Hierarchical mechanism of amino acid sensing by the T-box riboswitch

Riboswitches on 5′ ends of mRNAs are important for bacterial gene regulation. Here the authors probe the mechanism of a tRNA aminoacylation sensing T-box riboswitch using single-molecule fluorescence microscopy to characterize dynamic solution conformations and heterogeneous tRNA binding kinetics.

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Autores principales:	Krishna C. Suddala, Javier Cabello-Villegas, Malgorzata Michnicka, Collin Marshall, Edward P. Nikonowicz, Nils G. Walter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/311b4e87aa5d46d280d8e1c2f066cf5b
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spelling	oai:doaj.org-article:311b4e87aa5d46d280d8e1c2f066cf5b2021-12-02T16:49:37ZHierarchical mechanism of amino acid sensing by the T-box riboswitch10.1038/s41467-018-04305-62041-1723https://doaj.org/article/311b4e87aa5d46d280d8e1c2f066cf5b2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04305-6https://doaj.org/toc/2041-1723Riboswitches on 5′ ends of mRNAs are important for bacterial gene regulation. Here the authors probe the mechanism of a tRNA aminoacylation sensing T-box riboswitch using single-molecule fluorescence microscopy to characterize dynamic solution conformations and heterogeneous tRNA binding kinetics.Krishna C. SuddalaJavier Cabello-VillegasMalgorzata MichnickaCollin MarshallEdward P. NikonowiczNils G. WalterNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Krishna C. Suddala Javier Cabello-Villegas Malgorzata Michnicka Collin Marshall Edward P. Nikonowicz Nils G. Walter Hierarchical mechanism of amino acid sensing by the T-box riboswitch
description	Riboswitches on 5′ ends of mRNAs are important for bacterial gene regulation. Here the authors probe the mechanism of a tRNA aminoacylation sensing T-box riboswitch using single-molecule fluorescence microscopy to characterize dynamic solution conformations and heterogeneous tRNA binding kinetics.
format	article
author	Krishna C. Suddala Javier Cabello-Villegas Malgorzata Michnicka Collin Marshall Edward P. Nikonowicz Nils G. Walter
author_facet	Krishna C. Suddala Javier Cabello-Villegas Malgorzata Michnicka Collin Marshall Edward P. Nikonowicz Nils G. Walter
author_sort	Krishna C. Suddala
title	Hierarchical mechanism of amino acid sensing by the T-box riboswitch
title_short	Hierarchical mechanism of amino acid sensing by the T-box riboswitch
title_full	Hierarchical mechanism of amino acid sensing by the T-box riboswitch
title_fullStr	Hierarchical mechanism of amino acid sensing by the T-box riboswitch
title_full_unstemmed	Hierarchical mechanism of amino acid sensing by the T-box riboswitch
title_sort	hierarchical mechanism of amino acid sensing by the t-box riboswitch
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/311b4e87aa5d46d280d8e1c2f066cf5b
work_keys_str_mv	AT krishnacsuddala hierarchicalmechanismofaminoacidsensingbythetboxriboswitch AT javiercabellovillegas hierarchicalmechanismofaminoacidsensingbythetboxriboswitch AT malgorzatamichnicka hierarchicalmechanismofaminoacidsensingbythetboxriboswitch AT collinmarshall hierarchicalmechanismofaminoacidsensingbythetboxriboswitch AT edwardpnikonowicz hierarchicalmechanismofaminoacidsensingbythetboxriboswitch AT nilsgwalter hierarchicalmechanismofaminoacidsensingbythetboxriboswitch
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Hierarchical mechanism of amino acid sensing by the T-box riboswitch

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