TM4SF5-dependent crosstalk between hepatocytes and macrophages to reprogram the inflammatory environment

Summary: Chronic injury to hepatocytes results in inflammation, steatohepatitis, fibrosis, and nonalcoholic fatty liver disease (NAFLD). The tetraspanin TM4SF5 is implicated in fibrosis and cancer. We investigate the role of TM4SF5 in communication between hepatocytes and macrophages (MΦs) and its p...

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Autores principales: Eunmi Kim, Hyejin Um, Jinsoo Park, Jae Woo Jung, Ji Eon Kim, Haesong Lee, Eun-Ae Shin, Yangie Pinanga, Hyejin Lee, Seo Hee Nam, Jung Weon Lee
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Lenguaje:EN
Publicado: Elsevier 2021
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Acceso en línea:https://doaj.org/article/30bc3a81cc954bfe861f776a7c275d30
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spelling oai:doaj.org-article:30bc3a81cc954bfe861f776a7c275d302021-11-18T04:47:58ZTM4SF5-dependent crosstalk between hepatocytes and macrophages to reprogram the inflammatory environment2211-124710.1016/j.celrep.2021.110018https://doaj.org/article/30bc3a81cc954bfe861f776a7c275d302021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S221112472101500Xhttps://doaj.org/toc/2211-1247Summary: Chronic injury to hepatocytes results in inflammation, steatohepatitis, fibrosis, and nonalcoholic fatty liver disease (NAFLD). The tetraspanin TM4SF5 is implicated in fibrosis and cancer. We investigate the role of TM4SF5 in communication between hepatocytes and macrophages (MΦs) and its possible influence on the inflammatory microenvironment that may lead to NAFLD. TM4SF5 induction in differentiated MΦs promotes glucose uptake, glycolysis, and glucose sensitivity, leading to M1-type MΦ activation. Activated M1-type MΦs secrete pro-inflammatory interleukin-6 (IL-6), which induces the secretion of CCL20 and CXCL10 from TM4SF5-positive hepatocytes. Although TM4SF5-dependent secretion of these chemokines enhances glycolysis in M0 MΦs, further chronic exposure reprograms MΦs for an increase in the proportion of M2-type MΦs in the population, which may support diet- and chemical-induced NAFLD progression. We suggest that TM4SF5 expression in MΦs and hepatocytes is critically involved in modulating the inflammatory environment during NAFLD progression.Eunmi KimHyejin UmJinsoo ParkJae Woo JungJi Eon KimHaesong LeeEun-Ae ShinYangie PinangaHyejin LeeSeo Hee NamJung Weon LeeElsevierarticlecytokines/chemokinesdiet animal modelfibrosisglycolysishepatocytesinflammationBiology (General)QH301-705.5ENCell Reports, Vol 37, Iss 7, Pp 110018- (2021)
institution DOAJ
collection DOAJ
language EN
topic cytokines/chemokines
diet animal model
fibrosis
glycolysis
hepatocytes
inflammation
Biology (General)
QH301-705.5
spellingShingle cytokines/chemokines
diet animal model
fibrosis
glycolysis
hepatocytes
inflammation
Biology (General)
QH301-705.5
Eunmi Kim
Hyejin Um
Jinsoo Park
Jae Woo Jung
Ji Eon Kim
Haesong Lee
Eun-Ae Shin
Yangie Pinanga
Hyejin Lee
Seo Hee Nam
Jung Weon Lee
TM4SF5-dependent crosstalk between hepatocytes and macrophages to reprogram the inflammatory environment
description Summary: Chronic injury to hepatocytes results in inflammation, steatohepatitis, fibrosis, and nonalcoholic fatty liver disease (NAFLD). The tetraspanin TM4SF5 is implicated in fibrosis and cancer. We investigate the role of TM4SF5 in communication between hepatocytes and macrophages (MΦs) and its possible influence on the inflammatory microenvironment that may lead to NAFLD. TM4SF5 induction in differentiated MΦs promotes glucose uptake, glycolysis, and glucose sensitivity, leading to M1-type MΦ activation. Activated M1-type MΦs secrete pro-inflammatory interleukin-6 (IL-6), which induces the secretion of CCL20 and CXCL10 from TM4SF5-positive hepatocytes. Although TM4SF5-dependent secretion of these chemokines enhances glycolysis in M0 MΦs, further chronic exposure reprograms MΦs for an increase in the proportion of M2-type MΦs in the population, which may support diet- and chemical-induced NAFLD progression. We suggest that TM4SF5 expression in MΦs and hepatocytes is critically involved in modulating the inflammatory environment during NAFLD progression.
format article
author Eunmi Kim
Hyejin Um
Jinsoo Park
Jae Woo Jung
Ji Eon Kim
Haesong Lee
Eun-Ae Shin
Yangie Pinanga
Hyejin Lee
Seo Hee Nam
Jung Weon Lee
author_facet Eunmi Kim
Hyejin Um
Jinsoo Park
Jae Woo Jung
Ji Eon Kim
Haesong Lee
Eun-Ae Shin
Yangie Pinanga
Hyejin Lee
Seo Hee Nam
Jung Weon Lee
author_sort Eunmi Kim
title TM4SF5-dependent crosstalk between hepatocytes and macrophages to reprogram the inflammatory environment
title_short TM4SF5-dependent crosstalk between hepatocytes and macrophages to reprogram the inflammatory environment
title_full TM4SF5-dependent crosstalk between hepatocytes and macrophages to reprogram the inflammatory environment
title_fullStr TM4SF5-dependent crosstalk between hepatocytes and macrophages to reprogram the inflammatory environment
title_full_unstemmed TM4SF5-dependent crosstalk between hepatocytes and macrophages to reprogram the inflammatory environment
title_sort tm4sf5-dependent crosstalk between hepatocytes and macrophages to reprogram the inflammatory environment
publisher Elsevier
publishDate 2021
url https://doaj.org/article/30bc3a81cc954bfe861f776a7c275d30
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