The ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells

γδT cells are activated by phosphoantigens, and ABCA1 is involved in cholesterol transport. Here the authors link these ideas to show that ABCA1, apoA-I and BTN3A1 regulate extracellular phosphoantigen release by dendritic cells, and implicate ABCA1 in mevalonate-mediated activation of Vγ9Vδ2 T cell...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Barbara Castella, Joanna Kopecka, Patrizia Sciancalepore, Giorgia Mandili, Myriam Foglietta, Nico Mitro, Donatella Caruso, Francesco Novelli, Chiara Riganti, Massimo Massaia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/30ff31dddf594bef8c44c2fafe50d420
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:30ff31dddf594bef8c44c2fafe50d420
record_format	dspace
spelling	oai:doaj.org-article:30ff31dddf594bef8c44c2fafe50d4202021-12-02T14:40:59ZThe ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells10.1038/ncomms156632041-1723https://doaj.org/article/30ff31dddf594bef8c44c2fafe50d4202017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15663https://doaj.org/toc/2041-1723γδT cells are activated by phosphoantigens, and ABCA1 is involved in cholesterol transport. Here the authors link these ideas to show that ABCA1, apoA-I and BTN3A1 regulate extracellular phosphoantigen release by dendritic cells, and implicate ABCA1 in mevalonate-mediated activation of Vγ9Vδ2 T cells.Barbara CastellaJoanna KopeckaPatrizia SciancaleporeGiorgia MandiliMyriam FogliettaNico MitroDonatella CarusoFrancesco NovelliChiara RigantiMassimo MassaiaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Barbara Castella Joanna Kopecka Patrizia Sciancalepore Giorgia Mandili Myriam Foglietta Nico Mitro Donatella Caruso Francesco Novelli Chiara Riganti Massimo Massaia The ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells
description	γδT cells are activated by phosphoantigens, and ABCA1 is involved in cholesterol transport. Here the authors link these ideas to show that ABCA1, apoA-I and BTN3A1 regulate extracellular phosphoantigen release by dendritic cells, and implicate ABCA1 in mevalonate-mediated activation of Vγ9Vδ2 T cells.
format	article
author	Barbara Castella Joanna Kopecka Patrizia Sciancalepore Giorgia Mandili Myriam Foglietta Nico Mitro Donatella Caruso Francesco Novelli Chiara Riganti Massimo Massaia
author_facet	Barbara Castella Joanna Kopecka Patrizia Sciancalepore Giorgia Mandili Myriam Foglietta Nico Mitro Donatella Caruso Francesco Novelli Chiara Riganti Massimo Massaia
author_sort	Barbara Castella
title	The ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells
title_short	The ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells
title_full	The ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells
title_fullStr	The ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells
title_full_unstemmed	The ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells
title_sort	atp-binding cassette transporter a1 regulates phosphoantigen release and vγ9vδ2 t cell activation by dendritic cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/30ff31dddf594bef8c44c2fafe50d420
work_keys_str_mv	AT barbaracastella theatpbindingcassettetransportera1regulatesphosphoantigenreleaseandvg9vd2tcellactivationbydendriticcells AT joannakopecka theatpbindingcassettetransportera1regulatesphosphoantigenreleaseandvg9vd2tcellactivationbydendriticcells AT patriziasciancalepore theatpbindingcassettetransportera1regulatesphosphoantigenreleaseandvg9vd2tcellactivationbydendriticcells AT giorgiamandili theatpbindingcassettetransportera1regulatesphosphoantigenreleaseandvg9vd2tcellactivationbydendriticcells AT myriamfoglietta theatpbindingcassettetransportera1regulatesphosphoantigenreleaseandvg9vd2tcellactivationbydendriticcells AT nicomitro theatpbindingcassettetransportera1regulatesphosphoantigenreleaseandvg9vd2tcellactivationbydendriticcells AT donatellacaruso theatpbindingcassettetransportera1regulatesphosphoantigenreleaseandvg9vd2tcellactivationbydendriticcells AT francesconovelli theatpbindingcassettetransportera1regulatesphosphoantigenreleaseandvg9vd2tcellactivationbydendriticcells AT chiarariganti theatpbindingcassettetransportera1regulatesphosphoantigenreleaseandvg9vd2tcellactivationbydendriticcells AT massimomassaia theatpbindingcassettetransportera1regulatesphosphoantigenreleaseandvg9vd2tcellactivationbydendriticcells AT barbaracastella atpbindingcassettetransportera1regulatesphosphoantigenreleaseandvg9vd2tcellactivationbydendriticcells AT joannakopecka atpbindingcassettetransportera1regulatesphosphoantigenreleaseandvg9vd2tcellactivationbydendriticcells AT patriziasciancalepore atpbindingcassettetransportera1regulatesphosphoantigenreleaseandvg9vd2tcellactivationbydendriticcells AT giorgiamandili atpbindingcassettetransportera1regulatesphosphoantigenreleaseandvg9vd2tcellactivationbydendriticcells AT myriamfoglietta atpbindingcassettetransportera1regulatesphosphoantigenreleaseandvg9vd2tcellactivationbydendriticcells AT nicomitro atpbindingcassettetransportera1regulatesphosphoantigenreleaseandvg9vd2tcellactivationbydendriticcells AT donatellacaruso atpbindingcassettetransportera1regulatesphosphoantigenreleaseandvg9vd2tcellactivationbydendriticcells AT francesconovelli atpbindingcassettetransportera1regulatesphosphoantigenreleaseandvg9vd2tcellactivationbydendriticcells AT chiarariganti atpbindingcassettetransportera1regulatesphosphoantigenreleaseandvg9vd2tcellactivationbydendriticcells AT massimomassaia atpbindingcassettetransportera1regulatesphosphoantigenreleaseandvg9vd2tcellactivationbydendriticcells
_version_	1718390043699052544

The ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells

Ejemplares similares