The U Shaped Relationship Between High-Density Lipoprotein Cholesterol and All-Cause or Cause-Specific Mortality in Adult Population
Yu-qing Huang,1 Xiao-cong Liu,1 Kenneth Lo,1,2 Lin Liu,1 Yu-ling Yu,1 Chao-lei Chen,1 Jia-yi Huang,1 Ying-qing Feng,1 Bin Zhang1 1Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, P...
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Dove Medical Press
2020
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oai:doaj.org-article:30c3018e6899469d808cc565718e1cfb2021-12-02T11:15:22ZThe U Shaped Relationship Between High-Density Lipoprotein Cholesterol and All-Cause or Cause-Specific Mortality in Adult Population1178-1998https://doaj.org/article/30c3018e6899469d808cc565718e1cfb2020-10-01T00:00:00Zhttps://www.dovepress.com/the-u-shaped-relationship-between-high-density-lipoprotein-cholesterol-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Yu-qing Huang,1 Xiao-cong Liu,1 Kenneth Lo,1,2 Lin Liu,1 Yu-ling Yu,1 Chao-lei Chen,1 Jia-yi Huang,1 Ying-qing Feng,1 Bin Zhang1 1Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, People’s Republic of China; 2Department of Epidemiology, Centre for Global Cardio-Metabolic Health, Brown University, Providence, RI, USACorrespondence: Ying-qing Feng; Bin ZhangDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, No. 106, Zhongshan Second Road, Yuexiu District, Guangzhou 510080, People’s Republic of ChinaTel/ Fax +86-20-83827812Email 651792209@qq.com; 3418989350@qq.comPurpose: The associations of high-density lipoprotein cholesterol (HDL-C) with mortality are still unclear. We explored the associations of HDL-C with all-cause and cause-specific mortality in an adult population.Methods: Deaths were classified into all-cause, cardiovascular, and cancer mortality. Survival curve, multivariate Cox regression, and subgroup analyses were conducted, and hazard ratio (HR) and 95% confidence interval (CI) were performed. We fitted Cox regression models for all-cause, cardiovascular, and cancer mortality to evaluate their associations with categories of HDL-C (≤ 30, 31– 40, 41– 50, 51– 60 [reference], 61– 70, > 70 mg/dL).Results: A total of 42,145 (20,415 (48.44%) males, mean age 47.12± 19.40 years) subjects were enrolled. At an average follow-up of 97.52± 54.03 months, all-cause, cardiovascular, and cancer mortality numbers were 5,061 (12.01), 1,081 (2.56%), and 1,061 (2.52%), respectively. When compared with the reference group (HDL-C: 51– 60 mg/dL), a U-shaped association was apparent for all-cause mortality, with elevated risk in participants with the lowest (≤ 30 mg/dL) (HR=1.33; 95% CI=1.14– 1.56) and highest (> 70 mg/dL) (HR=1.14; 95% CI=1.02– 1.27) HDL-C concentration. Associations for cardiovascular and cancer mortality were non-linear. An elevated risk for cancer mortality was observed in those with the highest HDL-C concentration (HR=1.06; 95% CI– 0.84– 1.34) compared with the reference group, although it was not statistically significant. The effect of HDL-C on mortality was adjusted by some traditional risk factors including age, gender, race, or comorbidities.Conclusion: A U-shaped association was observed between HDL-C and all-cause mortality among an adult population.Keywords: high-density lipoprotein cholesterol, mortality, all-cause mortality, cause-specific mortalityHuang YLiu XLo KLiu LYu YChen CHuang JFeng YZhang BDove Medical Pressarticlehigh density lipoprotein cholesterolmortalityall-cause mortalitycause-specific mortalityGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 15, Pp 1883-1896 (2020) |
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DOAJ |
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high density lipoprotein cholesterol mortality all-cause mortality cause-specific mortality Geriatrics RC952-954.6 |
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high density lipoprotein cholesterol mortality all-cause mortality cause-specific mortality Geriatrics RC952-954.6 Huang Y Liu X Lo K Liu L Yu Y Chen C Huang J Feng Y Zhang B The U Shaped Relationship Between High-Density Lipoprotein Cholesterol and All-Cause or Cause-Specific Mortality in Adult Population |
| description |
Yu-qing Huang,1 Xiao-cong Liu,1 Kenneth Lo,1,2 Lin Liu,1 Yu-ling Yu,1 Chao-lei Chen,1 Jia-yi Huang,1 Ying-qing Feng,1 Bin Zhang1 1Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, People’s Republic of China; 2Department of Epidemiology, Centre for Global Cardio-Metabolic Health, Brown University, Providence, RI, USACorrespondence: Ying-qing Feng; Bin ZhangDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, No. 106, Zhongshan Second Road, Yuexiu District, Guangzhou 510080, People’s Republic of ChinaTel/ Fax +86-20-83827812Email 651792209@qq.com; 3418989350@qq.comPurpose: The associations of high-density lipoprotein cholesterol (HDL-C) with mortality are still unclear. We explored the associations of HDL-C with all-cause and cause-specific mortality in an adult population.Methods: Deaths were classified into all-cause, cardiovascular, and cancer mortality. Survival curve, multivariate Cox regression, and subgroup analyses were conducted, and hazard ratio (HR) and 95% confidence interval (CI) were performed. We fitted Cox regression models for all-cause, cardiovascular, and cancer mortality to evaluate their associations with categories of HDL-C (≤ 30, 31– 40, 41– 50, 51– 60 [reference], 61– 70, > 70 mg/dL).Results: A total of 42,145 (20,415 (48.44%) males, mean age 47.12± 19.40 years) subjects were enrolled. At an average follow-up of 97.52± 54.03 months, all-cause, cardiovascular, and cancer mortality numbers were 5,061 (12.01), 1,081 (2.56%), and 1,061 (2.52%), respectively. When compared with the reference group (HDL-C: 51– 60 mg/dL), a U-shaped association was apparent for all-cause mortality, with elevated risk in participants with the lowest (≤ 30 mg/dL) (HR=1.33; 95% CI=1.14– 1.56) and highest (> 70 mg/dL) (HR=1.14; 95% CI=1.02– 1.27) HDL-C concentration. Associations for cardiovascular and cancer mortality were non-linear. An elevated risk for cancer mortality was observed in those with the highest HDL-C concentration (HR=1.06; 95% CI– 0.84– 1.34) compared with the reference group, although it was not statistically significant. The effect of HDL-C on mortality was adjusted by some traditional risk factors including age, gender, race, or comorbidities.Conclusion: A U-shaped association was observed between HDL-C and all-cause mortality among an adult population.Keywords: high-density lipoprotein cholesterol, mortality, all-cause mortality, cause-specific mortality |
| format |
article |
| author |
Huang Y Liu X Lo K Liu L Yu Y Chen C Huang J Feng Y Zhang B |
| author_facet |
Huang Y Liu X Lo K Liu L Yu Y Chen C Huang J Feng Y Zhang B |
| author_sort |
Huang Y |
| title |
The U Shaped Relationship Between High-Density Lipoprotein Cholesterol and All-Cause or Cause-Specific Mortality in Adult Population |
| title_short |
The U Shaped Relationship Between High-Density Lipoprotein Cholesterol and All-Cause or Cause-Specific Mortality in Adult Population |
| title_full |
The U Shaped Relationship Between High-Density Lipoprotein Cholesterol and All-Cause or Cause-Specific Mortality in Adult Population |
| title_fullStr |
The U Shaped Relationship Between High-Density Lipoprotein Cholesterol and All-Cause or Cause-Specific Mortality in Adult Population |
| title_full_unstemmed |
The U Shaped Relationship Between High-Density Lipoprotein Cholesterol and All-Cause or Cause-Specific Mortality in Adult Population |
| title_sort |
u shaped relationship between high-density lipoprotein cholesterol and all-cause or cause-specific mortality in adult population |
| publisher |
Dove Medical Press |
| publishDate |
2020 |
| url |
https://doaj.org/article/30c3018e6899469d808cc565718e1cfb |
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