Liriopogons (Genera Ophiopogon and Liriope, Asparagaceae): A Critical Review of the Phytochemical and Pharmacological Research

The closely related genera Liriope and Ophiopogon (Asparagaceae), collectively known in English as liriopogons, have similar therapeutic uses in treating cough, rheumatoid arthritis, and cleaning heat. The main aim of this review is to understand the current phytochemical and pharmacological knowled...

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Autores principales:	Feiyi Lei, Caroline S. Weckerle, Michael Heinrich
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	ophiopogon liriope liriopogons phytochemistry pharmacology critical review Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/30fc296947674494a9c25502c55fe6d2
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spelling	oai:doaj.org-article:30fc296947674494a9c25502c55fe6d22021-12-03T07:00:58ZLiriopogons (Genera Ophiopogon and Liriope, Asparagaceae): A Critical Review of the Phytochemical and Pharmacological Research1663-981210.3389/fphar.2021.769929https://doaj.org/article/30fc296947674494a9c25502c55fe6d22021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.769929/fullhttps://doaj.org/toc/1663-9812The closely related genera Liriope and Ophiopogon (Asparagaceae), collectively known in English as liriopogons, have similar therapeutic uses in treating cough, rheumatoid arthritis, and cleaning heat. The main aim of this review is to understand the current phytochemical and pharmacological knowledge including an assessment of the quality of the scientific evidence. A literature search was conducted in line with PRISMA guidelines, by retrieving available information up to 2020 from five online resources. The bioactive metabolites of liriopogons include steroidal saponins, flavonoids, polysaccharides, organic acids, phenols. Cardiovascular protective, anti-inflammatory, anti-diabetic, anti-oxidant, anti-cancer, neuroprotective, anti-viral, anti-acute myeloid leukemia and hepatoprotective effects have been at the center of attention. From a toxicological perspective Ophiopogon japonicus seems to be safe. Some problems with the quality of the pharmacological evidence stand out including the application of excessive dose level and methodological problems in the design. Additionally, a reasonable link between local/traditional uses and pharmacological assessment is often vague or not reflected in the text. Future researches on liriopogons are required to use rigorous scientific approaches in research on evidence-based natural products for the future benefits of patients.Feiyi LeiCaroline S. WeckerleMichael HeinrichFrontiers Media S.A.articleophiopogonliriopeliriopogonsphytochemistrypharmacologycritical reviewTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ophiopogon liriope liriopogons phytochemistry pharmacology critical review Therapeutics. Pharmacology RM1-950
spellingShingle	ophiopogon liriope liriopogons phytochemistry pharmacology critical review Therapeutics. Pharmacology RM1-950 Feiyi Lei Caroline S. Weckerle Michael Heinrich Liriopogons (Genera Ophiopogon and Liriope, Asparagaceae): A Critical Review of the Phytochemical and Pharmacological Research
description	The closely related genera Liriope and Ophiopogon (Asparagaceae), collectively known in English as liriopogons, have similar therapeutic uses in treating cough, rheumatoid arthritis, and cleaning heat. The main aim of this review is to understand the current phytochemical and pharmacological knowledge including an assessment of the quality of the scientific evidence. A literature search was conducted in line with PRISMA guidelines, by retrieving available information up to 2020 from five online resources. The bioactive metabolites of liriopogons include steroidal saponins, flavonoids, polysaccharides, organic acids, phenols. Cardiovascular protective, anti-inflammatory, anti-diabetic, anti-oxidant, anti-cancer, neuroprotective, anti-viral, anti-acute myeloid leukemia and hepatoprotective effects have been at the center of attention. From a toxicological perspective Ophiopogon japonicus seems to be safe. Some problems with the quality of the pharmacological evidence stand out including the application of excessive dose level and methodological problems in the design. Additionally, a reasonable link between local/traditional uses and pharmacological assessment is often vague or not reflected in the text. Future researches on liriopogons are required to use rigorous scientific approaches in research on evidence-based natural products for the future benefits of patients.
format	article
author	Feiyi Lei Caroline S. Weckerle Michael Heinrich
author_facet	Feiyi Lei Caroline S. Weckerle Michael Heinrich
author_sort	Feiyi Lei
title	Liriopogons (Genera Ophiopogon and Liriope, Asparagaceae): A Critical Review of the Phytochemical and Pharmacological Research
title_short	Liriopogons (Genera Ophiopogon and Liriope, Asparagaceae): A Critical Review of the Phytochemical and Pharmacological Research
title_full	Liriopogons (Genera Ophiopogon and Liriope, Asparagaceae): A Critical Review of the Phytochemical and Pharmacological Research
title_fullStr	Liriopogons (Genera Ophiopogon and Liriope, Asparagaceae): A Critical Review of the Phytochemical and Pharmacological Research
title_full_unstemmed	Liriopogons (Genera Ophiopogon and Liriope, Asparagaceae): A Critical Review of the Phytochemical and Pharmacological Research
title_sort	liriopogons (genera ophiopogon and liriope, asparagaceae): a critical review of the phytochemical and pharmacological research
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/30fc296947674494a9c25502c55fe6d2
work_keys_str_mv	AT feiyilei liriopogonsgeneraophiopogonandliriopeasparagaceaeacriticalreviewofthephytochemicalandpharmacologicalresearch AT carolinesweckerle liriopogonsgeneraophiopogonandliriopeasparagaceaeacriticalreviewofthephytochemicalandpharmacologicalresearch AT michaelheinrich liriopogonsgeneraophiopogonandliriopeasparagaceaeacriticalreviewofthephytochemicalandpharmacologicalresearch
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Liriopogons (Genera Ophiopogon and Liriope, Asparagaceae): A Critical Review of the Phytochemical and Pharmacological Research

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