Hierarchical ultrastructure: An overview of what is known about tendons and future perspective for tendon engineering

Abnormal tendons are rarely ever repaired to the natural structure and morphology of normal tendons. To better guide the repair and regeneration of injured tendons through a tissue engineering method, it is necessary to have insights into the internal morphology, organization, and composition of nat...

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Autores principales:	Shichen Zhang, Wei Ju, Xiaoyi Chen, Yanyan Zhao, Lingchong Feng, Zi Yin, Xiao Chen
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2022
Materias:	Tendon Collagen fibrillogenesis Extracellular matrix FIB-SEM Biomimetic Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/30fb85b194954060ac2dd9b8c8da388b
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spelling	oai:doaj.org-article:30fb85b194954060ac2dd9b8c8da388b2021-11-04T04:35:01ZHierarchical ultrastructure: An overview of what is known about tendons and future perspective for tendon engineering2452-199X10.1016/j.bioactmat.2021.06.007https://doaj.org/article/30fb85b194954060ac2dd9b8c8da388b2022-02-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2452199X21002917https://doaj.org/toc/2452-199XAbnormal tendons are rarely ever repaired to the natural structure and morphology of normal tendons. To better guide the repair and regeneration of injured tendons through a tissue engineering method, it is necessary to have insights into the internal morphology, organization, and composition of natural tendons. This review summarized recent researches on the structure and function of the extracellular matrix (ECM) components of tendons and highlight the application of multiple detection methodologies concerning the structure of ECMs. In addition, we look forward to the future of multi-dimensional biomaterial design methods and the potential of structural repair for tendon ECM components. In addition, focus is placed on the macro to micro detection methods for tendons, and current techniques for evaluating the extracellular matrix of tendons at the micro level are introduced in detail. Finally, emphasis is given to future extracellular matrix detection methods, as well as to how future efforts could concentrate on fabricating the biomimetic tendons.Shichen ZhangWei JuXiaoyi ChenYanyan ZhaoLingchong FengZi YinXiao ChenKeAi Communications Co., Ltd.articleTendonCollagen fibrillogenesisExtracellular matrixFIB-SEMBiomimeticMaterials of engineering and construction. Mechanics of materialsTA401-492Biology (General)QH301-705.5ENBioactive Materials, Vol 8, Iss , Pp 124-139 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Tendon Collagen fibrillogenesis Extracellular matrix FIB-SEM Biomimetic Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
spellingShingle	Tendon Collagen fibrillogenesis Extracellular matrix FIB-SEM Biomimetic Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5 Shichen Zhang Wei Ju Xiaoyi Chen Yanyan Zhao Lingchong Feng Zi Yin Xiao Chen Hierarchical ultrastructure: An overview of what is known about tendons and future perspective for tendon engineering
description	Abnormal tendons are rarely ever repaired to the natural structure and morphology of normal tendons. To better guide the repair and regeneration of injured tendons through a tissue engineering method, it is necessary to have insights into the internal morphology, organization, and composition of natural tendons. This review summarized recent researches on the structure and function of the extracellular matrix (ECM) components of tendons and highlight the application of multiple detection methodologies concerning the structure of ECMs. In addition, we look forward to the future of multi-dimensional biomaterial design methods and the potential of structural repair for tendon ECM components. In addition, focus is placed on the macro to micro detection methods for tendons, and current techniques for evaluating the extracellular matrix of tendons at the micro level are introduced in detail. Finally, emphasis is given to future extracellular matrix detection methods, as well as to how future efforts could concentrate on fabricating the biomimetic tendons.
format	article
author	Shichen Zhang Wei Ju Xiaoyi Chen Yanyan Zhao Lingchong Feng Zi Yin Xiao Chen
author_facet	Shichen Zhang Wei Ju Xiaoyi Chen Yanyan Zhao Lingchong Feng Zi Yin Xiao Chen
author_sort	Shichen Zhang
title	Hierarchical ultrastructure: An overview of what is known about tendons and future perspective for tendon engineering
title_short	Hierarchical ultrastructure: An overview of what is known about tendons and future perspective for tendon engineering
title_full	Hierarchical ultrastructure: An overview of what is known about tendons and future perspective for tendon engineering
title_fullStr	Hierarchical ultrastructure: An overview of what is known about tendons and future perspective for tendon engineering
title_full_unstemmed	Hierarchical ultrastructure: An overview of what is known about tendons and future perspective for tendon engineering
title_sort	hierarchical ultrastructure: an overview of what is known about tendons and future perspective for tendon engineering
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/30fb85b194954060ac2dd9b8c8da388b
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Hierarchical ultrastructure: An overview of what is known about tendons and future perspective for tendon engineering

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