DNA double strand breaks but not interstrand crosslinks prevent progress through meiosis in fully grown mouse oocytes.

DNA double strand breaks but not interstrand crosslinks prevent progress through meiosis in fully grown mouse oocytes.

There is some interest in how mammalian oocytes respond to different types of DNA damage because of the increasing expectation of fertility preservation in women undergoing chemotherapy. Double strand breaks (DSBs) induced by ionizing radiation and agents such as neocarzinostatin (NCS), and interstr...

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Autores principales: Wai Shan Yuen, Julie A Merriman, Moira K O'Bryan, Keith T Jones
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/3111bf98757e4f12b0474ea4fe5d8f61
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