Lipid Signaling Modulates the Response to Fumonisin Contamination and Its Source, Fusarium verticillioides, in Maize

Fumonisin-contaminated maize (Zea mays L.) products are a major health concern because of their toxic effects in humans and animals. Breeding maize for increased mycotoxin resistance is one of the key sustainable strategies for mitigating the effects of fumonisin contamination. Recent studies sugges...

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Autores principales:	Laura Righetti, Chiara Dall’Asta, Luigi Lucini, Paola Battilani
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	fumonisins metabolomics lipidomics oxylipins mycotoxins Plant culture SB1-1110
Acceso en línea:	https://doaj.org/article/30e3e27d95344b34beb4f6e433000f82
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spelling	oai:doaj.org-article:30e3e27d95344b34beb4f6e433000f822021-11-08T06:37:14ZLipid Signaling Modulates the Response to Fumonisin Contamination and Its Source, Fusarium verticillioides, in Maize1664-462X10.3389/fpls.2021.701680https://doaj.org/article/30e3e27d95344b34beb4f6e433000f822021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpls.2021.701680/fullhttps://doaj.org/toc/1664-462XFumonisin-contaminated maize (Zea mays L.) products are a major health concern because of their toxic effects in humans and animals. Breeding maize for increased mycotoxin resistance is one of the key sustainable strategies for mitigating the effects of fumonisin contamination. Recent studies suggest a link between fumonisin accumulation and plant lipid and oxylipin profiles. However, the data collected so far do not reveal a cause-and-effect relationship. In this study, to decipher the multifactorial nature of mycotoxin resistance and plant–pathogen interaction mechanisms, we examined the oxylipin and complex lipid profiles of two maize hybrids (H21 and H22, the latter showing significantly lower FBs content) grown in the open field in two locations over 3years. Untargeted ultra-high performance liquid chromatography coupled with quadrupole-time-of-flight (UHPLC-Q-TOF), together with chemometrics analysis, successfully distinguished between the two hybrids as having low- and high-level fumonisin contamination. Considering that H21 and H22 were exposed to the same environmental factors, the higher activation of lipid signaling systems in H22 suggests that other routes are enabled in the less susceptible hybrids to limit fumonisin B (FB) accumulation. Our results highlighted the crucial role played by oxylipin and sphingolipid signaling in modulating the complex maize response to F. verticillioides infection. Overall, our results returned a global view on the changes in lipid metabolites related to fumonisin accumulation under open field conditions, and revealed a strong activation of the lipid signaling cascade in maize in the presence of FB1.Laura RighettiChiara Dall’AstaLuigi LuciniPaola BattilaniFrontiers Media S.A.articlefumonisinsmetabolomicslipidomicsoxylipinsmycotoxinsPlant cultureSB1-1110ENFrontiers in Plant Science, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fumonisins metabolomics lipidomics oxylipins mycotoxins Plant culture SB1-1110
spellingShingle	fumonisins metabolomics lipidomics oxylipins mycotoxins Plant culture SB1-1110 Laura Righetti Chiara Dall’Asta Luigi Lucini Paola Battilani Lipid Signaling Modulates the Response to Fumonisin Contamination and Its Source, Fusarium verticillioides, in Maize
description	Fumonisin-contaminated maize (Zea mays L.) products are a major health concern because of their toxic effects in humans and animals. Breeding maize for increased mycotoxin resistance is one of the key sustainable strategies for mitigating the effects of fumonisin contamination. Recent studies suggest a link between fumonisin accumulation and plant lipid and oxylipin profiles. However, the data collected so far do not reveal a cause-and-effect relationship. In this study, to decipher the multifactorial nature of mycotoxin resistance and plant–pathogen interaction mechanisms, we examined the oxylipin and complex lipid profiles of two maize hybrids (H21 and H22, the latter showing significantly lower FBs content) grown in the open field in two locations over 3years. Untargeted ultra-high performance liquid chromatography coupled with quadrupole-time-of-flight (UHPLC-Q-TOF), together with chemometrics analysis, successfully distinguished between the two hybrids as having low- and high-level fumonisin contamination. Considering that H21 and H22 were exposed to the same environmental factors, the higher activation of lipid signaling systems in H22 suggests that other routes are enabled in the less susceptible hybrids to limit fumonisin B (FB) accumulation. Our results highlighted the crucial role played by oxylipin and sphingolipid signaling in modulating the complex maize response to F. verticillioides infection. Overall, our results returned a global view on the changes in lipid metabolites related to fumonisin accumulation under open field conditions, and revealed a strong activation of the lipid signaling cascade in maize in the presence of FB1.
format	article
author	Laura Righetti Chiara Dall’Asta Luigi Lucini Paola Battilani
author_facet	Laura Righetti Chiara Dall’Asta Luigi Lucini Paola Battilani
author_sort	Laura Righetti
title	Lipid Signaling Modulates the Response to Fumonisin Contamination and Its Source, Fusarium verticillioides, in Maize
title_short	Lipid Signaling Modulates the Response to Fumonisin Contamination and Its Source, Fusarium verticillioides, in Maize
title_full	Lipid Signaling Modulates the Response to Fumonisin Contamination and Its Source, Fusarium verticillioides, in Maize
title_fullStr	Lipid Signaling Modulates the Response to Fumonisin Contamination and Its Source, Fusarium verticillioides, in Maize
title_full_unstemmed	Lipid Signaling Modulates the Response to Fumonisin Contamination and Its Source, Fusarium verticillioides, in Maize
title_sort	lipid signaling modulates the response to fumonisin contamination and its source, fusarium verticillioides, in maize
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/30e3e27d95344b34beb4f6e433000f82
work_keys_str_mv	AT laurarighetti lipidsignalingmodulatestheresponsetofumonisincontaminationanditssourcefusariumverticillioidesinmaize AT chiaradallasta lipidsignalingmodulatestheresponsetofumonisincontaminationanditssourcefusariumverticillioidesinmaize AT luigilucini lipidsignalingmodulatestheresponsetofumonisincontaminationanditssourcefusariumverticillioidesinmaize AT paolabattilani lipidsignalingmodulatestheresponsetofumonisincontaminationanditssourcefusariumverticillioidesinmaize
_version_	1718442890940645376

Lipid Signaling Modulates the Response to Fumonisin Contamination and Its Source, Fusarium verticillioides, in Maize

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