Altered Gabab Receptor Thermoregulatory Function in Rats with Diet-Induced Obesity

GABAB receptors are G-protein-coupled receptors, playing a very important role in the regulation of many physiological processes. The GABAB signaling pathway could modulate neurotransmission processes at the level of the preoptic area in the anterior hypothalamus, which is thought to function as the...

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Autores principales:	Hristov M., Yakimova Kr.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2019
Materias:	gabab agonist and antagonist thermoregulation obesity Medicine R
Acceso en línea:	https://doaj.org/article/30dcd54b7db3433293f9ec5955e47537
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spelling	oai:doaj.org-article:30dcd54b7db3433293f9ec5955e475372021-12-02T19:05:13ZAltered Gabab Receptor Thermoregulatory Function in Rats with Diet-Induced Obesity0324-175010.2478/amb-2019-0013https://doaj.org/article/30dcd54b7db3433293f9ec5955e475372019-05-01T00:00:00Zhttps://doi.org/10.2478/amb-2019-0013https://doaj.org/toc/0324-1750GABAB receptors are G-protein-coupled receptors, playing a very important role in the regulation of many physiological processes. The GABAB signaling pathway could modulate neurotransmission processes at the level of the preoptic area in the anterior hypothalamus, which is thought to function as the thermoregulatory center. The present study was performed to investigate the effects of GABAB agonists and antagonists on core body temperature of rats with normal weight and diet-induced obesity. The results showed that systemic administration of the GABAB antagonist CGP35348 induced significant hyper-thermia in rats with normal weight, whereas the GABAB agonist baclofen led to a decrease in body temperature. The effects of baclofen and CGP35348 on body temperature were less pronounced in rats with diet-induced obesity compared with those with normal weight. Presently it remains unclear how obesity affects the GABAB receptor function at the level of the central thermoregulatory system.Hristov M.Yakimova Kr.Sciendoarticlegabab agonist and antagonistthermoregulationobesityMedicineRENActa Medica Bulgarica, Vol 46, Iss 2, Pp 21-24 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	gabab agonist and antagonist thermoregulation obesity Medicine R
spellingShingle	gabab agonist and antagonist thermoregulation obesity Medicine R Hristov M. Yakimova Kr. Altered Gabab Receptor Thermoregulatory Function in Rats with Diet-Induced Obesity
description	GABAB receptors are G-protein-coupled receptors, playing a very important role in the regulation of many physiological processes. The GABAB signaling pathway could modulate neurotransmission processes at the level of the preoptic area in the anterior hypothalamus, which is thought to function as the thermoregulatory center. The present study was performed to investigate the effects of GABAB agonists and antagonists on core body temperature of rats with normal weight and diet-induced obesity. The results showed that systemic administration of the GABAB antagonist CGP35348 induced significant hyper-thermia in rats with normal weight, whereas the GABAB agonist baclofen led to a decrease in body temperature. The effects of baclofen and CGP35348 on body temperature were less pronounced in rats with diet-induced obesity compared with those with normal weight. Presently it remains unclear how obesity affects the GABAB receptor function at the level of the central thermoregulatory system.
format	article
author	Hristov M. Yakimova Kr.
author_facet	Hristov M. Yakimova Kr.
author_sort	Hristov M.
title	Altered Gabab Receptor Thermoregulatory Function in Rats with Diet-Induced Obesity
title_short	Altered Gabab Receptor Thermoregulatory Function in Rats with Diet-Induced Obesity
title_full	Altered Gabab Receptor Thermoregulatory Function in Rats with Diet-Induced Obesity
title_fullStr	Altered Gabab Receptor Thermoregulatory Function in Rats with Diet-Induced Obesity
title_full_unstemmed	Altered Gabab Receptor Thermoregulatory Function in Rats with Diet-Induced Obesity
title_sort	altered gabab receptor thermoregulatory function in rats with diet-induced obesity
publisher	Sciendo
publishDate	2019
url	https://doaj.org/article/30dcd54b7db3433293f9ec5955e47537
work_keys_str_mv	AT hristovm alteredgababreceptorthermoregulatoryfunctioninratswithdietinducedobesity AT yakimovakr alteredgababreceptorthermoregulatoryfunctioninratswithdietinducedobesity
_version_	1718377200156147712

Altered Gabab Receptor Thermoregulatory Function in Rats with Diet-Induced Obesity

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