Insights from Clonal Expansion and HIV Persistence in Perinatal Infections

ABSTRACT The latent HIV reservoir forms early in the course of infection and is maintained for life despite effective antiretroviral treatment (ART), including early treatment. Perinatal HIV infection presents a unique opportunity to limit seeding of the reservoir through early ART. However, a great...

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Autores principales:	Adit Dhummakupt, Deborah Persaud
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	human immunodeficiency virus perinatal infections clonal expansion latent reservoir Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/3113ca5c608a44f593f50e56723e67a3
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spelling	oai:doaj.org-article:3113ca5c608a44f593f50e56723e67a32021-11-10T18:37:52ZInsights from Clonal Expansion and HIV Persistence in Perinatal Infections10.1128/mBio.00983-212150-7511https://doaj.org/article/3113ca5c608a44f593f50e56723e67a32021-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00983-21https://doaj.org/toc/2150-7511ABSTRACT The latent HIV reservoir forms early in the course of infection and is maintained for life despite effective antiretroviral treatment (ART), including early treatment. Perinatal HIV infection presents a unique opportunity to limit seeding of the reservoir through early ART. However, a greater understanding of the persistence of the integrated proviruses is needed for targeting the residual proviruses that form barriers to cure. A study was performed by Bale and Katusiime et al. (M. J. Bale, M. G. Katusiime, D. Wells, X. Wu, et al., mBio 12:e00568-21, 2021, https://doi.org/10.1128/mBio.00568-21) using in-depth integration site analysis in 11 children before ART and after up to nine years of ART. They have identified early development of long-lived proviruses, although the replication competence is unknown. A small fraction of cells bearing integrated proviruses clonally expand early during infection and persist. Integration in the oncogenes STAT5B and BACH2 were also found; these findings confirm the early development of clonal proliferation in perinatal HIV infection despite early effective ART, with a propensity for oncogenes.Adit DhummakuptDeborah PersaudAmerican Society for Microbiologyarticlehuman immunodeficiency virusperinatal infectionsclonal expansionlatent reservoirMicrobiologyQR1-502ENmBio, Vol 12, Iss 4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	human immunodeficiency virus perinatal infections clonal expansion latent reservoir Microbiology QR1-502
spellingShingle	human immunodeficiency virus perinatal infections clonal expansion latent reservoir Microbiology QR1-502 Adit Dhummakupt Deborah Persaud Insights from Clonal Expansion and HIV Persistence in Perinatal Infections
description	ABSTRACT The latent HIV reservoir forms early in the course of infection and is maintained for life despite effective antiretroviral treatment (ART), including early treatment. Perinatal HIV infection presents a unique opportunity to limit seeding of the reservoir through early ART. However, a greater understanding of the persistence of the integrated proviruses is needed for targeting the residual proviruses that form barriers to cure. A study was performed by Bale and Katusiime et al. (M. J. Bale, M. G. Katusiime, D. Wells, X. Wu, et al., mBio 12:e00568-21, 2021, https://doi.org/10.1128/mBio.00568-21) using in-depth integration site analysis in 11 children before ART and after up to nine years of ART. They have identified early development of long-lived proviruses, although the replication competence is unknown. A small fraction of cells bearing integrated proviruses clonally expand early during infection and persist. Integration in the oncogenes STAT5B and BACH2 were also found; these findings confirm the early development of clonal proliferation in perinatal HIV infection despite early effective ART, with a propensity for oncogenes.
format	article
author	Adit Dhummakupt Deborah Persaud
author_facet	Adit Dhummakupt Deborah Persaud
author_sort	Adit Dhummakupt
title	Insights from Clonal Expansion and HIV Persistence in Perinatal Infections
title_short	Insights from Clonal Expansion and HIV Persistence in Perinatal Infections
title_full	Insights from Clonal Expansion and HIV Persistence in Perinatal Infections
title_fullStr	Insights from Clonal Expansion and HIV Persistence in Perinatal Infections
title_full_unstemmed	Insights from Clonal Expansion and HIV Persistence in Perinatal Infections
title_sort	insights from clonal expansion and hiv persistence in perinatal infections
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/3113ca5c608a44f593f50e56723e67a3
work_keys_str_mv	AT aditdhummakupt insightsfromclonalexpansionandhivpersistenceinperinatalinfections AT deborahpersaud insightsfromclonalexpansionandhivpersistenceinperinatalinfections
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Insights from Clonal Expansion and HIV Persistence in Perinatal Infections

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