Mechanism linking diabetes mellitus and obesity

Abdullah S Al-Goblan,1 Mohammed A Al-Alfi,1 Muhammad Z Khan2 1Diabetes Center, King Fahad Specialist Hospital, Buraidah, Qassim, Kingdom of Saudi Arabia; 2Sulaiman AlRajhi Colleges, Al Bukairiyah, Kingdom of Saudi Arabia Abstract: Body mass index has a strong relationship to diabetes and insulin r...

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Autores principales:	Al-Goblan AS, Al-Alfi MA, Khan MZ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/3102665fdafe416bb7b42945cbdd2167
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spelling	oai:doaj.org-article:3102665fdafe416bb7b42945cbdd21672021-12-02T06:52:53ZMechanism linking diabetes mellitus and obesity1178-7007https://doaj.org/article/3102665fdafe416bb7b42945cbdd21672014-12-01T00:00:00Zhttp://www.dovepress.com/mechanism-linking-diabetes-mellitus-and-obesity-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007 Abdullah S Al-Goblan,1 Mohammed A Al-Alfi,1 Muhammad Z Khan2 1Diabetes Center, King Fahad Specialist Hospital, Buraidah, Qassim, Kingdom of Saudi Arabia; 2Sulaiman AlRajhi Colleges, Al Bukairiyah, Kingdom of Saudi Arabia Abstract: Body mass index has a strong relationship to diabetes and insulin resistance. In obese individuals, the amount of nonesterified fatty acids, glycerol, hormones, cytokines, proinflammatory markers, and other substances that are involved in the development of insulin resistance, is increased. The pathogenesis in the development of diabetes is based on the fact that the β-islet cells of the pancreas are impaired, causing a lack of control of blood glucose. The development of diabetes becomes more inevitable if the failure of β-islet cells of the pancreas is accompanied by insulin resistance. Weight gain and body mass are central to the formation and rising incidence of type 1 and type 2 diabetes. This literature review will demonstrate the facts that link obesity with insulin resistance and pancreatic β-cell dysfunction. In conclusion, new approaches in managing and preventing diabetes in obese individuals must be studied and investigated based on the facts. Keywords: diabetes mellitus, obesity, insulin resistanceAl-Goblan ASAl-Alfi MAKhan MZDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2014, Iss default, Pp 587-591 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Al-Goblan AS Al-Alfi MA Khan MZ Mechanism linking diabetes mellitus and obesity
description	Abdullah S Al-Goblan,1 Mohammed A Al-Alfi,1 Muhammad Z Khan2 1Diabetes Center, King Fahad Specialist Hospital, Buraidah, Qassim, Kingdom of Saudi Arabia; 2Sulaiman AlRajhi Colleges, Al Bukairiyah, Kingdom of Saudi Arabia Abstract: Body mass index has a strong relationship to diabetes and insulin resistance. In obese individuals, the amount of nonesterified fatty acids, glycerol, hormones, cytokines, proinflammatory markers, and other substances that are involved in the development of insulin resistance, is increased. The pathogenesis in the development of diabetes is based on the fact that the β-islet cells of the pancreas are impaired, causing a lack of control of blood glucose. The development of diabetes becomes more inevitable if the failure of β-islet cells of the pancreas is accompanied by insulin resistance. Weight gain and body mass are central to the formation and rising incidence of type 1 and type 2 diabetes. This literature review will demonstrate the facts that link obesity with insulin resistance and pancreatic β-cell dysfunction. In conclusion, new approaches in managing and preventing diabetes in obese individuals must be studied and investigated based on the facts. Keywords: diabetes mellitus, obesity, insulin resistance
format	article
author	Al-Goblan AS Al-Alfi MA Khan MZ
author_facet	Al-Goblan AS Al-Alfi MA Khan MZ
author_sort	Al-Goblan AS
title	Mechanism linking diabetes mellitus and obesity
title_short	Mechanism linking diabetes mellitus and obesity
title_full	Mechanism linking diabetes mellitus and obesity
title_fullStr	Mechanism linking diabetes mellitus and obesity
title_full_unstemmed	Mechanism linking diabetes mellitus and obesity
title_sort	mechanism linking diabetes mellitus and obesity
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/3102665fdafe416bb7b42945cbdd2167
work_keys_str_mv	AT algoblanas mechanismlinkingdiabetesmellitusandobesity AT alalfima mechanismlinkingdiabetesmellitusandobesity AT khanmz mechanismlinkingdiabetesmellitusandobesity
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Mechanism linking diabetes mellitus and obesity

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