Flagellar cAMP signaling controls trypanosome progression through host tissues

Trypanosoma brucei probably relies on chemotactic signals for movement through tsetse fly tissues, but the molecular basis is unknown. Here, the authors show that flagellar cAMP signaling is required for traversal of the peritrophic matrix and that, without it, parasites are trapped in the midgut lu...

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Autores principales: Sebastian Shaw, Stephanie F. DeMarco, Ruth Rehmann, Tanja Wenzler, Francesca Florini, Isabel Roditi, Kent L. Hill
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/30f4254f1f9248b0a285b1c1494715d5
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spelling oai:doaj.org-article:30f4254f1f9248b0a285b1c1494715d52021-12-02T15:35:54ZFlagellar cAMP signaling controls trypanosome progression through host tissues10.1038/s41467-019-08696-y2041-1723https://doaj.org/article/30f4254f1f9248b0a285b1c1494715d52019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08696-yhttps://doaj.org/toc/2041-1723Trypanosoma brucei probably relies on chemotactic signals for movement through tsetse fly tissues, but the molecular basis is unknown. Here, the authors show that flagellar cAMP signaling is required for traversal of the peritrophic matrix and that, without it, parasites are trapped in the midgut lumen.Sebastian ShawStephanie F. DeMarcoRuth RehmannTanja WenzlerFrancesca FloriniIsabel RoditiKent L. HillNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sebastian Shaw
Stephanie F. DeMarco
Ruth Rehmann
Tanja Wenzler
Francesca Florini
Isabel Roditi
Kent L. Hill
Flagellar cAMP signaling controls trypanosome progression through host tissues
description Trypanosoma brucei probably relies on chemotactic signals for movement through tsetse fly tissues, but the molecular basis is unknown. Here, the authors show that flagellar cAMP signaling is required for traversal of the peritrophic matrix and that, without it, parasites are trapped in the midgut lumen.
format article
author Sebastian Shaw
Stephanie F. DeMarco
Ruth Rehmann
Tanja Wenzler
Francesca Florini
Isabel Roditi
Kent L. Hill
author_facet Sebastian Shaw
Stephanie F. DeMarco
Ruth Rehmann
Tanja Wenzler
Francesca Florini
Isabel Roditi
Kent L. Hill
author_sort Sebastian Shaw
title Flagellar cAMP signaling controls trypanosome progression through host tissues
title_short Flagellar cAMP signaling controls trypanosome progression through host tissues
title_full Flagellar cAMP signaling controls trypanosome progression through host tissues
title_fullStr Flagellar cAMP signaling controls trypanosome progression through host tissues
title_full_unstemmed Flagellar cAMP signaling controls trypanosome progression through host tissues
title_sort flagellar camp signaling controls trypanosome progression through host tissues
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/30f4254f1f9248b0a285b1c1494715d5
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