Elevated Levels of IL-27 Are Associated with Disease Activity in Patients with Crohn’s Disease

Immune disorders play an important role in the pathogenesis of Crohn’s disease (CD). Notably, the increased immune response of Th1 cells and related cytokines is associated with the onset of CD. IL-27 is a newly discovered IL-12-related cytokine, but its expression and clinical significance in CD pa...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xiufang Cui, Chunhua Jiao, Di Wang, Ziping Ye, Jingjing Ma, Nana Tang, Hongjie Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Pathology RB1-214
Acceso en línea:	https://doaj.org/article/30bcd28a9d9148d9880e8bba1a15b7ab
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:30bcd28a9d9148d9880e8bba1a15b7ab
record_format	dspace
spelling	oai:doaj.org-article:30bcd28a9d9148d9880e8bba1a15b7ab2021-11-08T02:36:30ZElevated Levels of IL-27 Are Associated with Disease Activity in Patients with Crohn’s Disease1466-186110.1155/2021/5527627https://doaj.org/article/30bcd28a9d9148d9880e8bba1a15b7ab2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/5527627https://doaj.org/toc/1466-1861Immune disorders play an important role in the pathogenesis of Crohn’s disease (CD). Notably, the increased immune response of Th1 cells and related cytokines is associated with the onset of CD. IL-27 is a newly discovered IL-12-related cytokine, but its expression and clinical significance in CD patients are still controversial. This study is aimed at evaluating the serum levels of IL-27 in CD patients and analyzing their clinical significance. The results indicated that serum levels of IL-27 in CD patients were significantly higher than those in control subjects (median (interquartile range (IQR)): 110.0 (95.0, 145.0) vs. 85.0 (80.0, 95.0) pg/ml, P<0.001). Furthermore, the IL-27 levels significantly increased in CD patients at the active stage compared with CD patients in remission (CDR) (127.5 (100.0, 150.0) vs. 90 (80.0, 110.0) pg/ml, P<0.001). However, there was no difference in IL-27 levels between CDR and control subjects. The levels of IL-27 were positively correlated with Crohn’s disease activity index (CDAI), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), fecal calprotectin (FC), and Simple Endoscopic Score for Crohn’s Disease (SES-CD) and negatively correlated with hemoglobin (Hb) and serum albumin (ALB). IL-27 combined with CRP favored the prediction of CD activity (area under the curve (AUC): 0.88). Additionally, the proportions of Th17 and Th1 cells in peripheral blood were higher in CD patients than in control subjects. Active CD patients exhibited significantly higher proportions of Th17 and Th1 cells than those in remission. Moreover, correlation analysis indicated that the serum levels of IL-27 were positively associated with the frequency of Th17 cells in CD patients (r=0.519, P=0.013) but not associated with the frequency of Th1 cells in CD patients. IL-27 is positively associated with multiple inflammation indicators and may exert a proinflammatory profile by regulating Th17 cell differentiation in the development of Crohn’s disease. In the future, IL-27 combined with CRP is expected to become an important biological marker of CD activity.Xiufang CuiChunhua JiaoDi WangZiping YeJingjing MaNana TangHongjie ZhangHindawi LimitedarticlePathologyRB1-214ENMediators of Inflammation, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pathology RB1-214
spellingShingle	Pathology RB1-214 Xiufang Cui Chunhua Jiao Di Wang Ziping Ye Jingjing Ma Nana Tang Hongjie Zhang Elevated Levels of IL-27 Are Associated with Disease Activity in Patients with Crohn’s Disease
description	Immune disorders play an important role in the pathogenesis of Crohn’s disease (CD). Notably, the increased immune response of Th1 cells and related cytokines is associated with the onset of CD. IL-27 is a newly discovered IL-12-related cytokine, but its expression and clinical significance in CD patients are still controversial. This study is aimed at evaluating the serum levels of IL-27 in CD patients and analyzing their clinical significance. The results indicated that serum levels of IL-27 in CD patients were significantly higher than those in control subjects (median (interquartile range (IQR)): 110.0 (95.0, 145.0) vs. 85.0 (80.0, 95.0) pg/ml, P<0.001). Furthermore, the IL-27 levels significantly increased in CD patients at the active stage compared with CD patients in remission (CDR) (127.5 (100.0, 150.0) vs. 90 (80.0, 110.0) pg/ml, P<0.001). However, there was no difference in IL-27 levels between CDR and control subjects. The levels of IL-27 were positively correlated with Crohn’s disease activity index (CDAI), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), fecal calprotectin (FC), and Simple Endoscopic Score for Crohn’s Disease (SES-CD) and negatively correlated with hemoglobin (Hb) and serum albumin (ALB). IL-27 combined with CRP favored the prediction of CD activity (area under the curve (AUC): 0.88). Additionally, the proportions of Th17 and Th1 cells in peripheral blood were higher in CD patients than in control subjects. Active CD patients exhibited significantly higher proportions of Th17 and Th1 cells than those in remission. Moreover, correlation analysis indicated that the serum levels of IL-27 were positively associated with the frequency of Th17 cells in CD patients (r=0.519, P=0.013) but not associated with the frequency of Th1 cells in CD patients. IL-27 is positively associated with multiple inflammation indicators and may exert a proinflammatory profile by regulating Th17 cell differentiation in the development of Crohn’s disease. In the future, IL-27 combined with CRP is expected to become an important biological marker of CD activity.
format	article
author	Xiufang Cui Chunhua Jiao Di Wang Ziping Ye Jingjing Ma Nana Tang Hongjie Zhang
author_facet	Xiufang Cui Chunhua Jiao Di Wang Ziping Ye Jingjing Ma Nana Tang Hongjie Zhang
author_sort	Xiufang Cui
title	Elevated Levels of IL-27 Are Associated with Disease Activity in Patients with Crohn’s Disease
title_short	Elevated Levels of IL-27 Are Associated with Disease Activity in Patients with Crohn’s Disease
title_full	Elevated Levels of IL-27 Are Associated with Disease Activity in Patients with Crohn’s Disease
title_fullStr	Elevated Levels of IL-27 Are Associated with Disease Activity in Patients with Crohn’s Disease
title_full_unstemmed	Elevated Levels of IL-27 Are Associated with Disease Activity in Patients with Crohn’s Disease
title_sort	elevated levels of il-27 are associated with disease activity in patients with crohn’s disease
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/30bcd28a9d9148d9880e8bba1a15b7ab
work_keys_str_mv	AT xiufangcui elevatedlevelsofil27areassociatedwithdiseaseactivityinpatientswithcrohnsdisease AT chunhuajiao elevatedlevelsofil27areassociatedwithdiseaseactivityinpatientswithcrohnsdisease AT diwang elevatedlevelsofil27areassociatedwithdiseaseactivityinpatientswithcrohnsdisease AT zipingye elevatedlevelsofil27areassociatedwithdiseaseactivityinpatientswithcrohnsdisease AT jingjingma elevatedlevelsofil27areassociatedwithdiseaseactivityinpatientswithcrohnsdisease AT nanatang elevatedlevelsofil27areassociatedwithdiseaseactivityinpatientswithcrohnsdisease AT hongjiezhang elevatedlevelsofil27areassociatedwithdiseaseactivityinpatientswithcrohnsdisease
_version_	1718443078010798080

Elevated Levels of IL-27 Are Associated with Disease Activity in Patients with Crohn’s Disease

Ejemplares similares