Concomitant autoimmunity may be a predictor of more severe stages of endometriosis

Abstract Pathogenesis of endometriosis is still unclear and a role of both innate and adaptive immune system has been postulated. Some recent findings have revealed an increased risk to have concomitant autoimmune disease in women with endometriosis, but no study so far has investigated whether this...

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Autores principales:	Vanni Valeria Stella, Villanacci Roberta, Salmeri Noemi, Papaleo Enrico, Delprato Diana, Ottolina Jessica, Rovere-Querini Patrizia, Ferrari Stefano, Viganò Paola, Candiani Massimo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/30e56a2ea1a94f198b90d06b36169b34
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spelling	oai:doaj.org-article:30e56a2ea1a94f198b90d06b36169b342021-12-02T16:24:59ZConcomitant autoimmunity may be a predictor of more severe stages of endometriosis10.1038/s41598-021-94877-z2045-2322https://doaj.org/article/30e56a2ea1a94f198b90d06b36169b342021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94877-zhttps://doaj.org/toc/2045-2322Abstract Pathogenesis of endometriosis is still unclear and a role of both innate and adaptive immune system has been postulated. Some recent findings have revealed an increased risk to have concomitant autoimmune disease in women with endometriosis, but no study so far has investigated whether this association could affect endometriosis severity and stage. We retrospectively reviewed medical patients’ notes of women with a confirmed diagnosis of endometriosis who referred to our endometriosis outpatient clinic between January 2015 and December 2019. Cases (endometriosis and an autoimmune disease) were matched in a 1:3 ratio by age and study period with controls (endometriosis without history of autoimmunity). At univariate logistic analysis, concomitant autoimmunity (OR 2.63, 95% CI 1.64–4.21, p < 0.001) and the number of laparoscopic procedures performed (OR 2.81, 95% CI 1.45–5.43, p = 0.002) emerged as factors significantly associated with the likelihood of stage IV endometriosis. In the multivariate logistic regression model, concomitant autoimmunity remained a significant predictor of stage IV endometriosis (OR 2.54, 95% CI 1.57–4.10, p = 0.004), whereas the association between the number of laparoscopic procedures performed and stage IV endometriosis was found to be of borderline-significance (OR 2.70, 95% 1.37–5.30, p = 0.050). Our findings suggest that endometriosis is more severe in patients who are also affected by autoimmune disturbances after controlling for relevant confounders.Vanni Valeria StellaVillanacci RobertaSalmeri NoemiPapaleo EnricoDelprato DianaOttolina JessicaRovere-Querini PatriziaFerrari StefanoViganò PaolaCandiani MassimoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vanni Valeria Stella Villanacci Roberta Salmeri Noemi Papaleo Enrico Delprato Diana Ottolina Jessica Rovere-Querini Patrizia Ferrari Stefano Viganò Paola Candiani Massimo Concomitant autoimmunity may be a predictor of more severe stages of endometriosis
description	Abstract Pathogenesis of endometriosis is still unclear and a role of both innate and adaptive immune system has been postulated. Some recent findings have revealed an increased risk to have concomitant autoimmune disease in women with endometriosis, but no study so far has investigated whether this association could affect endometriosis severity and stage. We retrospectively reviewed medical patients’ notes of women with a confirmed diagnosis of endometriosis who referred to our endometriosis outpatient clinic between January 2015 and December 2019. Cases (endometriosis and an autoimmune disease) were matched in a 1:3 ratio by age and study period with controls (endometriosis without history of autoimmunity). At univariate logistic analysis, concomitant autoimmunity (OR 2.63, 95% CI 1.64–4.21, p < 0.001) and the number of laparoscopic procedures performed (OR 2.81, 95% CI 1.45–5.43, p = 0.002) emerged as factors significantly associated with the likelihood of stage IV endometriosis. In the multivariate logistic regression model, concomitant autoimmunity remained a significant predictor of stage IV endometriosis (OR 2.54, 95% CI 1.57–4.10, p = 0.004), whereas the association between the number of laparoscopic procedures performed and stage IV endometriosis was found to be of borderline-significance (OR 2.70, 95% 1.37–5.30, p = 0.050). Our findings suggest that endometriosis is more severe in patients who are also affected by autoimmune disturbances after controlling for relevant confounders.
format	article
author	Vanni Valeria Stella Villanacci Roberta Salmeri Noemi Papaleo Enrico Delprato Diana Ottolina Jessica Rovere-Querini Patrizia Ferrari Stefano Viganò Paola Candiani Massimo
author_facet	Vanni Valeria Stella Villanacci Roberta Salmeri Noemi Papaleo Enrico Delprato Diana Ottolina Jessica Rovere-Querini Patrizia Ferrari Stefano Viganò Paola Candiani Massimo
author_sort	Vanni Valeria Stella
title	Concomitant autoimmunity may be a predictor of more severe stages of endometriosis
title_short	Concomitant autoimmunity may be a predictor of more severe stages of endometriosis
title_full	Concomitant autoimmunity may be a predictor of more severe stages of endometriosis
title_fullStr	Concomitant autoimmunity may be a predictor of more severe stages of endometriosis
title_full_unstemmed	Concomitant autoimmunity may be a predictor of more severe stages of endometriosis
title_sort	concomitant autoimmunity may be a predictor of more severe stages of endometriosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/30e56a2ea1a94f198b90d06b36169b34
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Concomitant autoimmunity may be a predictor of more severe stages of endometriosis

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