Biomimetic electromechanical stimulation to maintain adult myocardial slices in vitro

Cultured adult cardiac tissue undergoes rapid dedifferentiation, which hinders chronic in vitro studies. Here the authors investigate biomimetic electromechanical stimulation of adult myocardial slices applying different preload conditions, identifying the optimum sarcomere length for prolonged cult...

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Autores principales:	Samuel A. Watson, James Duff, Ifigeneia Bardi, Magdalena Zabielska, Santosh S. Atanur, Richard J. Jabbour, André Simon, Alejandra Tomas, Ryszard T. Smolenski, Sian E. Harding, Filippo Perbellini, Cesare M. Terracciano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3121859689094ac79bf739761e7891fe
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spelling	oai:doaj.org-article:3121859689094ac79bf739761e7891fe2021-12-02T16:57:44ZBiomimetic electromechanical stimulation to maintain adult myocardial slices in vitro10.1038/s41467-019-10175-32041-1723https://doaj.org/article/3121859689094ac79bf739761e7891fe2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10175-3https://doaj.org/toc/2041-1723Cultured adult cardiac tissue undergoes rapid dedifferentiation, which hinders chronic in vitro studies. Here the authors investigate biomimetic electromechanical stimulation of adult myocardial slices applying different preload conditions, identifying the optimum sarcomere length for prolonged culturing, and investigating transcriptional profiles associated with functional preservation.Samuel A. WatsonJames DuffIfigeneia BardiMagdalena ZabielskaSantosh S. AtanurRichard J. JabbourAndré SimonAlejandra TomasRyszard T. SmolenskiSian E. HardingFilippo PerbelliniCesare M. TerraccianoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Samuel A. Watson James Duff Ifigeneia Bardi Magdalena Zabielska Santosh S. Atanur Richard J. Jabbour André Simon Alejandra Tomas Ryszard T. Smolenski Sian E. Harding Filippo Perbellini Cesare M. Terracciano Biomimetic electromechanical stimulation to maintain adult myocardial slices in vitro
description	Cultured adult cardiac tissue undergoes rapid dedifferentiation, which hinders chronic in vitro studies. Here the authors investigate biomimetic electromechanical stimulation of adult myocardial slices applying different preload conditions, identifying the optimum sarcomere length for prolonged culturing, and investigating transcriptional profiles associated with functional preservation.
format	article
author	Samuel A. Watson James Duff Ifigeneia Bardi Magdalena Zabielska Santosh S. Atanur Richard J. Jabbour André Simon Alejandra Tomas Ryszard T. Smolenski Sian E. Harding Filippo Perbellini Cesare M. Terracciano
author_facet	Samuel A. Watson James Duff Ifigeneia Bardi Magdalena Zabielska Santosh S. Atanur Richard J. Jabbour André Simon Alejandra Tomas Ryszard T. Smolenski Sian E. Harding Filippo Perbellini Cesare M. Terracciano
author_sort	Samuel A. Watson
title	Biomimetic electromechanical stimulation to maintain adult myocardial slices in vitro
title_short	Biomimetic electromechanical stimulation to maintain adult myocardial slices in vitro
title_full	Biomimetic electromechanical stimulation to maintain adult myocardial slices in vitro
title_fullStr	Biomimetic electromechanical stimulation to maintain adult myocardial slices in vitro
title_full_unstemmed	Biomimetic electromechanical stimulation to maintain adult myocardial slices in vitro
title_sort	biomimetic electromechanical stimulation to maintain adult myocardial slices in vitro
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3121859689094ac79bf739761e7891fe
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Biomimetic electromechanical stimulation to maintain adult myocardial slices in vitro

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