Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer

The unfolded protein response (UPR) promotes cell survival in cancers with hyperactive ER stress response. Here the authors show that CARM1, an arginine methyltransferase, controls the IRE1α/XBP1 pathway of the UPR and the inhibition of this pathway can inhibit growth in CARM1 expressing ovarian can...

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Autores principales:	Jianhuang Lin, Heng Liu, Takeshi Fukumoto, Joseph Zundell, Qingqing Yan, Chih-Hang Anthony Tang, Shuai Wu, Wei Zhou, Dajiang Guo, Sergey Karakashev, Chih-Chi Andrew Hu, Kavitha Sarma, Andrew V. Kossenkov, Rugang Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/30c7f569e8f14f29b50078b914b06fde
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spelling	oai:doaj.org-article:30c7f569e8f14f29b50078b914b06fde2021-12-02T14:55:09ZTargeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer10.1038/s41467-021-25684-32041-1723https://doaj.org/article/30c7f569e8f14f29b50078b914b06fde2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25684-3https://doaj.org/toc/2041-1723The unfolded protein response (UPR) promotes cell survival in cancers with hyperactive ER stress response. Here the authors show that CARM1, an arginine methyltransferase, controls the IRE1α/XBP1 pathway of the UPR and the inhibition of this pathway can inhibit growth in CARM1 expressing ovarian cancers.Jianhuang LinHeng LiuTakeshi FukumotoJoseph ZundellQingqing YanChih-Hang Anthony TangShuai WuWei ZhouDajiang GuoSergey KarakashevChih-Chi Andrew HuKavitha SarmaAndrew V. KossenkovRugang ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jianhuang Lin Heng Liu Takeshi Fukumoto Joseph Zundell Qingqing Yan Chih-Hang Anthony Tang Shuai Wu Wei Zhou Dajiang Guo Sergey Karakashev Chih-Chi Andrew Hu Kavitha Sarma Andrew V. Kossenkov Rugang Zhang Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer
description	The unfolded protein response (UPR) promotes cell survival in cancers with hyperactive ER stress response. Here the authors show that CARM1, an arginine methyltransferase, controls the IRE1α/XBP1 pathway of the UPR and the inhibition of this pathway can inhibit growth in CARM1 expressing ovarian cancers.
format	article
author	Jianhuang Lin Heng Liu Takeshi Fukumoto Joseph Zundell Qingqing Yan Chih-Hang Anthony Tang Shuai Wu Wei Zhou Dajiang Guo Sergey Karakashev Chih-Chi Andrew Hu Kavitha Sarma Andrew V. Kossenkov Rugang Zhang
author_facet	Jianhuang Lin Heng Liu Takeshi Fukumoto Joseph Zundell Qingqing Yan Chih-Hang Anthony Tang Shuai Wu Wei Zhou Dajiang Guo Sergey Karakashev Chih-Chi Andrew Hu Kavitha Sarma Andrew V. Kossenkov Rugang Zhang
author_sort	Jianhuang Lin
title	Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer
title_short	Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer
title_full	Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer
title_fullStr	Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer
title_full_unstemmed	Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer
title_sort	targeting the ire1α/xbp1s pathway suppresses carm1-expressing ovarian cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/30c7f569e8f14f29b50078b914b06fde
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Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer

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