Factors Affecting the Long-Term Survival of Kidney Transplanta-tion in Northeastern of Iran between 2000 and 2015

Background: Graft and patient survival are of great importance after transplantation. This study aimed to determine the long-term survival rate of kidney transplantation and its effective factors among transplanted patients in Mashhad transplantation centers in northeastern Iran. Methods: Overal...

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Autores principales:	Rasoul Alimi, Maryam Hami, Monavar Afzalaghaee, Fatemeh Nazemian, Mahmood Mahmoodi, Mehdi Yaseri, Hojjat Zeraati
Formato:	article
Lenguaje:	EN
Publicado:	Tehran University of Medical Sciences 2021
Materias:	Kidney transplantation Graft survival Proportional hazards models Kidney failure Chronic; Survival rate Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/3112bf113a964f85a7d4f0dbe8cf8e48
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spelling	oai:doaj.org-article:3112bf113a964f85a7d4f0dbe8cf8e482021-12-02T18:22:08ZFactors Affecting the Long-Term Survival of Kidney Transplanta-tion in Northeastern of Iran between 2000 and 201510.18502/ijph.v50i10.75082251-60852251-6093https://doaj.org/article/3112bf113a964f85a7d4f0dbe8cf8e482021-10-01T00:00:00Zhttps://ijph.tums.ac.ir/index.php/ijph/article/view/19536https://doaj.org/toc/2251-6085https://doaj.org/toc/2251-6093 Background: Graft and patient survival are of great importance after transplantation. This study aimed to determine the long-term survival rate of kidney transplantation and its effective factors among transplanted patients in Mashhad transplantation centers in northeastern Iran. Methods: Overall, 618 kidney transplant recipients were examined in different transplantation centers during the years from 2000 to 2015 in a historical cohort study. The Kaplan-Meier method and the Log-rank test were used to calculate the survival rate of the kidney transplant, and to check the difference between survival curves respectively. Modeling of effective factors in survival rate was performed using Cox regression model. Results: Overall, 1, 3, 5, 7, 10, and 15-year survival rate of kidney transplantation were 99%, 98%, 97%, 93%, 88 and 70% respectively. The adjusted hazard ratio indicated that variables such as recipient age >40 yr [HR=0.22, 95% CI=(0.071,0.691)], serum creatinine after transplantation >1.6 Mg/dl [HR=3.03, 95% CI=(1.284,7.125)], history of hypertension [HR=6.70, 95% CI=(2.746,16.348)], and BMI [HR (normal weight versus underweight)=0.26, 95% CI=(0.088,0.761), HR (over weight versus underweight)=0.13,95% CI=(0.038,0.442)] were significant factors on kidney transplant survival rate. Conclusion: The short-term transplant survival rate was good in transplant patients. What's more, through a consideration of variables such as age, creatinine serum after transplantation, history hypertension and body mass index, as well as proper planning to control their effect, it is possible to improve the long-term graft survival rate. Rasoul AlimiMaryam HamiMonavar AfzalaghaeeFatemeh NazemianMahmood MahmoodiMehdi YaseriHojjat ZeraatiTehran University of Medical SciencesarticleKidney transplantationGraft survivalProportional hazards modelsKidney failureChronic; Survival ratePublic aspects of medicineRA1-1270ENIranian Journal of Public Health, Vol 50, Iss 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Kidney transplantation Graft survival Proportional hazards models Kidney failure Chronic; Survival rate Public aspects of medicine RA1-1270
spellingShingle	Kidney transplantation Graft survival Proportional hazards models Kidney failure Chronic; Survival rate Public aspects of medicine RA1-1270 Rasoul Alimi Maryam Hami Monavar Afzalaghaee Fatemeh Nazemian Mahmood Mahmoodi Mehdi Yaseri Hojjat Zeraati Factors Affecting the Long-Term Survival of Kidney Transplanta-tion in Northeastern of Iran between 2000 and 2015
description	Background: Graft and patient survival are of great importance after transplantation. This study aimed to determine the long-term survival rate of kidney transplantation and its effective factors among transplanted patients in Mashhad transplantation centers in northeastern Iran. Methods: Overall, 618 kidney transplant recipients were examined in different transplantation centers during the years from 2000 to 2015 in a historical cohort study. The Kaplan-Meier method and the Log-rank test were used to calculate the survival rate of the kidney transplant, and to check the difference between survival curves respectively. Modeling of effective factors in survival rate was performed using Cox regression model. Results: Overall, 1, 3, 5, 7, 10, and 15-year survival rate of kidney transplantation were 99%, 98%, 97%, 93%, 88 and 70% respectively. The adjusted hazard ratio indicated that variables such as recipient age >40 yr [HR=0.22, 95% CI=(0.071,0.691)], serum creatinine after transplantation >1.6 Mg/dl [HR=3.03, 95% CI=(1.284,7.125)], history of hypertension [HR=6.70, 95% CI=(2.746,16.348)], and BMI [HR (normal weight versus underweight)=0.26, 95% CI=(0.088,0.761), HR (over weight versus underweight)=0.13,95% CI=(0.038,0.442)] were significant factors on kidney transplant survival rate. Conclusion: The short-term transplant survival rate was good in transplant patients. What's more, through a consideration of variables such as age, creatinine serum after transplantation, history hypertension and body mass index, as well as proper planning to control their effect, it is possible to improve the long-term graft survival rate.
format	article
author	Rasoul Alimi Maryam Hami Monavar Afzalaghaee Fatemeh Nazemian Mahmood Mahmoodi Mehdi Yaseri Hojjat Zeraati
author_facet	Rasoul Alimi Maryam Hami Monavar Afzalaghaee Fatemeh Nazemian Mahmood Mahmoodi Mehdi Yaseri Hojjat Zeraati
author_sort	Rasoul Alimi
title	Factors Affecting the Long-Term Survival of Kidney Transplanta-tion in Northeastern of Iran between 2000 and 2015
title_short	Factors Affecting the Long-Term Survival of Kidney Transplanta-tion in Northeastern of Iran between 2000 and 2015
title_full	Factors Affecting the Long-Term Survival of Kidney Transplanta-tion in Northeastern of Iran between 2000 and 2015
title_fullStr	Factors Affecting the Long-Term Survival of Kidney Transplanta-tion in Northeastern of Iran between 2000 and 2015
title_full_unstemmed	Factors Affecting the Long-Term Survival of Kidney Transplanta-tion in Northeastern of Iran between 2000 and 2015
title_sort	factors affecting the long-term survival of kidney transplanta-tion in northeastern of iran between 2000 and 2015
publisher	Tehran University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/3112bf113a964f85a7d4f0dbe8cf8e48
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Factors Affecting the Long-Term Survival of Kidney Transplanta-tion in Northeastern of Iran between 2000 and 2015

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