Neural basis of self-initiative in relation to apathy in a student sample

Abstract Human behaviour can be externally driven, e.g. catching a falling glass, or self-initiated and goal-directed, e.g. drinking a cup of coffee when one deems it is time for a break. Apathy refers to a reduction of self-initiated goal-directed or motivated behaviour, frequently present in neuro...

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Autores principales:	Claire Kos, Nicky G. Klaasen, Jan-Bernard C. Marsman, Esther M. Opmeer, Henderikus Knegtering, André Aleman, Marie-José van Tol
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/30d5433d2cc747d08fe10950d02116a0
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spelling	oai:doaj.org-article:30d5433d2cc747d08fe10950d02116a02021-12-02T11:52:16ZNeural basis of self-initiative in relation to apathy in a student sample10.1038/s41598-017-03564-52045-2322https://doaj.org/article/30d5433d2cc747d08fe10950d02116a02017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03564-5https://doaj.org/toc/2045-2322Abstract Human behaviour can be externally driven, e.g. catching a falling glass, or self-initiated and goal-directed, e.g. drinking a cup of coffee when one deems it is time for a break. Apathy refers to a reduction of self-initiated goal-directed or motivated behaviour, frequently present in neurological and psychiatric disorders. The amount of undertaken goal-directed behaviour varies considerably in clinical as well as healthy populations. In the present study, we investigated behavioural and neural correlates of self-initiated action in a student sample (N = 39) with minimal to high levels of apathy. We replicated activation of fronto-parieto-striatal regions during self-initiation. The neural correlates of self-initiated action did not explain varying levels of apathy in our sample, neither when mass-univariate analysis was used, nor when multivariate patterns of brain activation were considered. Other hypotheses, e.g. regarding a putative role of deficits in reward anticipation, effort expenditure or executive difficulties, deserve investigation in future studies.Claire KosNicky G. KlaasenJan-Bernard C. MarsmanEsther M. OpmeerHenderikus KnegteringAndré AlemanMarie-José van TolNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Claire Kos Nicky G. Klaasen Jan-Bernard C. Marsman Esther M. Opmeer Henderikus Knegtering André Aleman Marie-José van Tol Neural basis of self-initiative in relation to apathy in a student sample
description	Abstract Human behaviour can be externally driven, e.g. catching a falling glass, or self-initiated and goal-directed, e.g. drinking a cup of coffee when one deems it is time for a break. Apathy refers to a reduction of self-initiated goal-directed or motivated behaviour, frequently present in neurological and psychiatric disorders. The amount of undertaken goal-directed behaviour varies considerably in clinical as well as healthy populations. In the present study, we investigated behavioural and neural correlates of self-initiated action in a student sample (N = 39) with minimal to high levels of apathy. We replicated activation of fronto-parieto-striatal regions during self-initiation. The neural correlates of self-initiated action did not explain varying levels of apathy in our sample, neither when mass-univariate analysis was used, nor when multivariate patterns of brain activation were considered. Other hypotheses, e.g. regarding a putative role of deficits in reward anticipation, effort expenditure or executive difficulties, deserve investigation in future studies.
format	article
author	Claire Kos Nicky G. Klaasen Jan-Bernard C. Marsman Esther M. Opmeer Henderikus Knegtering André Aleman Marie-José van Tol
author_facet	Claire Kos Nicky G. Klaasen Jan-Bernard C. Marsman Esther M. Opmeer Henderikus Knegtering André Aleman Marie-José van Tol
author_sort	Claire Kos
title	Neural basis of self-initiative in relation to apathy in a student sample
title_short	Neural basis of self-initiative in relation to apathy in a student sample
title_full	Neural basis of self-initiative in relation to apathy in a student sample
title_fullStr	Neural basis of self-initiative in relation to apathy in a student sample
title_full_unstemmed	Neural basis of self-initiative in relation to apathy in a student sample
title_sort	neural basis of self-initiative in relation to apathy in a student sample
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/30d5433d2cc747d08fe10950d02116a0
work_keys_str_mv	AT clairekos neuralbasisofselfinitiativeinrelationtoapathyinastudentsample AT nickygklaasen neuralbasisofselfinitiativeinrelationtoapathyinastudentsample AT janbernardcmarsman neuralbasisofselfinitiativeinrelationtoapathyinastudentsample AT esthermopmeer neuralbasisofselfinitiativeinrelationtoapathyinastudentsample AT henderikusknegtering neuralbasisofselfinitiativeinrelationtoapathyinastudentsample AT andrealeman neuralbasisofselfinitiativeinrelationtoapathyinastudentsample AT mariejosevantol neuralbasisofselfinitiativeinrelationtoapathyinastudentsample
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Neural basis of self-initiative in relation to apathy in a student sample

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