Introduction of Two Prolines and Removal of the Polybasic Cleavage Site Lead to Higher Efficacy of a Recombinant Spike-Based SARS-CoV-2 Vaccine in the Mouse Model

Introduction of Two Prolines and Removal of the Polybasic Cleavage Site Lead to Higher Efficacy of a Recombinant Spike-Based SARS-CoV-2 Vaccine in the Mouse Model

ABSTRACT The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been identified as the prime target for vaccine development. The spike protein mediates both binding to host cells and membrane fusion and is also so far the only known viral target of neutralizing antibod...

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Autores principales: Fatima Amanat, Shirin Strohmeier, Raveen Rathnasinghe, Michael Schotsaert, Lynda Coughlan, Adolfo García-Sastre, Florian Krammer
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2021
Materias:
COVID-19
SARS-CoV-2
spike
vaccine
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/3115dd1525384801b253562bd43d4a68
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