Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism

SHANK3 mutations have been linked to autism spectrum disorders, although the underlying mechanisms remain unclear. Here, the authors generate a complete knockout Shank3 mouse model, identifying ASD-like behaviours associated with impaired mGluR5-Homer scaffolding and abnormal brain connectivity.

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Autores principales:	Xiaoming Wang, Alexandra L. Bey, Brittany M. Katz, Alexandra Badea, Namsoo Kim, Lisa K. David, Lara J. Duffney, Sunil Kumar, Stephen D. Mague, Samuel W. Hulbert, Nisha Dutta, Volodya Hayrapetyan, Chunxiu Yu, Erin Gaidis, Shengli Zhao, Jin-Dong Ding, Qiong Xu, Leeyup Chung, Ramona M. Rodriguiz, Fan Wang, Richard J. Weinberg, William C. Wetsel, Kafui Dzirasa, Henry Yin, Yong-hui Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/31226ec3e0a84099b658a1cc0d12be11
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spelling	oai:doaj.org-article:31226ec3e0a84099b658a1cc0d12be112021-12-02T15:35:25ZAltered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism10.1038/ncomms114592041-1723https://doaj.org/article/31226ec3e0a84099b658a1cc0d12be112016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11459https://doaj.org/toc/2041-1723SHANK3 mutations have been linked to autism spectrum disorders, although the underlying mechanisms remain unclear. Here, the authors generate a complete knockout Shank3 mouse model, identifying ASD-like behaviours associated with impaired mGluR5-Homer scaffolding and abnormal brain connectivity.Xiaoming WangAlexandra L. BeyBrittany M. KatzAlexandra BadeaNamsoo KimLisa K. DavidLara J. DuffneySunil KumarStephen D. MagueSamuel W. HulbertNisha DuttaVolodya HayrapetyanChunxiu YuErin GaidisShengli ZhaoJin-Dong DingQiong XuLeeyup ChungRamona M. RodriguizFan WangRichard J. WeinbergWilliam C. WetselKafui DzirasaHenry YinYong-hui JiangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-18 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaoming Wang Alexandra L. Bey Brittany M. Katz Alexandra Badea Namsoo Kim Lisa K. David Lara J. Duffney Sunil Kumar Stephen D. Mague Samuel W. Hulbert Nisha Dutta Volodya Hayrapetyan Chunxiu Yu Erin Gaidis Shengli Zhao Jin-Dong Ding Qiong Xu Leeyup Chung Ramona M. Rodriguiz Fan Wang Richard J. Weinberg William C. Wetsel Kafui Dzirasa Henry Yin Yong-hui Jiang Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism
description	SHANK3 mutations have been linked to autism spectrum disorders, although the underlying mechanisms remain unclear. Here, the authors generate a complete knockout Shank3 mouse model, identifying ASD-like behaviours associated with impaired mGluR5-Homer scaffolding and abnormal brain connectivity.
format	article
author	Xiaoming Wang Alexandra L. Bey Brittany M. Katz Alexandra Badea Namsoo Kim Lisa K. David Lara J. Duffney Sunil Kumar Stephen D. Mague Samuel W. Hulbert Nisha Dutta Volodya Hayrapetyan Chunxiu Yu Erin Gaidis Shengli Zhao Jin-Dong Ding Qiong Xu Leeyup Chung Ramona M. Rodriguiz Fan Wang Richard J. Weinberg William C. Wetsel Kafui Dzirasa Henry Yin Yong-hui Jiang
author_facet	Xiaoming Wang Alexandra L. Bey Brittany M. Katz Alexandra Badea Namsoo Kim Lisa K. David Lara J. Duffney Sunil Kumar Stephen D. Mague Samuel W. Hulbert Nisha Dutta Volodya Hayrapetyan Chunxiu Yu Erin Gaidis Shengli Zhao Jin-Dong Ding Qiong Xu Leeyup Chung Ramona M. Rodriguiz Fan Wang Richard J. Weinberg William C. Wetsel Kafui Dzirasa Henry Yin Yong-hui Jiang
author_sort	Xiaoming Wang
title	Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism
title_short	Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism
title_full	Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism
title_fullStr	Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism
title_full_unstemmed	Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism
title_sort	altered mglur5-homer scaffolds and corticostriatal connectivity in a shank3 complete knockout model of autism
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/31226ec3e0a84099b658a1cc0d12be11
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Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism

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