Remodeling of the tumor microenvironment via disrupting Blimp1+ effector Treg activity augments response to anti-PD-1 blockade

Abstract Background Accumulation of Foxp3+ regulatory T (Treg) cells in the tumor often represents an important mechanism for cancer immune evasion and a critical barrier to anti-tumor immunity and immunotherapy. Many tumor-infiltrating Treg cells display an activated phenotype and express the trans...

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Autores principales:	Michael L. Dixon, Lin Luo, Sadashib Ghosh, Jeffrey M. Grimes, Jonathan D. Leavenworth, Jianmei W. Leavenworth
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Anti-tumor immunity Humoral antibody response IgE Effector regulatory T-cells Follicular regulatory T-cells Treg lineage stability Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/30ce81d646da475cb6af87c87c5a8680
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Remodeling of the tumor microenvironment via disrupting Blimp1+ effector Treg activity augments response to anti-PD-1 blockade

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