Effect of insulin treatment on pulsatility ratio and resistance index of the retinal artery in patients with type 2 diabetes.

This study aimed to evaluate whether long-term insulin treatment is associated with abnormalities in retinal circulation in type 2 diabetic patients. We evaluated 19 eyes of nondiabetic individuals and 68 eyes of type 2 diabetic patients. The eyes of diabetic patients were classified into two groups...

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Autores principales:	Tsuneaki Omae, Youngseok Song, Takafumi Yoshioka, Tomofumi Tani, Akitoshi Yoshida
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/30d3bb45c53c430d80ad3e784602871f
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spelling	oai:doaj.org-article:30d3bb45c53c430d80ad3e784602871f2021-12-02T20:06:47ZEffect of insulin treatment on pulsatility ratio and resistance index of the retinal artery in patients with type 2 diabetes.1932-620310.1371/journal.pone.0254980https://doaj.org/article/30d3bb45c53c430d80ad3e784602871f2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254980https://doaj.org/toc/1932-6203This study aimed to evaluate whether long-term insulin treatment is associated with abnormalities in retinal circulation in type 2 diabetic patients. We evaluated 19 eyes of nondiabetic individuals and 68 eyes of type 2 diabetic patients. The eyes of diabetic patients were classified into two groups according to the presence or absence of long-term insulin therapy. We used a Doppler optical coherence tomography flowmeter to measure diameter, velocity, and blood flow in the major temporal retinal artery. The pulsatility ratio (PR) and resistance index (RI), indices of vascular rigidity, were calculated from the blood velocity profile. PR and RI were significantly elevated in type 2 diabetic patients compared with nondiabetic subjects (P < 0.05). In type 2 diabetes patients, PR and RI were significantly higher in patients receiving long-term insulin treatment than in those without (P < 0.01). There was a significant difference in velocity (P < 0.05), but not diameter and blood flow, between nondiabetic subjects and type 2 diabetes patients. No significant difference in diameter, velocity, or blood flow was observed between the groups with and without long-term insulin treatment. Long-term insulin treatment can affect PR and RI, which might be associated with vascular rigidity of the retinal artery in patients with type 2 diabetes.Tsuneaki OmaeYoungseok SongTakafumi YoshiokaTomofumi TaniAkitoshi YoshidaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254980 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tsuneaki Omae Youngseok Song Takafumi Yoshioka Tomofumi Tani Akitoshi Yoshida Effect of insulin treatment on pulsatility ratio and resistance index of the retinal artery in patients with type 2 diabetes.
description	This study aimed to evaluate whether long-term insulin treatment is associated with abnormalities in retinal circulation in type 2 diabetic patients. We evaluated 19 eyes of nondiabetic individuals and 68 eyes of type 2 diabetic patients. The eyes of diabetic patients were classified into two groups according to the presence or absence of long-term insulin therapy. We used a Doppler optical coherence tomography flowmeter to measure diameter, velocity, and blood flow in the major temporal retinal artery. The pulsatility ratio (PR) and resistance index (RI), indices of vascular rigidity, were calculated from the blood velocity profile. PR and RI were significantly elevated in type 2 diabetic patients compared with nondiabetic subjects (P < 0.05). In type 2 diabetes patients, PR and RI were significantly higher in patients receiving long-term insulin treatment than in those without (P < 0.01). There was a significant difference in velocity (P < 0.05), but not diameter and blood flow, between nondiabetic subjects and type 2 diabetes patients. No significant difference in diameter, velocity, or blood flow was observed between the groups with and without long-term insulin treatment. Long-term insulin treatment can affect PR and RI, which might be associated with vascular rigidity of the retinal artery in patients with type 2 diabetes.
format	article
author	Tsuneaki Omae Youngseok Song Takafumi Yoshioka Tomofumi Tani Akitoshi Yoshida
author_facet	Tsuneaki Omae Youngseok Song Takafumi Yoshioka Tomofumi Tani Akitoshi Yoshida
author_sort	Tsuneaki Omae
title	Effect of insulin treatment on pulsatility ratio and resistance index of the retinal artery in patients with type 2 diabetes.
title_short	Effect of insulin treatment on pulsatility ratio and resistance index of the retinal artery in patients with type 2 diabetes.
title_full	Effect of insulin treatment on pulsatility ratio and resistance index of the retinal artery in patients with type 2 diabetes.
title_fullStr	Effect of insulin treatment on pulsatility ratio and resistance index of the retinal artery in patients with type 2 diabetes.
title_full_unstemmed	Effect of insulin treatment on pulsatility ratio and resistance index of the retinal artery in patients with type 2 diabetes.
title_sort	effect of insulin treatment on pulsatility ratio and resistance index of the retinal artery in patients with type 2 diabetes.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/30d3bb45c53c430d80ad3e784602871f
work_keys_str_mv	AT tsuneakiomae effectofinsulintreatmentonpulsatilityratioandresistanceindexoftheretinalarteryinpatientswithtype2diabetes AT youngseoksong effectofinsulintreatmentonpulsatilityratioandresistanceindexoftheretinalarteryinpatientswithtype2diabetes AT takafumiyoshioka effectofinsulintreatmentonpulsatilityratioandresistanceindexoftheretinalarteryinpatientswithtype2diabetes AT tomofumitani effectofinsulintreatmentonpulsatilityratioandresistanceindexoftheretinalarteryinpatientswithtype2diabetes AT akitoshiyoshida effectofinsulintreatmentonpulsatilityratioandresistanceindexoftheretinalarteryinpatientswithtype2diabetes
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Effect of insulin treatment on pulsatility ratio and resistance index of the retinal artery in patients with type 2 diabetes.

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