Assessing short-term risk of ischemic stroke in relation to all prescribed medications
Abstract We examined the short-term risk of stroke associated with drugs prescribed in Norway or Sweden in a comprehensive, hypothesis-free manner using comprehensive nation-wide data. We identified 27,680 and 92,561 cases with a first ischemic stroke via the patient- and the cause-of-death register...
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Nature Portfolio
2021
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oai:doaj.org-article:3122b327cdbe4fbe9827a39d51d6da192021-11-08T10:46:47ZAssessing short-term risk of ischemic stroke in relation to all prescribed medications10.1038/s41598-021-01115-72045-2322https://doaj.org/article/3122b327cdbe4fbe9827a39d51d6da192021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01115-7https://doaj.org/toc/2045-2322Abstract We examined the short-term risk of stroke associated with drugs prescribed in Norway or Sweden in a comprehensive, hypothesis-free manner using comprehensive nation-wide data. We identified 27,680 and 92,561 cases with a first ischemic stroke via the patient- and the cause-of-death registers in Norway (2004–2014) and Sweden (2005–2014), respectively, and linked these data to prescription databases. A case-crossover design was used that compares the drugs dispensed within 1 to 14 days before the date of ischemic stroke occurrence with those dispensed 29 to 42 days before the index event. A Bolasso approach, a version of the Lasso regression algorithm, was used to select drugs that acutely either increase or decrease the apparent risk of ischemic stroke. Application of the Bolasso regression algorithm selected 19 drugs which were associated with increased risk for ischemic stroke and 11 drugs with decreased risk in both countries. Morphine in combination with antispasmodics was associated with a particularly high risk of stroke (odds ratio 7.09, 95% confidence intervals 4.81–10.47). Several potentially intriguing associations, both within and across pharmacological classes, merit further investigation in focused, follow-up studies.Imre JanszkyIoannis VardaxisBo Henry LindqvistJens Wilhelm HornBen Michael BrumptonLinn Beate StrandInger Johanne BakkenIngvild Vatten AlsnesPål Richard RomundstadRickard LjungKenneth Jay MukamalAbhijit SenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
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DOAJ |
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Medicine R Science Q |
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Medicine R Science Q Imre Janszky Ioannis Vardaxis Bo Henry Lindqvist Jens Wilhelm Horn Ben Michael Brumpton Linn Beate Strand Inger Johanne Bakken Ingvild Vatten Alsnes Pål Richard Romundstad Rickard Ljung Kenneth Jay Mukamal Abhijit Sen Assessing short-term risk of ischemic stroke in relation to all prescribed medications |
| description |
Abstract We examined the short-term risk of stroke associated with drugs prescribed in Norway or Sweden in a comprehensive, hypothesis-free manner using comprehensive nation-wide data. We identified 27,680 and 92,561 cases with a first ischemic stroke via the patient- and the cause-of-death registers in Norway (2004–2014) and Sweden (2005–2014), respectively, and linked these data to prescription databases. A case-crossover design was used that compares the drugs dispensed within 1 to 14 days before the date of ischemic stroke occurrence with those dispensed 29 to 42 days before the index event. A Bolasso approach, a version of the Lasso regression algorithm, was used to select drugs that acutely either increase or decrease the apparent risk of ischemic stroke. Application of the Bolasso regression algorithm selected 19 drugs which were associated with increased risk for ischemic stroke and 11 drugs with decreased risk in both countries. Morphine in combination with antispasmodics was associated with a particularly high risk of stroke (odds ratio 7.09, 95% confidence intervals 4.81–10.47). Several potentially intriguing associations, both within and across pharmacological classes, merit further investigation in focused, follow-up studies. |
| format |
article |
| author |
Imre Janszky Ioannis Vardaxis Bo Henry Lindqvist Jens Wilhelm Horn Ben Michael Brumpton Linn Beate Strand Inger Johanne Bakken Ingvild Vatten Alsnes Pål Richard Romundstad Rickard Ljung Kenneth Jay Mukamal Abhijit Sen |
| author_facet |
Imre Janszky Ioannis Vardaxis Bo Henry Lindqvist Jens Wilhelm Horn Ben Michael Brumpton Linn Beate Strand Inger Johanne Bakken Ingvild Vatten Alsnes Pål Richard Romundstad Rickard Ljung Kenneth Jay Mukamal Abhijit Sen |
| author_sort |
Imre Janszky |
| title |
Assessing short-term risk of ischemic stroke in relation to all prescribed medications |
| title_short |
Assessing short-term risk of ischemic stroke in relation to all prescribed medications |
| title_full |
Assessing short-term risk of ischemic stroke in relation to all prescribed medications |
| title_fullStr |
Assessing short-term risk of ischemic stroke in relation to all prescribed medications |
| title_full_unstemmed |
Assessing short-term risk of ischemic stroke in relation to all prescribed medications |
| title_sort |
assessing short-term risk of ischemic stroke in relation to all prescribed medications |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/3122b327cdbe4fbe9827a39d51d6da19 |
| work_keys_str_mv |
AT imrejanszky assessingshorttermriskofischemicstrokeinrelationtoallprescribedmedications AT ioannisvardaxis assessingshorttermriskofischemicstrokeinrelationtoallprescribedmedications AT bohenrylindqvist assessingshorttermriskofischemicstrokeinrelationtoallprescribedmedications AT jenswilhelmhorn assessingshorttermriskofischemicstrokeinrelationtoallprescribedmedications AT benmichaelbrumpton assessingshorttermriskofischemicstrokeinrelationtoallprescribedmedications AT linnbeatestrand assessingshorttermriskofischemicstrokeinrelationtoallprescribedmedications AT ingerjohannebakken assessingshorttermriskofischemicstrokeinrelationtoallprescribedmedications AT ingvildvattenalsnes assessingshorttermriskofischemicstrokeinrelationtoallprescribedmedications AT palrichardromundstad assessingshorttermriskofischemicstrokeinrelationtoallprescribedmedications AT rickardljung assessingshorttermriskofischemicstrokeinrelationtoallprescribedmedications AT kennethjaymukamal assessingshorttermriskofischemicstrokeinrelationtoallprescribedmedications AT abhijitsen assessingshorttermriskofischemicstrokeinrelationtoallprescribedmedications |
| _version_ |
1718442605504626688 |