Sensitivity to white matter FMRI activation increases with field strength.

Functional magnetic resonance imaging (fMRI) activation in white matter is controversial. Given that many of the studies that report fMRI activation in white matter used high field MRI systems, we investigated the field strength dependence of sensitivity to white matter fMRI activation. In addition,...

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Autores principales:	Erin L Mazerolle, Jodie R Gawryluk, Kim N H Dillen, Steven A Patterson, Kirk W Feindel, Steven D Beyea, M Tynan R Stevens, Aaron J Newman, Matthias H Schmidt, Ryan C N D'Arcy
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/310826c20cd54b2ca0ea362a396e1a6d
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id	oai:doaj.org-article:310826c20cd54b2ca0ea362a396e1a6d
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spelling	oai:doaj.org-article:310826c20cd54b2ca0ea362a396e1a6d2021-11-18T07:55:01ZSensitivity to white matter FMRI activation increases with field strength.1932-620310.1371/journal.pone.0058130https://doaj.org/article/310826c20cd54b2ca0ea362a396e1a6d2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23483983/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Functional magnetic resonance imaging (fMRI) activation in white matter is controversial. Given that many of the studies that report fMRI activation in white matter used high field MRI systems, we investigated the field strength dependence of sensitivity to white matter fMRI activation. In addition, we evaluated the temporal signal to noise ratio (tSNR) of the different tissue types as a function of field strength. Data were acquired during a motor task (finger tapping) at 1.5 T and 4 T. Group and individual level activation results were considered in both the sensorimotor cortex and the posterior limb of the internal capsule. We found that sensitivity increases associated with field strength were greater for white matter than gray matter. The analysis of tSNR suggested that white matter might be less susceptible to increases in physiological noise related to increased field strength. We therefore conclude that high field MRI may be particularly advantageous for fMRI studies aimed at investigating activation in both gray and white matter.Erin L MazerolleJodie R GawrylukKim N H DillenSteven A PattersonKirk W FeindelSteven D BeyeaM Tynan R StevensAaron J NewmanMatthias H SchmidtRyan C N D'ArcyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e58130 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Erin L Mazerolle Jodie R Gawryluk Kim N H Dillen Steven A Patterson Kirk W Feindel Steven D Beyea M Tynan R Stevens Aaron J Newman Matthias H Schmidt Ryan C N D'Arcy Sensitivity to white matter FMRI activation increases with field strength.
description	Functional magnetic resonance imaging (fMRI) activation in white matter is controversial. Given that many of the studies that report fMRI activation in white matter used high field MRI systems, we investigated the field strength dependence of sensitivity to white matter fMRI activation. In addition, we evaluated the temporal signal to noise ratio (tSNR) of the different tissue types as a function of field strength. Data were acquired during a motor task (finger tapping) at 1.5 T and 4 T. Group and individual level activation results were considered in both the sensorimotor cortex and the posterior limb of the internal capsule. We found that sensitivity increases associated with field strength were greater for white matter than gray matter. The analysis of tSNR suggested that white matter might be less susceptible to increases in physiological noise related to increased field strength. We therefore conclude that high field MRI may be particularly advantageous for fMRI studies aimed at investigating activation in both gray and white matter.
format	article
author	Erin L Mazerolle Jodie R Gawryluk Kim N H Dillen Steven A Patterson Kirk W Feindel Steven D Beyea M Tynan R Stevens Aaron J Newman Matthias H Schmidt Ryan C N D'Arcy
author_facet	Erin L Mazerolle Jodie R Gawryluk Kim N H Dillen Steven A Patterson Kirk W Feindel Steven D Beyea M Tynan R Stevens Aaron J Newman Matthias H Schmidt Ryan C N D'Arcy
author_sort	Erin L Mazerolle
title	Sensitivity to white matter FMRI activation increases with field strength.
title_short	Sensitivity to white matter FMRI activation increases with field strength.
title_full	Sensitivity to white matter FMRI activation increases with field strength.
title_fullStr	Sensitivity to white matter FMRI activation increases with field strength.
title_full_unstemmed	Sensitivity to white matter FMRI activation increases with field strength.
title_sort	sensitivity to white matter fmri activation increases with field strength.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/310826c20cd54b2ca0ea362a396e1a6d
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_version_	1718422720154173440

Sensitivity to white matter FMRI activation increases with field strength.

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