Longitudinal study of the scalp microbiome suggests coconut oil to enrich healthy scalp commensals

Abstract Dandruff is a recurrent chronic scalp disorder, affecting majority of the population worldwide. Recently a metagenomic study of the Indian scalp microbiome described an imperative role of bacterial commensals in providing essential vitamins and amino acids to the scalp. Coconut oil and its...

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Autores principales:	Rituja Saxena, Parul Mittal, Cecile Clavaud, Darshan B. Dhakan, Nita Roy, Lionel Breton, Namita Misra, Vineet K. Sharma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/310be7ad74a24863b260121cae07c0a3
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spelling	oai:doaj.org-article:310be7ad74a24863b260121cae07c0a32021-12-02T18:17:41ZLongitudinal study of the scalp microbiome suggests coconut oil to enrich healthy scalp commensals10.1038/s41598-021-86454-12045-2322https://doaj.org/article/310be7ad74a24863b260121cae07c0a32021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86454-1https://doaj.org/toc/2045-2322Abstract Dandruff is a recurrent chronic scalp disorder, affecting majority of the population worldwide. Recently a metagenomic study of the Indian scalp microbiome described an imperative role of bacterial commensals in providing essential vitamins and amino acids to the scalp. Coconut oil and its formulations are commonly applied on the scalp in several parts of the world to maintain scalp health. Thus, in this study we examined the effect of topical application of coconut oil on the scalp microbiome (bacterial and fungal) at the taxonomic and functional levels and their correlation with scalp physiological parameters. A 16-weeks-long time-course study was performed including 12-weeks of treatment and 4-weeks of relapse phase on a cohort of 140 (70 healthy and 70 dandruff) Indian women, resulting in ~ 900 metagenomic samples. After the treatment phase, an increase in the abundance of Cutibacterium acnes and Malassezia globosa in dandruff scalp was observed, which were negatively correlated to dandruff parameters. At the functional level, an enrichment of healthy scalp-related bacterial pathways, such as biotin metabolism and decrease in the fungal pathogenesis pathways was observed. The study provides novel insights on the effect of coconut oil in maintaining a healthy scalp and in modulating the scalp microbiome.Rituja SaxenaParul MittalCecile ClavaudDarshan B. DhakanNita RoyLionel BretonNamita MisraVineet K. SharmaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rituja Saxena Parul Mittal Cecile Clavaud Darshan B. Dhakan Nita Roy Lionel Breton Namita Misra Vineet K. Sharma Longitudinal study of the scalp microbiome suggests coconut oil to enrich healthy scalp commensals
description	Abstract Dandruff is a recurrent chronic scalp disorder, affecting majority of the population worldwide. Recently a metagenomic study of the Indian scalp microbiome described an imperative role of bacterial commensals in providing essential vitamins and amino acids to the scalp. Coconut oil and its formulations are commonly applied on the scalp in several parts of the world to maintain scalp health. Thus, in this study we examined the effect of topical application of coconut oil on the scalp microbiome (bacterial and fungal) at the taxonomic and functional levels and their correlation with scalp physiological parameters. A 16-weeks-long time-course study was performed including 12-weeks of treatment and 4-weeks of relapse phase on a cohort of 140 (70 healthy and 70 dandruff) Indian women, resulting in ~ 900 metagenomic samples. After the treatment phase, an increase in the abundance of Cutibacterium acnes and Malassezia globosa in dandruff scalp was observed, which were negatively correlated to dandruff parameters. At the functional level, an enrichment of healthy scalp-related bacterial pathways, such as biotin metabolism and decrease in the fungal pathogenesis pathways was observed. The study provides novel insights on the effect of coconut oil in maintaining a healthy scalp and in modulating the scalp microbiome.
format	article
author	Rituja Saxena Parul Mittal Cecile Clavaud Darshan B. Dhakan Nita Roy Lionel Breton Namita Misra Vineet K. Sharma
author_facet	Rituja Saxena Parul Mittal Cecile Clavaud Darshan B. Dhakan Nita Roy Lionel Breton Namita Misra Vineet K. Sharma
author_sort	Rituja Saxena
title	Longitudinal study of the scalp microbiome suggests coconut oil to enrich healthy scalp commensals
title_short	Longitudinal study of the scalp microbiome suggests coconut oil to enrich healthy scalp commensals
title_full	Longitudinal study of the scalp microbiome suggests coconut oil to enrich healthy scalp commensals
title_fullStr	Longitudinal study of the scalp microbiome suggests coconut oil to enrich healthy scalp commensals
title_full_unstemmed	Longitudinal study of the scalp microbiome suggests coconut oil to enrich healthy scalp commensals
title_sort	longitudinal study of the scalp microbiome suggests coconut oil to enrich healthy scalp commensals
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/310be7ad74a24863b260121cae07c0a3
work_keys_str_mv	AT ritujasaxena longitudinalstudyofthescalpmicrobiomesuggestscoconutoiltoenrichhealthyscalpcommensals AT parulmittal longitudinalstudyofthescalpmicrobiomesuggestscoconutoiltoenrichhealthyscalpcommensals AT cecileclavaud longitudinalstudyofthescalpmicrobiomesuggestscoconutoiltoenrichhealthyscalpcommensals AT darshanbdhakan longitudinalstudyofthescalpmicrobiomesuggestscoconutoiltoenrichhealthyscalpcommensals AT nitaroy longitudinalstudyofthescalpmicrobiomesuggestscoconutoiltoenrichhealthyscalpcommensals AT lionelbreton longitudinalstudyofthescalpmicrobiomesuggestscoconutoiltoenrichhealthyscalpcommensals AT namitamisra longitudinalstudyofthescalpmicrobiomesuggestscoconutoiltoenrichhealthyscalpcommensals AT vineetksharma longitudinalstudyofthescalpmicrobiomesuggestscoconutoiltoenrichhealthyscalpcommensals
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Longitudinal study of the scalp microbiome suggests coconut oil to enrich healthy scalp commensals

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