Deep brain electrical neurofeedback allows Parkinson patients to control pathological oscillations and quicken movements

Abstract Parkinsonian motor symptoms are linked to pathologically increased beta-oscillations in the basal ganglia. While pharmacological treatment and deep brain stimulation (DBS) reduce these pathological oscillations concomitantly with improving motor performance, we set out to explore neurofeedb...

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Autores principales:	Oliver Bichsel, Lennart H. Stieglitz, Markus F. Oertel, Christian R. Baumann, Roger Gassert, Lukas L. Imbach
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3103e0c234be4623b5f9b355da9277bf
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spelling	oai:doaj.org-article:3103e0c234be4623b5f9b355da9277bf2021-12-02T15:51:16ZDeep brain electrical neurofeedback allows Parkinson patients to control pathological oscillations and quicken movements10.1038/s41598-021-87031-22045-2322https://doaj.org/article/3103e0c234be4623b5f9b355da9277bf2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87031-2https://doaj.org/toc/2045-2322Abstract Parkinsonian motor symptoms are linked to pathologically increased beta-oscillations in the basal ganglia. While pharmacological treatment and deep brain stimulation (DBS) reduce these pathological oscillations concomitantly with improving motor performance, we set out to explore neurofeedback as an endogenous modulatory method. We implemented real-time processing of pathological subthalamic beta oscillations through implanted DBS electrodes to provide deep brain electrical neurofeedback. Patients volitionally controlled ongoing beta-oscillatory activity by visual neurofeedback within minutes of training. During a single one-hour training session, the reduction of beta-oscillatory activity became gradually stronger and we observed improved motor performance. Lastly, endogenous control over deep brain activity was possible even after removing visual neurofeedback, suggesting that neurofeedback-acquired strategies were retained in the short-term. Moreover, we observed motor improvement when the learnt mental strategies were applied 2 days later without neurofeedback. Further training of deep brain neurofeedback might provide therapeutic benefits for Parkinson patients by improving symptom control using strategies optimized through neurofeedback.Oliver BichselLennart H. StieglitzMarkus F. OertelChristian R. BaumannRoger GassertLukas L. ImbachNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Oliver Bichsel Lennart H. Stieglitz Markus F. Oertel Christian R. Baumann Roger Gassert Lukas L. Imbach Deep brain electrical neurofeedback allows Parkinson patients to control pathological oscillations and quicken movements
description	Abstract Parkinsonian motor symptoms are linked to pathologically increased beta-oscillations in the basal ganglia. While pharmacological treatment and deep brain stimulation (DBS) reduce these pathological oscillations concomitantly with improving motor performance, we set out to explore neurofeedback as an endogenous modulatory method. We implemented real-time processing of pathological subthalamic beta oscillations through implanted DBS electrodes to provide deep brain electrical neurofeedback. Patients volitionally controlled ongoing beta-oscillatory activity by visual neurofeedback within minutes of training. During a single one-hour training session, the reduction of beta-oscillatory activity became gradually stronger and we observed improved motor performance. Lastly, endogenous control over deep brain activity was possible even after removing visual neurofeedback, suggesting that neurofeedback-acquired strategies were retained in the short-term. Moreover, we observed motor improvement when the learnt mental strategies were applied 2 days later without neurofeedback. Further training of deep brain neurofeedback might provide therapeutic benefits for Parkinson patients by improving symptom control using strategies optimized through neurofeedback.
format	article
author	Oliver Bichsel Lennart H. Stieglitz Markus F. Oertel Christian R. Baumann Roger Gassert Lukas L. Imbach
author_facet	Oliver Bichsel Lennart H. Stieglitz Markus F. Oertel Christian R. Baumann Roger Gassert Lukas L. Imbach
author_sort	Oliver Bichsel
title	Deep brain electrical neurofeedback allows Parkinson patients to control pathological oscillations and quicken movements
title_short	Deep brain electrical neurofeedback allows Parkinson patients to control pathological oscillations and quicken movements
title_full	Deep brain electrical neurofeedback allows Parkinson patients to control pathological oscillations and quicken movements
title_fullStr	Deep brain electrical neurofeedback allows Parkinson patients to control pathological oscillations and quicken movements
title_full_unstemmed	Deep brain electrical neurofeedback allows Parkinson patients to control pathological oscillations and quicken movements
title_sort	deep brain electrical neurofeedback allows parkinson patients to control pathological oscillations and quicken movements
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3103e0c234be4623b5f9b355da9277bf
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Deep brain electrical neurofeedback allows Parkinson patients to control pathological oscillations and quicken movements

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