Gender Differences in the Clinical and Polysomnographic Characteristics Among Australian Aboriginal Patients with Obstructive Sleep Apnea

Sumit Mehra,1,2 Ram H Ghimire,1 Joy J Mingi,3,4 Monica Hatch,1 Himanshu Garg,1 Robert Adams,5 Subash S Heraganahally1,3 1Department of Respiratory and Sleep Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia; 2Department of Respiratory and Sleep Medicine, Flinders Medical Centre,...

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Autores principales:	Mehra S, Ghimire RH, Mingi JJ, Hatch M, Garg H, Adams R, Heraganahally SS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	aboriginal ethnic female gender male obstructive sleep apnoea. Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/31171b931a3344bcb578101c03de2076
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spelling	oai:doaj.org-article:31171b931a3344bcb578101c03de20762021-12-02T10:27:04ZGender Differences in the Clinical and Polysomnographic Characteristics Among Australian Aboriginal Patients with Obstructive Sleep Apnea1179-1608https://doaj.org/article/31171b931a3344bcb578101c03de20762020-08-01T00:00:00Zhttps://www.dovepress.com/gender-differences-in-the-clinical-and-polysomnographic-characteristic-peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608Sumit Mehra,1,2 Ram H Ghimire,1 Joy J Mingi,3,4 Monica Hatch,1 Himanshu Garg,1 Robert Adams,5 Subash S Heraganahally1,3 1Department of Respiratory and Sleep Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia; 2Department of Respiratory and Sleep Medicine, Flinders Medical Centre, Adelaide, South Australia, Australia; 3Darwin Respiratory and Sleep Health, Darwin Private Hospital, Darwin, Northern Territory, Australia; 4Department of Public Health, Charles Darwin University, Darwin, Northern Territory, Australia; 5Adelaide Institute for Sleep Health, a Flinders Centre for Research Excellence, Bedford Park, South Australia, AustraliaCorrespondence: Subash S Heraganahally Email hssubhashcmc@hotmail.comBackground: In this study, we assessed the clinical and polysomnographic (PSG) characteristics according to gender among Australian Aboriginal men and woman diagnosed to have obstructive sleep apnea (OSA).Methods: In this retrospective study, all adult Aboriginal patients over 18 years of age diagnosed to have OSA with an apnea hypopnea index (AHI) > 5/hour over a 5 year period were included.Results: Of the 337 patients (168 females and 169 males), who underwent a diagnostic PSG, 297 (88%) were diagnosed to have OSA (AHI) > 5/hour), 154/297 males (52%) and 143/297 females (48%). Amongst male and female patients with OSA, 63% and 37% were in the severe spectrum (AHI> 30/hour). The male cohort had higher stage N1 NREM sleep (P< 0.001), reduced N3 NREM sleep (P< 0.001), higher AHI severity (P< 0.001), higher NREM AHI (P< 0.001), and high arousal index (P< 0.005). REM sleep-related AHI was higher among female patients with all severity of OSA, along with severe oxygen desaturation during REM sleep. Among patients with severe OSA, the female cohort were younger (age 46 years vs 49 years, P=0.030) and had higher BMI with all severity of OSA, while males had larger neck circumference compared to females. Hypertension increased the odds of severe OSA versus the combined odds of mild and moderate OSA for both genders.Conclusion: This study highlights some important differences in the way sleep apnea manifests in Australian Aboriginal males and females and further studies are warranted to explore avenues to look for a physiological basis for these observations and targeted interventions.Keywords: aboriginal, ethnic, female, gender, male, obstructive sleep apneaMehra SGhimire RHMingi JJHatch MGarg HAdams RHeraganahally SSDove Medical Pressarticleaboriginalethnicfemalegendermaleobstructive sleep apnoea.PsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol Volume 12, Pp 593-602 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	aboriginal ethnic female gender male obstructive sleep apnoea. Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	aboriginal ethnic female gender male obstructive sleep apnoea. Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Mehra S Ghimire RH Mingi JJ Hatch M Garg H Adams R Heraganahally SS Gender Differences in the Clinical and Polysomnographic Characteristics Among Australian Aboriginal Patients with Obstructive Sleep Apnea
description	Sumit Mehra,1,2 Ram H Ghimire,1 Joy J Mingi,3,4 Monica Hatch,1 Himanshu Garg,1 Robert Adams,5 Subash S Heraganahally1,3 1Department of Respiratory and Sleep Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia; 2Department of Respiratory and Sleep Medicine, Flinders Medical Centre, Adelaide, South Australia, Australia; 3Darwin Respiratory and Sleep Health, Darwin Private Hospital, Darwin, Northern Territory, Australia; 4Department of Public Health, Charles Darwin University, Darwin, Northern Territory, Australia; 5Adelaide Institute for Sleep Health, a Flinders Centre for Research Excellence, Bedford Park, South Australia, AustraliaCorrespondence: Subash S Heraganahally Email hssubhashcmc@hotmail.comBackground: In this study, we assessed the clinical and polysomnographic (PSG) characteristics according to gender among Australian Aboriginal men and woman diagnosed to have obstructive sleep apnea (OSA).Methods: In this retrospective study, all adult Aboriginal patients over 18 years of age diagnosed to have OSA with an apnea hypopnea index (AHI) > 5/hour over a 5 year period were included.Results: Of the 337 patients (168 females and 169 males), who underwent a diagnostic PSG, 297 (88%) were diagnosed to have OSA (AHI) > 5/hour), 154/297 males (52%) and 143/297 females (48%). Amongst male and female patients with OSA, 63% and 37% were in the severe spectrum (AHI> 30/hour). The male cohort had higher stage N1 NREM sleep (P< 0.001), reduced N3 NREM sleep (P< 0.001), higher AHI severity (P< 0.001), higher NREM AHI (P< 0.001), and high arousal index (P< 0.005). REM sleep-related AHI was higher among female patients with all severity of OSA, along with severe oxygen desaturation during REM sleep. Among patients with severe OSA, the female cohort were younger (age 46 years vs 49 years, P=0.030) and had higher BMI with all severity of OSA, while males had larger neck circumference compared to females. Hypertension increased the odds of severe OSA versus the combined odds of mild and moderate OSA for both genders.Conclusion: This study highlights some important differences in the way sleep apnea manifests in Australian Aboriginal males and females and further studies are warranted to explore avenues to look for a physiological basis for these observations and targeted interventions.Keywords: aboriginal, ethnic, female, gender, male, obstructive sleep apnea
format	article
author	Mehra S Ghimire RH Mingi JJ Hatch M Garg H Adams R Heraganahally SS
author_facet	Mehra S Ghimire RH Mingi JJ Hatch M Garg H Adams R Heraganahally SS
author_sort	Mehra S
title	Gender Differences in the Clinical and Polysomnographic Characteristics Among Australian Aboriginal Patients with Obstructive Sleep Apnea
title_short	Gender Differences in the Clinical and Polysomnographic Characteristics Among Australian Aboriginal Patients with Obstructive Sleep Apnea
title_full	Gender Differences in the Clinical and Polysomnographic Characteristics Among Australian Aboriginal Patients with Obstructive Sleep Apnea
title_fullStr	Gender Differences in the Clinical and Polysomnographic Characteristics Among Australian Aboriginal Patients with Obstructive Sleep Apnea
title_full_unstemmed	Gender Differences in the Clinical and Polysomnographic Characteristics Among Australian Aboriginal Patients with Obstructive Sleep Apnea
title_sort	gender differences in the clinical and polysomnographic characteristics among australian aboriginal patients with obstructive sleep apnea
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/31171b931a3344bcb578101c03de2076
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Gender Differences in the Clinical and Polysomnographic Characteristics Among Australian Aboriginal Patients with Obstructive Sleep Apnea

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