Evaluation of primary breast cancers using dedicated breast PET and whole-body PET

Abstract Metabolic imaging of the primary breast tumor with 18F-fluorodeoxyglucose ([18F]FDG) PET may assist in predicting treatment response in the neoadjuvant chemotherapy (NAC) setting. Dedicated breast PET (dbPET) is a high-resolution imaging modality with demonstrated ability in highlighting in...

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Autores principales:	Deep K. Hathi, Wen Li, Youngho Seo, Robert R. Flavell, John Kornak, Benjamin L. Franc, Bonnie N. Joe, Laura J. Esserman, Nola M. Hylton, Ella F. Jones
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/30e6a4a7f89b4329acae5a910d765f06
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spelling	oai:doaj.org-article:30e6a4a7f89b4329acae5a910d765f062021-12-02T12:40:41ZEvaluation of primary breast cancers using dedicated breast PET and whole-body PET10.1038/s41598-020-78865-32045-2322https://doaj.org/article/30e6a4a7f89b4329acae5a910d765f062020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78865-3https://doaj.org/toc/2045-2322Abstract Metabolic imaging of the primary breast tumor with 18F-fluorodeoxyglucose ([18F]FDG) PET may assist in predicting treatment response in the neoadjuvant chemotherapy (NAC) setting. Dedicated breast PET (dbPET) is a high-resolution imaging modality with demonstrated ability in highlighting intratumoral heterogeneity and identifying small lesions in the breast volume. In this study, we characterized similarities and differences in the uptake of [18F]FDG in dbPET compared to whole-body PET (wbPET) in a cohort of ten patients with biopsy-confirmed, locally advanced breast cancer at the pre-treatment timepoint. Patients received bilateral dbPET and wbPET following administration of 186 MBq and 307 MBq [18F]FDG on separate days, respectively. [18F]FDG uptake measurements and 20 radiomic features based on morphology, tumor intensity, and texture were calculated and compared. There was a fivefold increase in SULpeak for dbPET (median difference (95% CI): 4.0 mL−1 (1.8–6.4 mL−1), p = 0.006). Additionally, spatial heterogeneity features showed statistically significant differences between dbPET and wbPET. The higher [18F]FDG uptake in dbPET highlighted the dynamic range of this breast-specific imaging modality. Combining with the higher spatial resolution, dbPET may be able to detect treatment response in the primary tumor during NAC, and future studies with larger cohorts are warranted.Deep K. HathiWen LiYoungho SeoRobert R. FlavellJohn KornakBenjamin L. FrancBonnie N. JoeLaura J. EssermanNola M. HyltonElla F. JonesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Deep K. Hathi Wen Li Youngho Seo Robert R. Flavell John Kornak Benjamin L. Franc Bonnie N. Joe Laura J. Esserman Nola M. Hylton Ella F. Jones Evaluation of primary breast cancers using dedicated breast PET and whole-body PET
description	Abstract Metabolic imaging of the primary breast tumor with 18F-fluorodeoxyglucose ([18F]FDG) PET may assist in predicting treatment response in the neoadjuvant chemotherapy (NAC) setting. Dedicated breast PET (dbPET) is a high-resolution imaging modality with demonstrated ability in highlighting intratumoral heterogeneity and identifying small lesions in the breast volume. In this study, we characterized similarities and differences in the uptake of [18F]FDG in dbPET compared to whole-body PET (wbPET) in a cohort of ten patients with biopsy-confirmed, locally advanced breast cancer at the pre-treatment timepoint. Patients received bilateral dbPET and wbPET following administration of 186 MBq and 307 MBq [18F]FDG on separate days, respectively. [18F]FDG uptake measurements and 20 radiomic features based on morphology, tumor intensity, and texture were calculated and compared. There was a fivefold increase in SULpeak for dbPET (median difference (95% CI): 4.0 mL−1 (1.8–6.4 mL−1), p = 0.006). Additionally, spatial heterogeneity features showed statistically significant differences between dbPET and wbPET. The higher [18F]FDG uptake in dbPET highlighted the dynamic range of this breast-specific imaging modality. Combining with the higher spatial resolution, dbPET may be able to detect treatment response in the primary tumor during NAC, and future studies with larger cohorts are warranted.
format	article
author	Deep K. Hathi Wen Li Youngho Seo Robert R. Flavell John Kornak Benjamin L. Franc Bonnie N. Joe Laura J. Esserman Nola M. Hylton Ella F. Jones
author_facet	Deep K. Hathi Wen Li Youngho Seo Robert R. Flavell John Kornak Benjamin L. Franc Bonnie N. Joe Laura J. Esserman Nola M. Hylton Ella F. Jones
author_sort	Deep K. Hathi
title	Evaluation of primary breast cancers using dedicated breast PET and whole-body PET
title_short	Evaluation of primary breast cancers using dedicated breast PET and whole-body PET
title_full	Evaluation of primary breast cancers using dedicated breast PET and whole-body PET
title_fullStr	Evaluation of primary breast cancers using dedicated breast PET and whole-body PET
title_full_unstemmed	Evaluation of primary breast cancers using dedicated breast PET and whole-body PET
title_sort	evaluation of primary breast cancers using dedicated breast pet and whole-body pet
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/30e6a4a7f89b4329acae5a910d765f06
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Evaluation of primary breast cancers using dedicated breast PET and whole-body PET

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