risk populations in Burkina Faso were included, and a random-effects meta-analysis was applied. Risk of bias was assessed using the Joanna Briggs institute checklist. Results Low-risk populations were examined in 31 studies involving a total of 168,151 subjects, of whom 8330 were positive for HCV antibodies. Six studies included a total of 1484 high-risk persons, and 96 had antibodies to HCV. The pooled seroprevalence in low-risk populations was 3.72% (95% CI: 3.20–4.28) and 4.75% (95% CI: 1.79–8.94) in high-risk groups. A non-significant decreasing trend was observed over the study period. Seven studies tested HCV RNA in a total of 4759 individuals at low risk for HCV infection, and 81 were positive. The meta-analysis of HCV RNA yielded a pooled prevalence of 1.65% (95% CI: 0.74–2.89%) in low-risk populations, which is assumed to be indicative of HCV prevalence in the general population of Burkina Faso and suggests that about 301,174 people are active HCV carriers in the country. Genotypes 2 and 1 were the most frequent, with 60.3% and 25.0%, respectively. Conclusions HCV seroprevalence is intermediate in Burkina Faso and indicates the need to implement effective control strategies. There is a paucity of data at the national level and for rural and high-risk populations. General population screening and linkage to care are recommended, with special attention to rural and high-risk populations.Serge OuobaJean Claude Romaric Pingdwinde OuedraogoMoussa LinganiBunthen EMd Razeen Ashraf HussainKo KoShintaro NagashimaAya SugiyamaTomoyuki AkitaHalidou TintoJunko TanakaBMCarticleHepatitis CSeroprevalencePrevalenceGenotypeSystematic reviewBurkina FasoInfectious and parasitic diseasesRC109-216ENBMC Infectious Diseases, Vol 21, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hepatitis C Seroprevalence Prevalence Genotype Systematic review Burkina Faso Infectious and parasitic diseases RC109-216
spellingShingle	Hepatitis C Seroprevalence Prevalence Genotype Systematic review Burkina Faso Infectious and parasitic diseases RC109-216 Serge Ouoba Jean Claude Romaric Pingdwinde Ouedraogo Moussa Lingani Bunthen E Md Razeen Ashraf Hussain Ko Ko Shintaro Nagashima Aya Sugiyama Tomoyuki Akita Halidou Tinto Junko Tanaka Epidemiologic profile of hepatitis C virus infection and genotype distribution in Burkina Faso: a systematic review with meta-analysis
description	Abstract Background Detailed characteristics of Hepatitis C virus (HCV) infection in Burkina Faso are scarce. The main aim of this study was to assess HCV seroprevalence in various settings and populations at risk in Burkina Faso between 1990 and 2020. Secondary objectives included the prevalence of HCV Ribonucleic acid (RNA) and the distribution of HCV genotypes. Methods A systematic database search, supplemented by a manual search, was conducted in PubMed, Web of Science, Scopus, and African Index Medicus. Studies reporting HCV seroprevalence data in low and high-risk populations in Burkina Faso were included, and a random-effects meta-analysis was applied. Risk of bias was assessed using the Joanna Briggs institute checklist. Results Low-risk populations were examined in 31 studies involving a total of 168,151 subjects, of whom 8330 were positive for HCV antibodies. Six studies included a total of 1484 high-risk persons, and 96 had antibodies to HCV. The pooled seroprevalence in low-risk populations was 3.72% (95% CI: 3.20–4.28) and 4.75% (95% CI: 1.79–8.94) in high-risk groups. A non-significant decreasing trend was observed over the study period. Seven studies tested HCV RNA in a total of 4759 individuals at low risk for HCV infection, and 81 were positive. The meta-analysis of HCV RNA yielded a pooled prevalence of 1.65% (95% CI: 0.74–2.89%) in low-risk populations, which is assumed to be indicative of HCV prevalence in the general population of Burkina Faso and suggests that about 301,174 people are active HCV carriers in the country. Genotypes 2 and 1 were the most frequent, with 60.3% and 25.0%, respectively. Conclusions HCV seroprevalence is intermediate in Burkina Faso and indicates the need to implement effective control strategies. There is a paucity of data at the national level and for rural and high-risk populations. General population screening and linkage to care are recommended, with special attention to rural and high-risk populations.
format	article
author	Serge Ouoba Jean Claude Romaric Pingdwinde Ouedraogo Moussa Lingani Bunthen E Md Razeen Ashraf Hussain Ko Ko Shintaro Nagashima Aya Sugiyama Tomoyuki Akita Halidou Tinto Junko Tanaka
author_facet	Serge Ouoba Jean Claude Romaric Pingdwinde Ouedraogo Moussa Lingani Bunthen E Md Razeen Ashraf Hussain Ko Ko Shintaro Nagashima Aya Sugiyama Tomoyuki Akita Halidou Tinto Junko Tanaka
author_sort	Serge Ouoba
title	Epidemiologic profile of hepatitis C virus infection and genotype distribution in Burkina Faso: a systematic review with meta-analysis
title_short	Epidemiologic profile of hepatitis C virus infection and genotype distribution in Burkina Faso: a systematic review with meta-analysis
title_full	Epidemiologic profile of hepatitis C virus infection and genotype distribution in Burkina Faso: a systematic review with meta-analysis
title_fullStr	Epidemiologic profile of hepatitis C virus infection and genotype distribution in Burkina Faso: a systematic review with meta-analysis
title_full_unstemmed	Epidemiologic profile of hepatitis C virus infection and genotype distribution in Burkina Faso: a systematic review with meta-analysis
title_sort	epidemiologic profile of hepatitis c virus infection and genotype distribution in burkina faso: a systematic review with meta-analysis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/30bc2647cab440b3965557b205803c6e
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Epidemiologic profile of hepatitis C virus infection and genotype distribution in Burkina Faso: a systematic review with meta-analysis

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