Air-Liquid Interface System To Understand Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma

ABSTRACT Epstein-Barr virus (EBV) infects epithelial cells and is associated with epithelial malignancies. Although EBV reactivation is induced by epithelial differentiation, the available methods for differentiation are not widely used. In a recent study, Caves et al. (mSphere 3:e00152-18, 2018, ht...

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Autores principales:	Sharon E. Hopcraft, Cary A. Moody, Blossom Damania
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	ALI EBV Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/30e446a86888486fbd3c6bdf301b5465
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spelling	oai:doaj.org-article:30e446a86888486fbd3c6bdf301b54652021-11-15T15:25:51ZAir-Liquid Interface System To Understand Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma10.1128/mSphere.00350-182379-5042https://doaj.org/article/30e446a86888486fbd3c6bdf301b54652018-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00350-18https://doaj.org/toc/2379-5042ABSTRACT Epstein-Barr virus (EBV) infects epithelial cells and is associated with epithelial malignancies. Although EBV reactivation is induced by epithelial differentiation, the available methods for differentiation are not widely used. In a recent study, Caves et al. (mSphere 3:e00152-18, 2018, https://doi.org/10.1128/mSphere.00152-18) explored the use of a new transwell-based air-liquid interface (ALI) system to differentiate EBV-infected nasopharyngeal carcinoma cells. They found that cells cultured in the ALI system expressed markers of differentiation and supported complete EBV reactivation. This system offers an easy method for differentiation that could be widely adopted. This system could be extended to other epithelial cell types.Sharon E. HopcraftCary A. MoodyBlossom DamaniaAmerican Society for MicrobiologyarticleALIEBVMicrobiologyQR1-502ENmSphere, Vol 3, Iss 4 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	ALI EBV Microbiology QR1-502
spellingShingle	ALI EBV Microbiology QR1-502 Sharon E. Hopcraft Cary A. Moody Blossom Damania Air-Liquid Interface System To Understand Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma
description	ABSTRACT Epstein-Barr virus (EBV) infects epithelial cells and is associated with epithelial malignancies. Although EBV reactivation is induced by epithelial differentiation, the available methods for differentiation are not widely used. In a recent study, Caves et al. (mSphere 3:e00152-18, 2018, https://doi.org/10.1128/mSphere.00152-18) explored the use of a new transwell-based air-liquid interface (ALI) system to differentiate EBV-infected nasopharyngeal carcinoma cells. They found that cells cultured in the ALI system expressed markers of differentiation and supported complete EBV reactivation. This system offers an easy method for differentiation that could be widely adopted. This system could be extended to other epithelial cell types.
format	article
author	Sharon E. Hopcraft Cary A. Moody Blossom Damania
author_facet	Sharon E. Hopcraft Cary A. Moody Blossom Damania
author_sort	Sharon E. Hopcraft
title	Air-Liquid Interface System To Understand Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma
title_short	Air-Liquid Interface System To Understand Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma
title_full	Air-Liquid Interface System To Understand Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma
title_fullStr	Air-Liquid Interface System To Understand Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma
title_full_unstemmed	Air-Liquid Interface System To Understand Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma
title_sort	air-liquid interface system to understand epstein-barr virus-associated nasopharyngeal carcinoma
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/30e446a86888486fbd3c6bdf301b5465
work_keys_str_mv	AT sharonehopcraft airliquidinterfacesystemtounderstandepsteinbarrvirusassociatednasopharyngealcarcinoma AT caryamoody airliquidinterfacesystemtounderstandepsteinbarrvirusassociatednasopharyngealcarcinoma AT blossomdamania airliquidinterfacesystemtounderstandepsteinbarrvirusassociatednasopharyngealcarcinoma
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Air-Liquid Interface System To Understand Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma

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