Localization and expression of the Mas-related G-protein coupled receptor member D (MrgD) in the mouse brain

Numerous studies in the last decades have provided evidence for the existence of a local renin-angiotensin system (RAS) in the central nervous system (CNS). Widespread distribution of the different RAS components in the brain demonstrates the pleiotropic role of this system in the structure and func...

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Autores principales:	Javad Hami, Viola von Bohlen und Halbach, Anja Tetzner, Thomas Walther, Oliver von Bohlen und Halbach
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	MrgD Brain Mouse Science (General) Q1-390 Social sciences (General) H1-99
Acceso en línea:	https://doaj.org/article/3108f5bd468c4bf79204079909a8d25f
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spelling	oai:doaj.org-article:3108f5bd468c4bf79204079909a8d25f2021-12-02T05:03:14ZLocalization and expression of the Mas-related G-protein coupled receptor member D (MrgD) in the mouse brain2405-844010.1016/j.heliyon.2021.e08440https://doaj.org/article/3108f5bd468c4bf79204079909a8d25f2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2405844021025433https://doaj.org/toc/2405-8440Numerous studies in the last decades have provided evidence for the existence of a local renin-angiotensin system (RAS) in the central nervous system (CNS). Widespread distribution of the different RAS components in the brain demonstrates the pleiotropic role of this system in the structure and function of CNS. With the advent of new molecular techniques, a novel receptor has been identified within the beneficial arm of the RAS, the Mas-related G-protein coupled receptor D (MrgD), which can be stimulated by two heptapeptides, Ala1-(Ang-(1-7), also named alamandine, and Ang-(1-7). However, the biological and physiological relevance of this interaction remains obscure. Since several recent studies hinted at a role of MrgD in the CNS, we determined the distribution pattern of MrgD receptors in the adult mouse brain by using a genetic mouse model with tracers of MrgD expression. MrgD-positive cells could be identified in some forebrain areas, including cortex, hippocampus, amygdala, hypothalamus, habenular nuclei, striatum and pallidum, as well as in some mid-brain nuclei in a region-specific manner. The specific localization of MrgD in the reward- and limbic-related areas can hint at a role of MrgD in processes such as pain perception/modulation, synaptic plasticity, learning, memory and cognition.Javad HamiViola von Bohlen und HalbachAnja TetznerThomas WaltherOliver von Bohlen und HalbachElsevierarticleMrgDBrainMouseScience (General)Q1-390Social sciences (General)H1-99ENHeliyon, Vol 7, Iss 11, Pp e08440- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	MrgD Brain Mouse Science (General) Q1-390 Social sciences (General) H1-99
spellingShingle	MrgD Brain Mouse Science (General) Q1-390 Social sciences (General) H1-99 Javad Hami Viola von Bohlen und Halbach Anja Tetzner Thomas Walther Oliver von Bohlen und Halbach Localization and expression of the Mas-related G-protein coupled receptor member D (MrgD) in the mouse brain
description	Numerous studies in the last decades have provided evidence for the existence of a local renin-angiotensin system (RAS) in the central nervous system (CNS). Widespread distribution of the different RAS components in the brain demonstrates the pleiotropic role of this system in the structure and function of CNS. With the advent of new molecular techniques, a novel receptor has been identified within the beneficial arm of the RAS, the Mas-related G-protein coupled receptor D (MrgD), which can be stimulated by two heptapeptides, Ala1-(Ang-(1-7), also named alamandine, and Ang-(1-7). However, the biological and physiological relevance of this interaction remains obscure. Since several recent studies hinted at a role of MrgD in the CNS, we determined the distribution pattern of MrgD receptors in the adult mouse brain by using a genetic mouse model with tracers of MrgD expression. MrgD-positive cells could be identified in some forebrain areas, including cortex, hippocampus, amygdala, hypothalamus, habenular nuclei, striatum and pallidum, as well as in some mid-brain nuclei in a region-specific manner. The specific localization of MrgD in the reward- and limbic-related areas can hint at a role of MrgD in processes such as pain perception/modulation, synaptic plasticity, learning, memory and cognition.
format	article
author	Javad Hami Viola von Bohlen und Halbach Anja Tetzner Thomas Walther Oliver von Bohlen und Halbach
author_facet	Javad Hami Viola von Bohlen und Halbach Anja Tetzner Thomas Walther Oliver von Bohlen und Halbach
author_sort	Javad Hami
title	Localization and expression of the Mas-related G-protein coupled receptor member D (MrgD) in the mouse brain
title_short	Localization and expression of the Mas-related G-protein coupled receptor member D (MrgD) in the mouse brain
title_full	Localization and expression of the Mas-related G-protein coupled receptor member D (MrgD) in the mouse brain
title_fullStr	Localization and expression of the Mas-related G-protein coupled receptor member D (MrgD) in the mouse brain
title_full_unstemmed	Localization and expression of the Mas-related G-protein coupled receptor member D (MrgD) in the mouse brain
title_sort	localization and expression of the mas-related g-protein coupled receptor member d (mrgd) in the mouse brain
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/3108f5bd468c4bf79204079909a8d25f
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Localization and expression of the Mas-related G-protein coupled receptor member D (MrgD) in the mouse brain

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