Biomimetic electromechanical stimulation to maintain adult myocardial slices in vitro

Cultured adult cardiac tissue undergoes rapid dedifferentiation, which hinders chronic in vitro studies. Here the authors investigate biomimetic electromechanical stimulation of adult myocardial slices applying different preload conditions, identifying the optimum sarcomere length for prolonged cult...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Samuel A. Watson, James Duff, Ifigeneia Bardi, Magdalena Zabielska, Santosh S. Atanur, Richard J. Jabbour, André Simon, Alejandra Tomas, Ryszard T. Smolenski, Sian E. Harding, Filippo Perbellini, Cesare M. Terracciano
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Q
Acceso en línea:https://doaj.org/article/3121859689094ac79bf739761e7891fe
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Descripción
Sumario:Cultured adult cardiac tissue undergoes rapid dedifferentiation, which hinders chronic in vitro studies. Here the authors investigate biomimetic electromechanical stimulation of adult myocardial slices applying different preload conditions, identifying the optimum sarcomere length for prolonged culturing, and investigating transcriptional profiles associated with functional preservation.