Hibernating brown bears are protected against atherogenic dyslipidemia

Abstract To investigate mechanisms by which hibernators avoid atherogenic hyperlipidemia during hibernation, we assessed lipoprotein and cholesterol metabolisms of free-ranging Scandinavian brown bears (Ursus arctos). In winter- and summer-captured bears, we measured lipoprotein sizes and sub-classe...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sylvain Giroud, Isabelle Chery, Mathilde Arrivé, Michel Prost, Julie Zumsteg, Dimitri Heintz, Alina L. Evans, Guillemette Gauquelin-Koch, Jon M. Arnemo, Jon E. Swenson, Etienne Lefai, Fabrice Bertile, Chantal Simon, Stéphane Blanc
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/311dfd1de6d046aa9a6b0b7df863eea9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:311dfd1de6d046aa9a6b0b7df863eea9
record_format	dspace
spelling	oai:doaj.org-article:311dfd1de6d046aa9a6b0b7df863eea92021-12-02T15:15:04ZHibernating brown bears are protected against atherogenic dyslipidemia10.1038/s41598-021-98085-72045-2322https://doaj.org/article/311dfd1de6d046aa9a6b0b7df863eea92021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98085-7https://doaj.org/toc/2045-2322Abstract To investigate mechanisms by which hibernators avoid atherogenic hyperlipidemia during hibernation, we assessed lipoprotein and cholesterol metabolisms of free-ranging Scandinavian brown bears (Ursus arctos). In winter- and summer-captured bears, we measured lipoprotein sizes and sub-classes, triglyceride-related plasma-enzyme activities, and muscle lipid composition along with plasma-levels of antioxidant capacities and inflammatory markers. Although hibernating bears increased nearly all lipid levels, a 36%-higher cholesteryl-ester transfer-protein activity allowed to stabilize lipid composition of high-density lipoproteins (HDL). Levels of inflammatory metabolites, i.e., 7-ketocholesterol and 11ß-prostaglandin F2α, declined in winter and correlated inversely with cardioprotective HDL2b-proportions and HDL-sizes that increased during hibernation. Lower muscle-cholesterol concentrations and lecithin-cholesterol acyltransferase activity in winter suggest that hibernating bears tightly controlled peripheral-cholesterol synthesis and/or release. Finally, greater plasma-antioxidant capacities prevented excessive lipid-specific oxidative damages in plasma and muscles of hibernating bears. Hence, the brown bear manages large lipid fluxes during hibernation, without developing adverse atherogenic effects that occur in humans and non-hibernators.Sylvain GiroudIsabelle CheryMathilde ArrivéMichel ProstJulie ZumstegDimitri HeintzAlina L. EvansGuillemette Gauquelin-KochJon M. ArnemoJon E. SwensonEtienne LefaiFabrice BertileChantal SimonStéphane BlancNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sylvain Giroud Isabelle Chery Mathilde Arrivé Michel Prost Julie Zumsteg Dimitri Heintz Alina L. Evans Guillemette Gauquelin-Koch Jon M. Arnemo Jon E. Swenson Etienne Lefai Fabrice Bertile Chantal Simon Stéphane Blanc Hibernating brown bears are protected against atherogenic dyslipidemia
description	Abstract To investigate mechanisms by which hibernators avoid atherogenic hyperlipidemia during hibernation, we assessed lipoprotein and cholesterol metabolisms of free-ranging Scandinavian brown bears (Ursus arctos). In winter- and summer-captured bears, we measured lipoprotein sizes and sub-classes, triglyceride-related plasma-enzyme activities, and muscle lipid composition along with plasma-levels of antioxidant capacities and inflammatory markers. Although hibernating bears increased nearly all lipid levels, a 36%-higher cholesteryl-ester transfer-protein activity allowed to stabilize lipid composition of high-density lipoproteins (HDL). Levels of inflammatory metabolites, i.e., 7-ketocholesterol and 11ß-prostaglandin F2α, declined in winter and correlated inversely with cardioprotective HDL2b-proportions and HDL-sizes that increased during hibernation. Lower muscle-cholesterol concentrations and lecithin-cholesterol acyltransferase activity in winter suggest that hibernating bears tightly controlled peripheral-cholesterol synthesis and/or release. Finally, greater plasma-antioxidant capacities prevented excessive lipid-specific oxidative damages in plasma and muscles of hibernating bears. Hence, the brown bear manages large lipid fluxes during hibernation, without developing adverse atherogenic effects that occur in humans and non-hibernators.
format	article
author	Sylvain Giroud Isabelle Chery Mathilde Arrivé Michel Prost Julie Zumsteg Dimitri Heintz Alina L. Evans Guillemette Gauquelin-Koch Jon M. Arnemo Jon E. Swenson Etienne Lefai Fabrice Bertile Chantal Simon Stéphane Blanc
author_facet	Sylvain Giroud Isabelle Chery Mathilde Arrivé Michel Prost Julie Zumsteg Dimitri Heintz Alina L. Evans Guillemette Gauquelin-Koch Jon M. Arnemo Jon E. Swenson Etienne Lefai Fabrice Bertile Chantal Simon Stéphane Blanc
author_sort	Sylvain Giroud
title	Hibernating brown bears are protected against atherogenic dyslipidemia
title_short	Hibernating brown bears are protected against atherogenic dyslipidemia
title_full	Hibernating brown bears are protected against atherogenic dyslipidemia
title_fullStr	Hibernating brown bears are protected against atherogenic dyslipidemia
title_full_unstemmed	Hibernating brown bears are protected against atherogenic dyslipidemia
title_sort	hibernating brown bears are protected against atherogenic dyslipidemia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/311dfd1de6d046aa9a6b0b7df863eea9
work_keys_str_mv	AT sylvaingiroud hibernatingbrownbearsareprotectedagainstatherogenicdyslipidemia AT isabellechery hibernatingbrownbearsareprotectedagainstatherogenicdyslipidemia AT mathildearrive hibernatingbrownbearsareprotectedagainstatherogenicdyslipidemia AT michelprost hibernatingbrownbearsareprotectedagainstatherogenicdyslipidemia AT juliezumsteg hibernatingbrownbearsareprotectedagainstatherogenicdyslipidemia AT dimitriheintz hibernatingbrownbearsareprotectedagainstatherogenicdyslipidemia AT alinalevans hibernatingbrownbearsareprotectedagainstatherogenicdyslipidemia AT guillemettegauquelinkoch hibernatingbrownbearsareprotectedagainstatherogenicdyslipidemia AT jonmarnemo hibernatingbrownbearsareprotectedagainstatherogenicdyslipidemia AT joneswenson hibernatingbrownbearsareprotectedagainstatherogenicdyslipidemia AT etiennelefai hibernatingbrownbearsareprotectedagainstatherogenicdyslipidemia AT fabricebertile hibernatingbrownbearsareprotectedagainstatherogenicdyslipidemia AT chantalsimon hibernatingbrownbearsareprotectedagainstatherogenicdyslipidemia AT stephaneblanc hibernatingbrownbearsareprotectedagainstatherogenicdyslipidemia
_version_	1718387559662354432

Hibernating brown bears are protected against atherogenic dyslipidemia

Ejemplares similares