Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing

Macrophages perform diverse functions during immune responses, but the molecular mechanisms by which physical properties of the tissue regulate macrophage behavior remain unknown. Here the authors find that Piezo1 is a mechanosensor of stiffness, and that its activity modulates macrophage polarizati...

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Autores principales:	Hamza Atcha, Amit Jairaman, Jesse R. Holt, Vijaykumar S. Meli, Raji R. Nagalla, Praveen Krishna Veerasubramanian, Kyle T. Brumm, Huy E. Lim, Shivashankar Othy, Michael D. Cahalan, Medha M. Pathak, Wendy F. Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/30c02e56c3ed471195876b3588e37e70
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spelling	oai:doaj.org-article:30c02e56c3ed471195876b3588e37e702021-12-02T18:24:49ZMechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing10.1038/s41467-021-23482-52041-1723https://doaj.org/article/30c02e56c3ed471195876b3588e37e702021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23482-5https://doaj.org/toc/2041-1723Macrophages perform diverse functions during immune responses, but the molecular mechanisms by which physical properties of the tissue regulate macrophage behavior remain unknown. Here the authors find that Piezo1 is a mechanosensor of stiffness, and that its activity modulates macrophage polarization responses.Hamza AtchaAmit JairamanJesse R. HoltVijaykumar S. MeliRaji R. NagallaPraveen Krishna VeerasubramanianKyle T. BrummHuy E. LimShivashankar OthyMichael D. CahalanMedha M. PathakWendy F. LiuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hamza Atcha Amit Jairaman Jesse R. Holt Vijaykumar S. Meli Raji R. Nagalla Praveen Krishna Veerasubramanian Kyle T. Brumm Huy E. Lim Shivashankar Othy Michael D. Cahalan Medha M. Pathak Wendy F. Liu Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing
description	Macrophages perform diverse functions during immune responses, but the molecular mechanisms by which physical properties of the tissue regulate macrophage behavior remain unknown. Here the authors find that Piezo1 is a mechanosensor of stiffness, and that its activity modulates macrophage polarization responses.
format	article
author	Hamza Atcha Amit Jairaman Jesse R. Holt Vijaykumar S. Meli Raji R. Nagalla Praveen Krishna Veerasubramanian Kyle T. Brumm Huy E. Lim Shivashankar Othy Michael D. Cahalan Medha M. Pathak Wendy F. Liu
author_facet	Hamza Atcha Amit Jairaman Jesse R. Holt Vijaykumar S. Meli Raji R. Nagalla Praveen Krishna Veerasubramanian Kyle T. Brumm Huy E. Lim Shivashankar Othy Michael D. Cahalan Medha M. Pathak Wendy F. Liu
author_sort	Hamza Atcha
title	Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing
title_short	Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing
title_full	Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing
title_fullStr	Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing
title_full_unstemmed	Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing
title_sort	mechanically activated ion channel piezo1 modulates macrophage polarization and stiffness sensing
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/30c02e56c3ed471195876b3588e37e70
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Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing

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