The macrophages in rheumatic diseases

Antonella Laria, Alfredomaria Lurati , Mariagrazia Marrazza , Daniela Mazzocchi, Katia Angela Re, Magda Scarpellini Rheumatology Unit, Fornaroli Hospital, Magenta, Italy Abstract: Macrophages belong to the innate immune system giving us protection against pathogens. However it is known that they are...

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Autores principales:	Laria A, Lurati A, Marrazza M, Mazzocchi D, Re KA, Scarpellini M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	MACROPHAGE RHEUMATIC DISEASES Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/30d58c80276742b2a41e60e0034b9ec2
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spelling	oai:doaj.org-article:30d58c80276742b2a41e60e0034b9ec22021-12-02T02:58:05ZThe macrophages in rheumatic diseases1178-7031https://doaj.org/article/30d58c80276742b2a41e60e0034b9ec22016-02-01T00:00:00Zhttps://www.dovepress.com/the-macrophages-in-rheumatic-diseases-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Antonella Laria, Alfredomaria Lurati , Mariagrazia Marrazza , Daniela Mazzocchi, Katia Angela Re, Magda Scarpellini Rheumatology Unit, Fornaroli Hospital, Magenta, Italy Abstract: Macrophages belong to the innate immune system giving us protection against pathogens. However it is known that they are also involved in rheumatic diseases. Activated macrophages have two different phenotypes related to different stimuli: M1 (classically activated) and M2 (alternatively activated). M1 macrophages release high levels of pro-inflammatory cytokines, reactive nitrogen and oxygen intermediates killing microorganisms and tumor cells; while M2 macrophages are involved in resolution of inflammation through phagocytosis of apoptotic neutrophils, reduced production of pro-inflammatory cytokines, and increased synthesis of mediators important in tissue remodeling, angiogenesis, and wound repair. The role of macrophages in the different rheumatic diseases is different according to their M1/M2 macrophages phenotype. Keywords: macrophage, rheumatic diseasesLaria ALurati AMarrazza MMazzocchi DRe KAScarpellini MDove Medical PressarticleMACROPHAGERHEUMATIC DISEASESPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol 2016, Iss Issue 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	MACROPHAGE RHEUMATIC DISEASES Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	MACROPHAGE RHEUMATIC DISEASES Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Laria A Lurati A Marrazza M Mazzocchi D Re KA Scarpellini M The macrophages in rheumatic diseases
description	Antonella Laria, Alfredomaria Lurati , Mariagrazia Marrazza , Daniela Mazzocchi, Katia Angela Re, Magda Scarpellini Rheumatology Unit, Fornaroli Hospital, Magenta, Italy Abstract: Macrophages belong to the innate immune system giving us protection against pathogens. However it is known that they are also involved in rheumatic diseases. Activated macrophages have two different phenotypes related to different stimuli: M1 (classically activated) and M2 (alternatively activated). M1 macrophages release high levels of pro-inflammatory cytokines, reactive nitrogen and oxygen intermediates killing microorganisms and tumor cells; while M2 macrophages are involved in resolution of inflammation through phagocytosis of apoptotic neutrophils, reduced production of pro-inflammatory cytokines, and increased synthesis of mediators important in tissue remodeling, angiogenesis, and wound repair. The role of macrophages in the different rheumatic diseases is different according to their M1/M2 macrophages phenotype. Keywords: macrophage, rheumatic diseases
format	article
author	Laria A Lurati A Marrazza M Mazzocchi D Re KA Scarpellini M
author_facet	Laria A Lurati A Marrazza M Mazzocchi D Re KA Scarpellini M
author_sort	Laria A
title	The macrophages in rheumatic diseases
title_short	The macrophages in rheumatic diseases
title_full	The macrophages in rheumatic diseases
title_fullStr	The macrophages in rheumatic diseases
title_full_unstemmed	The macrophages in rheumatic diseases
title_sort	macrophages in rheumatic diseases
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/30d58c80276742b2a41e60e0034b9ec2
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The macrophages in rheumatic diseases

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