The Emerging Role of Metabolism in Brain-Heart Axis: New Challenge for the Therapy and Prevention of Alzheimer Disease. May Thioredoxin Interacting Protein (TXNIP) Play a Role?

Alzheimer disease (AD) is the most frequent cause of dementia and up to now there is not an effective therapy to cure AD. In addition, AD onset occurs decades before the diagnosis, affecting the possibility to set up appropriate therapeutic strategies. For this reason, it is necessary to investigate...

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Autores principales:	Lorena Perrone, Mariarosaria Valente
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	brain-heart axis metabolism cardiovascular diseases TXNIP microbiota Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/30dead55902442958497c4b8ac365cba
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spelling	oai:doaj.org-article:30dead55902442958497c4b8ac365cba2021-11-25T16:53:24ZThe Emerging Role of Metabolism in Brain-Heart Axis: New Challenge for the Therapy and Prevention of Alzheimer Disease. May Thioredoxin Interacting Protein (TXNIP) Play a Role?10.3390/biom111116522218-273Xhttps://doaj.org/article/30dead55902442958497c4b8ac365cba2021-11-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1652https://doaj.org/toc/2218-273XAlzheimer disease (AD) is the most frequent cause of dementia and up to now there is not an effective therapy to cure AD. In addition, AD onset occurs decades before the diagnosis, affecting the possibility to set up appropriate therapeutic strategies. For this reason, it is necessary to investigate the effects of risk factors, such as cardiovascular diseases, in promoting AD. AD shows not only brain dysfunction, but also alterations in peripheral tissues/organs. Indeed, it exists a reciprocal connection between brain and heart, where cardiovascular alterations participate to AD as well as AD seem to promote cardiovascular dysfunction. In addition, metabolic dysfunction promotes both cardiovascular diseases and AD. In this review, we summarize the pathways involved in the regulation of the brain-heart axis and the effect of metabolism on these pathways. We also present the studies showing the role of the gut microbiota on the brain-heart axis. Herein, we propose recent evidences of the function of Thioredoxin Interacting protein (TXNIP) in mediating the role of metabolism on the brain-heart axis. TXNIP is a key regulator of metabolism at both cellular and body level and it exerts also a pathological function in several cardiovascular diseases as well as in AD.Lorena PerroneMariarosaria ValenteMDPI AGarticlebrain-heart axismetabolismcardiovascular diseasesTXNIPmicrobiotaMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1652, p 1652 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	brain-heart axis metabolism cardiovascular diseases TXNIP microbiota Microbiology QR1-502
spellingShingle	brain-heart axis metabolism cardiovascular diseases TXNIP microbiota Microbiology QR1-502 Lorena Perrone Mariarosaria Valente The Emerging Role of Metabolism in Brain-Heart Axis: New Challenge for the Therapy and Prevention of Alzheimer Disease. May Thioredoxin Interacting Protein (TXNIP) Play a Role?
description	Alzheimer disease (AD) is the most frequent cause of dementia and up to now there is not an effective therapy to cure AD. In addition, AD onset occurs decades before the diagnosis, affecting the possibility to set up appropriate therapeutic strategies. For this reason, it is necessary to investigate the effects of risk factors, such as cardiovascular diseases, in promoting AD. AD shows not only brain dysfunction, but also alterations in peripheral tissues/organs. Indeed, it exists a reciprocal connection between brain and heart, where cardiovascular alterations participate to AD as well as AD seem to promote cardiovascular dysfunction. In addition, metabolic dysfunction promotes both cardiovascular diseases and AD. In this review, we summarize the pathways involved in the regulation of the brain-heart axis and the effect of metabolism on these pathways. We also present the studies showing the role of the gut microbiota on the brain-heart axis. Herein, we propose recent evidences of the function of Thioredoxin Interacting protein (TXNIP) in mediating the role of metabolism on the brain-heart axis. TXNIP is a key regulator of metabolism at both cellular and body level and it exerts also a pathological function in several cardiovascular diseases as well as in AD.
format	article
author	Lorena Perrone Mariarosaria Valente
author_facet	Lorena Perrone Mariarosaria Valente
author_sort	Lorena Perrone
title	The Emerging Role of Metabolism in Brain-Heart Axis: New Challenge for the Therapy and Prevention of Alzheimer Disease. May Thioredoxin Interacting Protein (TXNIP) Play a Role?
title_short	The Emerging Role of Metabolism in Brain-Heart Axis: New Challenge for the Therapy and Prevention of Alzheimer Disease. May Thioredoxin Interacting Protein (TXNIP) Play a Role?
title_full	The Emerging Role of Metabolism in Brain-Heart Axis: New Challenge for the Therapy and Prevention of Alzheimer Disease. May Thioredoxin Interacting Protein (TXNIP) Play a Role?
title_fullStr	The Emerging Role of Metabolism in Brain-Heart Axis: New Challenge for the Therapy and Prevention of Alzheimer Disease. May Thioredoxin Interacting Protein (TXNIP) Play a Role?
title_full_unstemmed	The Emerging Role of Metabolism in Brain-Heart Axis: New Challenge for the Therapy and Prevention of Alzheimer Disease. May Thioredoxin Interacting Protein (TXNIP) Play a Role?
title_sort	emerging role of metabolism in brain-heart axis: new challenge for the therapy and prevention of alzheimer disease. may thioredoxin interacting protein (txnip) play a role?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/30dead55902442958497c4b8ac365cba
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The Emerging Role of Metabolism in Brain-Heart Axis: New Challenge for the Therapy and Prevention of Alzheimer Disease. May Thioredoxin Interacting Protein (TXNIP) Play a Role?

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