TRPM2 ion channels steer neutrophils towards a source of hydrogen peroxide

TRPM2 ion channels steer neutrophils towards a source of hydrogen peroxide

Abstract Neutrophils must navigate accurately towards pathogens in order to destroy invaders and thus defend our bodies against infection. Here we show that hydrogen peroxide, a potent neutrophil chemoattractant, guides chemotaxis by activating calcium-permeable TRPM2 ion channels and generating an...

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Autores principales: Hassan Morad, Suaib Luqman, Chun-Hsiang Tan, Victoria Swann, Peter A. McNaughton
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/30cdafce157949a5a2be906a5b87c6f5
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