Evidence of a dysregulated vitamin D endocrine system in SARS-CoV-2 infected patient’s lung cells

Abstract Although a defective vitamin D endocrine system has been widely suspected to be associated in SARS-CoV-2 pathobiology, the status of the vitamin D endocrine system and vitamin D-modulated genes in lung cells of patients infected with SARS-CoV-2 remains unknown. To understand the significanc...

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Autores principales:	Bijesh George, Revikumar Amjesh, Aswathy Mary Paul, T. R. Santhoshkumar, Madhavan Radhakrishna Pillai, Rakesh Kumar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3114f67896354fdcb40d9447f1016a17
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spelling	oai:doaj.org-article:3114f67896354fdcb40d9447f1016a172021-12-02T17:32:56ZEvidence of a dysregulated vitamin D endocrine system in SARS-CoV-2 infected patient’s lung cells10.1038/s41598-021-87703-z2045-2322https://doaj.org/article/3114f67896354fdcb40d9447f1016a172021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87703-zhttps://doaj.org/toc/2045-2322Abstract Although a defective vitamin D endocrine system has been widely suspected to be associated in SARS-CoV-2 pathobiology, the status of the vitamin D endocrine system and vitamin D-modulated genes in lung cells of patients infected with SARS-CoV-2 remains unknown. To understand the significance of the vitamin D endocrine system in SARS-CoV-2 pathobiology, computational approaches were applied to transcriptomic datasets from bronchoalveolar lavage fluid (BALF) cells of such patients or healthy individuals. Levels of vitamin D receptor, retinoid X receptor, and CYP27A1 in BALF cells of patients infected with SARS-CoV-2 were found to be reduced. Additionally, 107 differentially expressed, predominantly downregulated genes, as potentially modulated by vitamin D endocrine system, were identified in transcriptomic datasets from patient’s cells. Further analysis of differentially expressed genes provided eight novel genes with a conserved motif with vitamin D-responsive elements, implying the role of both direct and indirect mechanisms of gene expression by the dysregulated vitamin D endocrine system in SARS-CoV-2-infected cells. Protein–protein interaction network of differentially expressed vitamin D-modulated genes were enriched in the immune system, NF-κB/cytokine signaling, and cell cycle regulation as top predicted pathways that might be affected in the cells of such patients. In brief, the results presented here povide computational evidence to implicate a dysregulated vitamin D endocrine system in the pathobiology of SARS-CoV-2 infection.Bijesh GeorgeRevikumar AmjeshAswathy Mary PaulT. R. SanthoshkumarMadhavan Radhakrishna PillaiRakesh KumarNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bijesh George Revikumar Amjesh Aswathy Mary Paul T. R. Santhoshkumar Madhavan Radhakrishna Pillai Rakesh Kumar Evidence of a dysregulated vitamin D endocrine system in SARS-CoV-2 infected patient’s lung cells
description	Abstract Although a defective vitamin D endocrine system has been widely suspected to be associated in SARS-CoV-2 pathobiology, the status of the vitamin D endocrine system and vitamin D-modulated genes in lung cells of patients infected with SARS-CoV-2 remains unknown. To understand the significance of the vitamin D endocrine system in SARS-CoV-2 pathobiology, computational approaches were applied to transcriptomic datasets from bronchoalveolar lavage fluid (BALF) cells of such patients or healthy individuals. Levels of vitamin D receptor, retinoid X receptor, and CYP27A1 in BALF cells of patients infected with SARS-CoV-2 were found to be reduced. Additionally, 107 differentially expressed, predominantly downregulated genes, as potentially modulated by vitamin D endocrine system, were identified in transcriptomic datasets from patient’s cells. Further analysis of differentially expressed genes provided eight novel genes with a conserved motif with vitamin D-responsive elements, implying the role of both direct and indirect mechanisms of gene expression by the dysregulated vitamin D endocrine system in SARS-CoV-2-infected cells. Protein–protein interaction network of differentially expressed vitamin D-modulated genes were enriched in the immune system, NF-κB/cytokine signaling, and cell cycle regulation as top predicted pathways that might be affected in the cells of such patients. In brief, the results presented here povide computational evidence to implicate a dysregulated vitamin D endocrine system in the pathobiology of SARS-CoV-2 infection.
format	article
author	Bijesh George Revikumar Amjesh Aswathy Mary Paul T. R. Santhoshkumar Madhavan Radhakrishna Pillai Rakesh Kumar
author_facet	Bijesh George Revikumar Amjesh Aswathy Mary Paul T. R. Santhoshkumar Madhavan Radhakrishna Pillai Rakesh Kumar
author_sort	Bijesh George
title	Evidence of a dysregulated vitamin D endocrine system in SARS-CoV-2 infected patient’s lung cells
title_short	Evidence of a dysregulated vitamin D endocrine system in SARS-CoV-2 infected patient’s lung cells
title_full	Evidence of a dysregulated vitamin D endocrine system in SARS-CoV-2 infected patient’s lung cells
title_fullStr	Evidence of a dysregulated vitamin D endocrine system in SARS-CoV-2 infected patient’s lung cells
title_full_unstemmed	Evidence of a dysregulated vitamin D endocrine system in SARS-CoV-2 infected patient’s lung cells
title_sort	evidence of a dysregulated vitamin d endocrine system in sars-cov-2 infected patient’s lung cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3114f67896354fdcb40d9447f1016a17
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Evidence of a dysregulated vitamin D endocrine system in SARS-CoV-2 infected patient’s lung cells

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