Flagellar cAMP signaling controls trypanosome progression through host tissues
Trypanosoma brucei probably relies on chemotactic signals for movement through tsetse fly tissues, but the molecular basis is unknown. Here, the authors show that flagellar cAMP signaling is required for traversal of the peritrophic matrix and that, without it, parasites are trapped in the midgut lu...
Guardado en:
Autores principales: | , , , , , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
|
Materias: | |
Acceso en línea: | https://doaj.org/article/30f4254f1f9248b0a285b1c1494715d5 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:30f4254f1f9248b0a285b1c1494715d5 |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:30f4254f1f9248b0a285b1c1494715d52021-12-02T15:35:54ZFlagellar cAMP signaling controls trypanosome progression through host tissues10.1038/s41467-019-08696-y2041-1723https://doaj.org/article/30f4254f1f9248b0a285b1c1494715d52019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08696-yhttps://doaj.org/toc/2041-1723Trypanosoma brucei probably relies on chemotactic signals for movement through tsetse fly tissues, but the molecular basis is unknown. Here, the authors show that flagellar cAMP signaling is required for traversal of the peritrophic matrix and that, without it, parasites are trapped in the midgut lumen.Sebastian ShawStephanie F. DeMarcoRuth RehmannTanja WenzlerFrancesca FloriniIsabel RoditiKent L. HillNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
Science Q |
spellingShingle |
Science Q Sebastian Shaw Stephanie F. DeMarco Ruth Rehmann Tanja Wenzler Francesca Florini Isabel Roditi Kent L. Hill Flagellar cAMP signaling controls trypanosome progression through host tissues |
description |
Trypanosoma brucei probably relies on chemotactic signals for movement through tsetse fly tissues, but the molecular basis is unknown. Here, the authors show that flagellar cAMP signaling is required for traversal of the peritrophic matrix and that, without it, parasites are trapped in the midgut lumen. |
format |
article |
author |
Sebastian Shaw Stephanie F. DeMarco Ruth Rehmann Tanja Wenzler Francesca Florini Isabel Roditi Kent L. Hill |
author_facet |
Sebastian Shaw Stephanie F. DeMarco Ruth Rehmann Tanja Wenzler Francesca Florini Isabel Roditi Kent L. Hill |
author_sort |
Sebastian Shaw |
title |
Flagellar cAMP signaling controls trypanosome progression through host tissues |
title_short |
Flagellar cAMP signaling controls trypanosome progression through host tissues |
title_full |
Flagellar cAMP signaling controls trypanosome progression through host tissues |
title_fullStr |
Flagellar cAMP signaling controls trypanosome progression through host tissues |
title_full_unstemmed |
Flagellar cAMP signaling controls trypanosome progression through host tissues |
title_sort |
flagellar camp signaling controls trypanosome progression through host tissues |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/30f4254f1f9248b0a285b1c1494715d5 |
work_keys_str_mv |
AT sebastianshaw flagellarcampsignalingcontrolstrypanosomeprogressionthroughhosttissues AT stephaniefdemarco flagellarcampsignalingcontrolstrypanosomeprogressionthroughhosttissues AT ruthrehmann flagellarcampsignalingcontrolstrypanosomeprogressionthroughhosttissues AT tanjawenzler flagellarcampsignalingcontrolstrypanosomeprogressionthroughhosttissues AT francescaflorini flagellarcampsignalingcontrolstrypanosomeprogressionthroughhosttissues AT isabelroditi flagellarcampsignalingcontrolstrypanosomeprogressionthroughhosttissues AT kentlhill flagellarcampsignalingcontrolstrypanosomeprogressionthroughhosttissues |
_version_ |
1718386402800959488 |