Abnormal prefrontal brain activation during a verbal fluency task in bipolar disorder patients with psychotic symptoms using multichannel NIRS

Jing-Jing Sun,1,2 Xiao-Min Liu,2 Chen-Yu Shen,2 Kun Feng,1,2 Po-Zi Liu2 1School of Clinical Medicine, Medicine Institute, Tsinghua University, Beijing, China; 2Yu Quan Hospital, Clinical Neuroscience Institute, Tsinghua University, Beijing, China Purpose: Bipolar disorder (BD) patients with psycho...

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Autores principales:	Sun JJ, Liu XM, Shen CY, Feng K, Liu PZ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Bipolar disorder depressive psychotic symptoms near-infrared spectroscopy (NIRS) verbal ﬂuency task Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/3110854e6d1a43a88eeac694966d7e70
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spelling	oai:doaj.org-article:3110854e6d1a43a88eeac694966d7e702021-12-02T09:23:37ZAbnormal prefrontal brain activation during a verbal fluency task in bipolar disorder patients with psychotic symptoms using multichannel NIRS1178-2021https://doaj.org/article/3110854e6d1a43a88eeac694966d7e702018-11-01T00:00:00Zhttps://www.dovepress.com/abnormal-prefrontal-brain-activation-during-a-verbal-fluency-task-in-b-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Jing-Jing Sun,1,2 Xiao-Min Liu,2 Chen-Yu Shen,2 Kun Feng,1,2 Po-Zi Liu2 1School of Clinical Medicine, Medicine Institute, Tsinghua University, Beijing, China; 2Yu Quan Hospital, Clinical Neuroscience Institute, Tsinghua University, Beijing, China Purpose: Bipolar disorder (BD) patients with psychotic symptoms (BDp) worsens prognosis and decreases rates of recovery. The study investigated cognitive performance and brain function between BD patients in depressive episode with and without psychotic symptoms to find potential neurobiological markers associated with psychotic features of BD patients in depressive episode. Patients and methods: Thirty-one patients without psychotic symptoms and 29 patients with psychotic symptoms diagnosed with bipolar I disorder with a current depressive episode were included in the present study. The neural function of prefrontal cortex (PFC) and cognitive performance among BDp, BD patients without psychotic symptoms, and 23 healthy controls (HC) were examined using near-infrared spectroscopy during verbal fluency task (VFT). Results: 1) Both the BD groups exhibited significantly worse performance of VFT and lower activation of oxygenated hemoglobin (oxy-Hb) changes in the bilateral ventrolateral PFC compared with the HC group. 2) Within the BD group, VFT performance was not significantly different. 3) The prefrontal activation of oxy-Hb changes in the BDp patients was significantly lower than that in the BD patients without psychotic symptoms in the right dorsolateral PFC. 4) Activation of oxy-Hb changes in right dorsolateral PFC was negatively correlated with the severity of psychotic symptoms in BDp patients. Conclusion: The prefrontal function differs between BD patients in depressive episode with or without psychotic symptoms measured with near-infrared spectroscopy. Keywords: bipolar disorder, depressive, psychotic symptoms, near-infrared spectroscopy, verbal fluency taskSun JJLiu XMShen CYFeng KLiu PZDove Medical PressarticleBipolar disorderdepressivepsychotic symptomsnear-infrared spectroscopy (NIRS)verbal ﬂuency taskNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 3081-3090 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bipolar disorder depressive psychotic symptoms near-infrared spectroscopy (NIRS) verbal ﬂuency task Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Bipolar disorder depressive psychotic symptoms near-infrared spectroscopy (NIRS) verbal ﬂuency task Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Sun JJ Liu XM Shen CY Feng K Liu PZ Abnormal prefrontal brain activation during a verbal fluency task in bipolar disorder patients with psychotic symptoms using multichannel NIRS
description	Jing-Jing Sun,1,2 Xiao-Min Liu,2 Chen-Yu Shen,2 Kun Feng,1,2 Po-Zi Liu2 1School of Clinical Medicine, Medicine Institute, Tsinghua University, Beijing, China; 2Yu Quan Hospital, Clinical Neuroscience Institute, Tsinghua University, Beijing, China Purpose: Bipolar disorder (BD) patients with psychotic symptoms (BDp) worsens prognosis and decreases rates of recovery. The study investigated cognitive performance and brain function between BD patients in depressive episode with and without psychotic symptoms to find potential neurobiological markers associated with psychotic features of BD patients in depressive episode. Patients and methods: Thirty-one patients without psychotic symptoms and 29 patients with psychotic symptoms diagnosed with bipolar I disorder with a current depressive episode were included in the present study. The neural function of prefrontal cortex (PFC) and cognitive performance among BDp, BD patients without psychotic symptoms, and 23 healthy controls (HC) were examined using near-infrared spectroscopy during verbal fluency task (VFT). Results: 1) Both the BD groups exhibited significantly worse performance of VFT and lower activation of oxygenated hemoglobin (oxy-Hb) changes in the bilateral ventrolateral PFC compared with the HC group. 2) Within the BD group, VFT performance was not significantly different. 3) The prefrontal activation of oxy-Hb changes in the BDp patients was significantly lower than that in the BD patients without psychotic symptoms in the right dorsolateral PFC. 4) Activation of oxy-Hb changes in right dorsolateral PFC was negatively correlated with the severity of psychotic symptoms in BDp patients. Conclusion: The prefrontal function differs between BD patients in depressive episode with or without psychotic symptoms measured with near-infrared spectroscopy. Keywords: bipolar disorder, depressive, psychotic symptoms, near-infrared spectroscopy, verbal fluency task
format	article
author	Sun JJ Liu XM Shen CY Feng K Liu PZ
author_facet	Sun JJ Liu XM Shen CY Feng K Liu PZ
author_sort	Sun JJ
title	Abnormal prefrontal brain activation during a verbal fluency task in bipolar disorder patients with psychotic symptoms using multichannel NIRS
title_short	Abnormal prefrontal brain activation during a verbal fluency task in bipolar disorder patients with psychotic symptoms using multichannel NIRS
title_full	Abnormal prefrontal brain activation during a verbal fluency task in bipolar disorder patients with psychotic symptoms using multichannel NIRS
title_fullStr	Abnormal prefrontal brain activation during a verbal fluency task in bipolar disorder patients with psychotic symptoms using multichannel NIRS
title_full_unstemmed	Abnormal prefrontal brain activation during a verbal fluency task in bipolar disorder patients with psychotic symptoms using multichannel NIRS
title_sort	abnormal prefrontal brain activation during a verbal fluency task in bipolar disorder patients with psychotic symptoms using multichannel nirs
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/3110854e6d1a43a88eeac694966d7e70
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_version_	1718398112903462912

Abnormal prefrontal brain activation during a verbal fluency task in bipolar disorder patients with psychotic symptoms using multichannel NIRS

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