Familial Associations of Colorectal Cancer with Other Cancers

Abstract Colorectal cancer (CRC) has a strong familial component which extends to discordant cancers (ie non-CRC tumors). This is best seen in cancer syndromes such as hereditary non-polyposis colorectal cancer (HNPCC) which predisposes to several tumor types. Population-based family studies have al...

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Autores principales:	Hongyao Yu, Akseli Hemminki, Kristina Sundquist, Kari Hemminki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/30de064cf1a64caf966377e9c3eed9f7
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spelling	oai:doaj.org-article:30de064cf1a64caf966377e9c3eed9f72021-12-02T15:06:02ZFamilial Associations of Colorectal Cancer with Other Cancers10.1038/s41598-017-05732-z2045-2322https://doaj.org/article/30de064cf1a64caf966377e9c3eed9f72017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05732-zhttps://doaj.org/toc/2045-2322Abstract Colorectal cancer (CRC) has a strong familial component which extends to discordant cancers (ie non-CRC tumors). This is best seen in cancer syndromes such as hereditary non-polyposis colorectal cancer (HNPCC) which predisposes to several tumor types. Population-based family studies have also found discordant associations for CRC but they have included cancers which manifest in HNPCC, and there is no convincing evidence of discordant associations beyond the known syndromes. We address familial associations of non-CRC tumors with CRC using the resources of the Swedish Family-Cancer Database and applying a powerful approach of assessing familial relative risks in families of increasing numbers of patients with discordant cancers. Among 1.8 million cancer patients and over 200,000 CRC cases consistent familial associations of CRC was observed for several HNPCC related cancers. However, for small intestinal, pancreatic and nervous system cancers RRs remained essentially unchanged when potential HNPCC families were excluded, suggesting involvement of genes not related to HNPCC. Two independent associations of CRC were found for melanoma, thyroid and eye cancers and these appeared not to be related to known syndromes. A number of other cancers associated with CRC in single analyses and independent studies are required to assess the relevance of such findings.Hongyao YuAkseli HemminkiKristina SundquistKari HemminkiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-5 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hongyao Yu Akseli Hemminki Kristina Sundquist Kari Hemminki Familial Associations of Colorectal Cancer with Other Cancers
description	Abstract Colorectal cancer (CRC) has a strong familial component which extends to discordant cancers (ie non-CRC tumors). This is best seen in cancer syndromes such as hereditary non-polyposis colorectal cancer (HNPCC) which predisposes to several tumor types. Population-based family studies have also found discordant associations for CRC but they have included cancers which manifest in HNPCC, and there is no convincing evidence of discordant associations beyond the known syndromes. We address familial associations of non-CRC tumors with CRC using the resources of the Swedish Family-Cancer Database and applying a powerful approach of assessing familial relative risks in families of increasing numbers of patients with discordant cancers. Among 1.8 million cancer patients and over 200,000 CRC cases consistent familial associations of CRC was observed for several HNPCC related cancers. However, for small intestinal, pancreatic and nervous system cancers RRs remained essentially unchanged when potential HNPCC families were excluded, suggesting involvement of genes not related to HNPCC. Two independent associations of CRC were found for melanoma, thyroid and eye cancers and these appeared not to be related to known syndromes. A number of other cancers associated with CRC in single analyses and independent studies are required to assess the relevance of such findings.
format	article
author	Hongyao Yu Akseli Hemminki Kristina Sundquist Kari Hemminki
author_facet	Hongyao Yu Akseli Hemminki Kristina Sundquist Kari Hemminki
author_sort	Hongyao Yu
title	Familial Associations of Colorectal Cancer with Other Cancers
title_short	Familial Associations of Colorectal Cancer with Other Cancers
title_full	Familial Associations of Colorectal Cancer with Other Cancers
title_fullStr	Familial Associations of Colorectal Cancer with Other Cancers
title_full_unstemmed	Familial Associations of Colorectal Cancer with Other Cancers
title_sort	familial associations of colorectal cancer with other cancers
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/30de064cf1a64caf966377e9c3eed9f7
work_keys_str_mv	AT hongyaoyu familialassociationsofcolorectalcancerwithothercancers AT akselihemminki familialassociationsofcolorectalcancerwithothercancers AT kristinasundquist familialassociationsofcolorectalcancerwithothercancers AT karihemminki familialassociationsofcolorectalcancerwithothercancers
_version_	1718388571414462464

Familial Associations of Colorectal Cancer with Other Cancers

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