Engineered osteoclasts as living treatment materials for heterotopic ossification therapy

Heterotopic ossification (HO) is the formation of pathological mature bone within extraskeletal soft tissues, and there are currently no reliable methods for removing these calcified plaques. Here, the authors demonstrate that chemically engineered osteoclasts coated with tetracycline can improve th...

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Autores principales:	Wenjing Jin, Xianfeng Lin, Haihua Pan, Chenchen Zhao, Pengcheng Qiu, Ruibo Zhao, Zihe Hu, Yanyan Zhou, Haiyan Wu, Xiao Chen, Hongwei Ouyang, Zhijian Xie, Ruikang Tang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/312539649fa2407bb7806c12f6527e7d
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spelling	oai:doaj.org-article:312539649fa2407bb7806c12f6527e7d2021-11-08T11:08:58ZEngineered osteoclasts as living treatment materials for heterotopic ossification therapy10.1038/s41467-021-26593-12041-1723https://doaj.org/article/312539649fa2407bb7806c12f6527e7d2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26593-1https://doaj.org/toc/2041-1723Heterotopic ossification (HO) is the formation of pathological mature bone within extraskeletal soft tissues, and there are currently no reliable methods for removing these calcified plaques. Here, the authors demonstrate that chemically engineered osteoclasts coated with tetracycline can improve their targeting capacity to ectopic calcifications, which extends their bone resorption functions for the treatment of HO.Wenjing JinXianfeng LinHaihua PanChenchen ZhaoPengcheng QiuRuibo ZhaoZihe HuYanyan ZhouHaiyan WuXiao ChenHongwei OuyangZhijian XieRuikang TangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenjing Jin Xianfeng Lin Haihua Pan Chenchen Zhao Pengcheng Qiu Ruibo Zhao Zihe Hu Yanyan Zhou Haiyan Wu Xiao Chen Hongwei Ouyang Zhijian Xie Ruikang Tang Engineered osteoclasts as living treatment materials for heterotopic ossification therapy
description	Heterotopic ossification (HO) is the formation of pathological mature bone within extraskeletal soft tissues, and there are currently no reliable methods for removing these calcified plaques. Here, the authors demonstrate that chemically engineered osteoclasts coated with tetracycline can improve their targeting capacity to ectopic calcifications, which extends their bone resorption functions for the treatment of HO.
format	article
author	Wenjing Jin Xianfeng Lin Haihua Pan Chenchen Zhao Pengcheng Qiu Ruibo Zhao Zihe Hu Yanyan Zhou Haiyan Wu Xiao Chen Hongwei Ouyang Zhijian Xie Ruikang Tang
author_facet	Wenjing Jin Xianfeng Lin Haihua Pan Chenchen Zhao Pengcheng Qiu Ruibo Zhao Zihe Hu Yanyan Zhou Haiyan Wu Xiao Chen Hongwei Ouyang Zhijian Xie Ruikang Tang
author_sort	Wenjing Jin
title	Engineered osteoclasts as living treatment materials for heterotopic ossification therapy
title_short	Engineered osteoclasts as living treatment materials for heterotopic ossification therapy
title_full	Engineered osteoclasts as living treatment materials for heterotopic ossification therapy
title_fullStr	Engineered osteoclasts as living treatment materials for heterotopic ossification therapy
title_full_unstemmed	Engineered osteoclasts as living treatment materials for heterotopic ossification therapy
title_sort	engineered osteoclasts as living treatment materials for heterotopic ossification therapy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/312539649fa2407bb7806c12f6527e7d
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Engineered osteoclasts as living treatment materials for heterotopic ossification therapy

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